1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	R	L	H	D	A	S	A	A	A	P	E	S	R	M	H	I	A	R	H	G	E	A	V	N	R	R	Q	M	F	I	G	I	T	G	L	L	L	A	V	I	G	L	M	A	L	W	F	P	V	Y	L	D	Q	Y	D	A	Y	G	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	V	T	C	G	S	G	W	R	S	N	L	T	Q	A	L	Y	A	D	G	N	D	N	T	Q	A	L	V	T	R	C	D	T	A	L	L	V	R	R	A	W	A	I	P	S	V	A	L	G	W	L	L	V	T	G	F	L	V	M	W
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.
Sequence		V	H	N	D	Q	H	Q	G	Q	S	Y	P	G	Y	R	A
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 25%) Alpha helix ( 73%) Beta strand ( 0%) TM helix ( 35%) (View membrane topology prediction)

Rank Aligned region

PDB 5t42 chain A Region: 27 - 51 Aligned: 25 Modelled: 25 Confidence: 58.0% Identity: 48% PDB header:viral protein Chain: A: PDB Molecule:envelope glycoprotein; PDBTitle: structure of the ebola virus envelope protein mper/tm domain and its2 interaction with the fusion loop explains their fusion activity Phyre2 PDB 2lom chain A Region: 104 - 130 Aligned: 27 Modelled: 27 Confidence: 25.5% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:hig1 domain family member 1a; PDBTitle: backbone structure of human membrane protein higd1a Phyre2 PDB 5xnm chain J Region: 29 - 48 Aligned: 19 Modelled: 20 Confidence: 25.2% Identity: 47% PDB header:membrane protein Chain: J: PDB Molecule:photosystem ii reaction center protein j; PDBTitle: structure of unstacked c2s2m2-type psii-lhcii supercomplex from pisum2 sativum Phyre2 PDB 3jcu chain J Region: 29 - 48 Aligned: 19 Modelled: 20 Confidence: 19.4% Identity: 42% PDB header:membrane protein Chain: J: PDB Molecule:photosystem ii reaction center protein j; PDBTitle: cryo-em structure of spinach psii-lhcii supercomplex at 3.2 angstrom2 resolution Phyre2 PDB 1p84 chain E Region: 11 - 50 Aligned: 40 Modelled: 40 Confidence: 16.6% Identity: 18% PDB header:oxidoreductase Chain: E: PDB Molecule:ubiquinol-cytochrome c reductase iron-sulfur subunit; PDBTitle: hdbt inhibited yeast cytochrome bc1 complex Phyre2 PDB 6dln chain B Region: 29 - 52 Aligned: 22 Modelled: 22 Confidence: 16.5% Identity: 23% PDB header:membrane protein Chain: B: PDB Molecule:transmembrane protein gp41; PDBTitle: oligomeric structure of the hiv gp41 mper-tmd in phospholipid bilayers Phyre2 PDB 5ydf chain A Region: 79 - 94 Aligned: 16 Modelled: 16 Confidence: 13.6% Identity: 19% PDB header:transcription Chain: A: PDB Molecule:parafibromin; PDBTitle: crystal structure of a disease-related gene, hcdc73(1-100) Phyre2 PDB 4gd3 chain T Region: 15 - 47 Aligned: 33 Modelled: 33 Confidence: 12.9% Identity: 18% PDB header:oxidoreductase/electron transport Chain: T: PDB Molecule:hydrogenase-1 small chain; PDBTitle: structure of e. coli hydrogenase-1 in complex with cytochrome b Phyre2 PDB 1u2c chain A domain 2 Region: 60 - 66 Aligned: 7 Modelled: 7 Confidence: 11.1% Identity: 29% Fold: Dystroglycan, domain 2 Superfamily: Dystroglycan, domain 2 Family: Dystroglycan, domain 2 Phyre2 PDB 5kk2 chain E Region: 26 - 61 Aligned: 35 Modelled: 36 Confidence: 10.8% Identity: 23% PDB