1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	H	G	R	G	R	Y	R	P	L	V	R	C	V	R	P	R	R	V	A	A	S	V	R	T	P	I	A	C	L	A	A	V	V	V	I	A	G	C	T	T	V	V	D	G	R	A	L	S	I	L	N	D	P	F	R	V	G	G	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?										?	?	?	?	?	?	?	?	?	?														?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	A	T	N	G	P	S	G	A	R	P	D	A	P	A	A	S	G	T	V	I	N	T	N	N	G	A	I	D	K	L	S	L	L	S	V	N	D	I	E	D	Y	W	M	A	V	Y	S	E	S	L	K	G	T	F	R	P	V	G	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	V	S	Y	D	S	N	D	P	S	S	P	I	V	C	H	I	D	T	Y	Q	L	V	N	A	F	F	S	S	R	C	N	L	I	A	W	D	R	G	V	F	M	A	V	A	Q	E	Y	F	G	D	M	S	V	N	G	V	L	A	H
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?																										?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	F	G	H	A	L	Q	V	M	A	N	L	V	T	R	K	D	P	T	I	V	R	E	Q	Q	A	D	C	F	A	G	V	Y	L	W	W	V	A	E	G	K	S	T	R	F	T	L	S	T	A	D	G	L	D	H	V	L	A	G	I
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?																								?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	T	T	R	D	P	V	M	E	A	D	A	E	N	D	D	E	H	G	S	A	L	D	R	V	S	A	F	Q	L	G	F	I	N	G	T	P	A	C	A	A	I	D	E	D	E	V	E	R	R	R	G	D	L	P	T	A	L	R	V
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?	?																					?					?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		D	A	S	G	N	P	E	T	G	E	V	G	I	N	E	E	T	L	S	T	L	M	E	L	M	G	K	I	F	S	P	K	N	P	P	T	L	S	Y	Q	P	A	G	C	P	D	A	K	P	S	P	P	A	A	Y	C	P	A	T	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?																								?			?	?	?		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		T	I	V	V	D	L	P	A	L	A	R	M	G	K	V	A	S	A	A	E	H	S	L	P	Q	G	D	D	T	S	L	S	I	V	M	S	R	Y	A	L	A	V	Q	H	E	R	G	L	P	M	Q	S	P	W	T	A	L	R	T	A
Secondary structure
SS confidence
Disorder													?		?	?	?	?	?	?	?	?	?	?		?																					?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		C	L	T	G	V	A	H	R	K	M	A	V	P	I	D	L	P	S	G	Q	Q	L	V	L	T	A	G	D	L	D	E	A	V	S	G	L	L	T	N	R	M	V	A	S	D	A	D	G	V	S	V	P	A	G	F	T	R	I	A	A
Secondary structure
SS confidence
Disorder													?		?	?	?	?	?	?	?		?	?	?	?													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.
Sequence		F	R	A	G	V	G	G	D	M	D	A	C	Y	A	R	Y	P	G
Secondary structure
SS confidence
Disorder															?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 40%) Alpha helix ( 47%) Beta strand ( 4%) TM helix ( 3%) (View membrane topology prediction)

Rank Aligned region

PDB 3c37 chain B Region: 99 - 270 Aligned: 128 Modelled: 157 Confidence: 98.2% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:peptidase, m48 family; PDBTitle: x-ray structure of the putative zn-dependent peptidase q74d82 at the2 resolution 1.7 a. northeast structural genomics consortium target3 gsr143a Phyre2 PDB 4aw6 chain B Region: 136 - 270 Aligned: 114 Modelled: 121 Confidence: 97.6% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:caax prenyl protease 1 homolog; PDBTitle: crystal structure of the human nuclear membrane zinc metalloprotease2 zmpste24 (face1) Phyre2 PDB 4il3 chain B Region: 136 - 267 Aligned: 111 Modelled: 118 Confidence: 97.5% Identity: 26% PDB header:hydrolase Chain: B: PDB Molecule:ste24p; PDBTitle: crystal structure of s. mikatae ste24p Phyre2 PDB 6ait chain D Region: 99 - 217 Aligned: 98 Modelled: 104 Confidence: 97.0% Identity: 22% PDB header:hydrolase Chain: D: PDB Molecule:beta-barrel assembly-enhancing protease; PDBTitle: crystal structure of e. coli bepa Phyre2 PDB 3dtk chain A Region: 174 - 239 Aligned: 53 Modelled: 66 Confidence: 96.4% Identity: 28% PDB header:gene regulation Chain: A: PDB Molecule:irre protein; PDBTitle: crystal structure of the irre protein, a central regulator2 of dna damage repair in deinococcaceae Phyre2 PDB 2vqx chain A Region: 177 - 233 Aligned: 57 Modelled: 57 Confidence: 96.