header:membrane protein, transport protein, sig Chain: E: PDB Molecule:voltage-dependent calcium channel gamma-2 subunit; PDBTitle: architecture of fully occupied glua2 ampa receptor - tarp complex2 elucidated by single particle cryo-electron microscopy Phyre2 PDB 2lon chain A Region: 96 - 130 Aligned: 35 Modelled: 35 Confidence: 10.6% Identity: 17% PDB header:membrane protein Chain: A: PDB Molecule:hig1 domain family member 1b; PDBTitle: backbone structure of human membrane protein higd1b Phyre2 PDB 2k9y chain A Region: 105 - 119 Aligned: 15 Modelled: 15 Confidence: 10.1% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:ephrin type-a receptor 2; PDBTitle: epha2 dimeric structure in the lipidic bicelle at ph 5.0 Phyre2 PDB 2k9y chain B Region: 105 - 119 Aligned: 15 Modelled: 15 Confidence: 10.1% Identity: 20% PDB header:transferase Chain: B: PDB Molecule:ephrin type-a receptor 2; PDBTitle: epha2 dimeric structure in the lipidic bicelle at ph 5.0 Phyre2 PDB 1r18 chain A Region: 60 - 72 Aligned: 13 Modelled: 13 Confidence: 9.7% Identity: 31% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Protein-L-isoaspartyl O-methyltransferase Phyre2 PDB 1fvi chain A domain 1 Region: 59 - 72 Aligned: 14 Modelled: 14 Confidence: 9.1% Identity: 21% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: DNA ligase/mRNA capping enzyme postcatalytic domain Phyre2 PDB 2mi2 chain A Region: 29 - 48 Aligned: 19 Modelled: 20 Confidence: 9.0% Identity: 26% PDB header:transport protein Chain: A: PDB Molecule:sec-independent protein translocase protein tatb; PDBTitle: solution structure of the e. coli tatb protein in dpc micelles Phyre2 PDB 3jcu chain W Region: 107 - 121 Aligned: 15 Modelled: 15 Confidence: 8.4% Identity: 40% PDB header:membrane protein Chain: W: PDB Molecule:photosystem ii reaction center w protein, chloroplastic; PDBTitle: cryo-em structure of spinach psii-lhcii supercomplex at 3.2 angstrom2 resolution Phyre2 PDB 6q56 chain C Region: 60 - 70 Aligned: 11 Modelled: 11 Confidence: 7.8% Identity: 0% PDB header:rna binding protein Chain: C: PDB Molecule:trna (adenine(22)-n(1))-methyltransferase; PDBTitle: crystal structure of the b. subtilis m1a22 trna methyltransferase trmk Phyre2 PDB 3jbr chain E Region: 37 - 65 Aligned: 28 Modelled: 29 Confidence: 7.7% Identity: 18% PDB header:membrane protein Chain: E: PDB Molecule:voltage-dependent calcium channel gamma-1 subunit; PDBTitle: cryo-em structure of the rabbit voltage-gated calcium channel cav1.12 complex at 4.2 angstrom Phyre2 PDB 6ith chain A Region: 36 - 52 Aligned: 17 Modelled: 17 Confidence: 7.7% Identity: 18% PDB header:membrane protein Chain: A: PDB Molecule:syndecan-2; PDBTitle: structure of the transmembrane domain of syndecan 2 in micelles Phyre2 1 c5t42A_ 2 c2lomA_ 3 c5xnmj_ 4 c3jcuj_ 5 c1p84E_ 6 c6dlnB_ 7 c5ydfA_ 8 c4gd3T_ 9 d1u2ca2 10 c5kk2E_ 11 c2lonA_ 12 c2k9yA_ 13 c2k9yB_ 14 d1r18a_ 15 d1fvia1 16 c2mi2A_ 17 c3jcuw_ 18 c6q56C_ 19 c3jbrE_ 20 c6ithA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41