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:metalloproteinase; PDBTitle: precursor of protealysin, metalloproteinase from serratia2 proteamaculans. Phyre2 PDB 1kjp chain A Region: 177 - 222 Aligned: 46 Modelled: 46 Confidence: 95.3% Identity: 20% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Thermolysin-like Phyre2 PDB 1bqb chain A Region: 177 - 210 Aligned: 34 Modelled: 34 Confidence: 94.9% Identity: 35% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Thermolysin-like Phyre2 PDB 1npc chain A Region: 177 - 222 Aligned: 46 Modelled: 46 Confidence: 94.9% Identity: 17% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Thermolysin-like Phyre2 PDB 4ger chain B Region: 177 - 210 Aligned: 34 Modelled: 34 Confidence: 94.4% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:gentlyase metalloprotease; PDBTitle: crystal structure of gentlyase, the neutral metalloprotease of2 paenibacillus polymyxa Phyre2 PDB 4k90 chain A Region: 177 - 229 Aligned: 53 Modelled: 53 Confidence: 94.2% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:extracellular metalloproteinase mep; PDBTitle: extracellular metalloproteinase from aspergillus Phyre2 PDB 3cqb chain B Region: 139 - 184 Aligned: 41 Modelled: 46 Confidence: 93.6% Identity: 29% PDB header:hydrolase Chain: B: PDB Molecule:probable protease htpx homolog; PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633 Phyre2 PDB 3nqz chain B Region: 177 - 222 Aligned: 46 Modelled: 46 Confidence: 93.5% Identity: 13% PDB header:hydrolase Chain: B: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of the autoprocessed vibriolysin mcp-02 with e369a2 mutation Phyre2 PDB 3nqx chain A Region: 177 - 222 Aligned: 46 Modelled: 46 Confidence: 92.9% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:secreted metalloprotease mcp02; PDBTitle: crystal structure of vibriolysin mcp-02 mature enzyme, a zinc2 metalloprotease from m4 family Phyre2 PDB 3sks chain A Region: 170 - 190 Aligned: 21 Modelled: 21 Confidence: 92.9% Identity: 48% PDB header:hydrolase Chain: A: PDB Molecule:putative oligoendopeptidase f; PDBTitle: crystal structure of a putative oligoendopeptidase f from bacillus2 anthracis str. ames Phyre2 PDB 5l43 chain B Region: 170 - 199 Aligned: 30 Modelled: 30 Confidence: 91.6% Identity: 27% PDB header:hydrolase Chain: B: PDB Molecule:k-26 dipeptidyl carboxypeptidase; PDBTitle: structure of k26-dcp Phyre2 PDB 3ce2 chain A Region: 170 - 190 Aligned: 21 Modelled: 21 Confidence: 91.4% Identity: 33% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative peptidase; PDBTitle: crystal structure of putative peptidase from chlamydophila abortus Phyre2 PDB 1y79 chain 1 Region: 170 - 199 Aligned: 30 Modelled: 30 Confidence: 91.1% Identity: 23% PDB header:hydrolase Chain: 1: PDB Molecule:peptidyl-dipeptidase dcp; PDBTitle: crystal structure of the e.coli dipeptidyl carboxypeptidase2 dcp in complex with a peptidic inhibitor Phyre2 PDB 2h1j chain A Region: 170 - 190 Aligned: 21 Modelled: 21 Confidence: 91.1% Identity: 48% PDB header:hydrolase Chain: A: PDB Molecule:oligoendopeptidase f; PDBTitle: 3.1 a x-ray structure of putative oligoendopeptidase f: crystals grown2 by microfluidic seeding Phyre2 PDB 1s4b chain P Region: 170 - 199 Aligned: 30 Modelled: 30 Confidence: 91.0% Identity: 17% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Neurolysin-like Phyre2 1 c3c37B_ 2 c4aw6B_ 3 c4il3B_ 4 c6aitD_ 5 c3dtkA_ 6 c2vqxA_ 7 d1kjpa_ 8 d1bqba_ 9 d1npca_ 10 c4gerB_ 11 c4k90A_ 12 c3cqbB_ 13 c3nqzB_ 14 c3nqxA_ 15 c3sksA_ 16 c5l43B_ 17 c3ce2A_ 18 c1y791_ 19 c2h1jA_ 20 d1s4bp_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156