1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	K	T	I	A	Y	D	E	E	A	R	R	G	L	E	R	G	L	N	A	L	A	D	A	V	K	V	T	L	G	P	K	G	R	N	V	V	L	E	K	K	W	G	A	P	T	I	T	N	D	G	V	S	I	A	K	E	I	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	E	D	P	Y	E	K	I	G	A	E	L	V	K	E	V	A	K	K	T	D	D	V	A	G	D	G	T	T	T	A	T	V	L	A	Q	A	L	V	R	E	G	L	R	N	V	A	A	G	A	N	P	L	G	L	K	R	G	I	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		K	A	V	E	K	V	T	E	T	L	L	K	G	A	K	E	V	E	T	K	E	Q	I	A	A	T	A	A	I	S	A	G	D	Q	S	I	G	D	L	I	A	E	A	M	D	K	V	G	N	E	G	V	I	T	V	E	E	S	N	T
Secondary structure
SS confidence
Disorder															?																?	?	?																											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	G	L	Q	L	E	L	T	E	G	M	R	F	D	K	G	Y	I	S	G	Y	F	V	T	D	P	E	R	Q	E	A	V	L	E	D	P	Y	I	L	L	V	S	S	K	V	S	T	V	K	D	L	L	P	L	L	E	K	V	I	G
Secondary structure
SS confidence
Disorder		?	?																	?					?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	G	K	P	L	L	I	I	A	E	D	V	E	G	E	A	L	S	T	L	V	V	N	K	I	R	G	T	F	K	S	V	A	V	K	A	P	G	F	G	D	R	R	K	A	M	L	Q	D	M	A	I	L	T	G	G	Q	V	I	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		E	E	V	G	L	T	L	E	N	A	D	L	S	L	L	G	K	A	R	K	V	V	V	T	K	D	E	T	T	I	V	E	G	A	G	D	T	D	A	I	A	G	R	V	A	Q	I	R	Q	E	I	E	N	S	D	S	D	Y	D	R
Secondary structure
SS confidence
Disorder		?		?	?																																																	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		E	K	L	Q	E	R	L	A	K	L	A	G	G	V	A	V	I	K	A	G	A	A	T	E	V	E	L	K	E	R	K	H	R	I	E	D	A	V	R	N	A	K	A	A	V	E	E	G	I	V	A	G	G	G	V	T	L	L	Q	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		A	P	T	L	D	E	L	K	L	E	G	D	E	A	T	G	A	N	I	V	K	V	A	L	E	A	P	L	K	Q	I	A	F	N	S	G	L	E	P	G	V	V	A	E	K	V	R	N	L	P	A	G	H	G	L	N	A	Q	T	G
Secondary structure
SS confidence
Disorder								?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		V	Y	E	D	L	L	A	A	G	V	A	D	P	V	K	V	T	R	S	A	L	Q	N	A	A	S	I	A	G	L	F	L	T	T	E	A	V	V	A	D	K	P	E	K	E	K	A	S	V	P	G	G	G	D	M	G	G	M	D	F
Secondary structure
SS confidence
Disorder																																								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
Sequence
Secondary structure
SS confidence
Disorder
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 55%) Beta strand ( 12%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 5cdi chain B Region: 5 - 523 Aligned: 519 Modelled: 519 Confidence: 100.0% Identity: 51% PDB header:chaperone Chain: B: PDB Molecule:chaperonin 60b1; PDBTitle: chloroplast chaperonin 60b1 of chlamydomonas Phyre2 PDB 1kp8 chain B Region: 2 - 523 Aligned: 522 Modelled: 522 Confidence: 100.0% Identity: 60% PDB header:chaperone Chain: B: PDB Molecule:groel protein; PDBTitle: structural basis for groel-assisted protein folding from the crystal2 structure of (groel-kmgatp)14 at 2.0 a resolution Phyre2 PDB 1we3 chain D Region: 2 - 523 Aligned: 522 Modelled: 522 Confidence: 100.0% Identity: 66% PDB header:chaperone Chain: D: PDB Molecule:cpn60(groel); PDBTitle: crystal structure of the chaperonin complex cpn60/cpn10/(adp)7 from2 thermus thermophilus Phyre2 PDB 4pj1 chain E Region: 2 - 522 Aligned: 521 Modelled: 521 Confidence: 100.0% Identity: 47% PDB header:chaperone Chain: E: PDB Molecule:60 kda heat shock protein, mitochondrial; PDBTitle: crystal structure of the human mitochondrial chaperonin symmetrical2 'football' complex Phyre2 PDB 5da8 chain N Region: 2 - 522 Aligned: 507 Modelled: 518 Confidence: 100.0% Identity: 56% PDB header:chaperone Chain: N: PDB Molecule:60 kda chaperonin; PDBTitle: crystal structure of chaperonin groel from Phyre2 PDB 1iok chain E Region: 2 - 522 Aligned: 474 Modelled: 478 Confidence: 100.0% Identity: 59% PDB header:chaperone Chain: E: PDB Molecule:chaperonin 60; PDBTitle: crystal structure of chaperonin-60 from paracoccus2 denitrificans Phyre2 PDB 3p9e chain I Region: 7 - 529 Aligned: 501 Modelled: 501 Confidence: 100.0% Identity: 19% PDB header:chaperone Chain: I: PDB Molecule: PDBTitle: the crystal structure of yeast cct reveals intrinsic asymmetry of2 eukaryotic cytosolic chaperonins Phyre2 PDB 3iyg chain G Region: 7 - 522 Aligned: 489 Modelled: 496 Confidence: 100.0% Identity: 19% PDB header:chaperone Chain: G: PDB Molecule:t-complex protein 1 subunit gamma; PDBTitle: ca model of bovine tric/cct derived from a 4.0 angstrom cryo-em map Phyre2 PDB 3iyg chain E Region: 7 - 520 Aligned: 488 Modelled: 495 Confidence: 100.0% Identity: 20% PDB header:chaperone Chain: E: PDB Molecule:t-complex protein 1 subunit; PDBTitle: ca model of bovine tric/cct derived from a 4.0 angstrom cryo-em map Phyre2 PDB 3iyg chain A Region: 8 - 522 Aligned: 493 Modelled: 503 Confidence: 100.0% Identity: 19% PDB header:chaperone Chain: A: PDB Molecule:t-complex protein 1 subunit alpha; PDBTitle: ca model of bovine tric/cct derived from a 4.0 angstrom cryo-em map Phyre2 PDB 3p9e chain N Region: 7 - 528 Aligned: 493 Modelled: 501 Confidence: 100.0% Identity: 19% PDB header:chaperone Chain: N: PDB Molecule: PDBTitle: the crystal structure of yeast cct reveals intrinsic asymmetry of2 eukaryotic cytosolic chaperonins Phyre2 PDB 3iyg chain D Region: 8 - 521 Aligned: 488 Modelled: 492 Confidence: 100.0% Identity: 23% PDB header:chaperone Chain: D: PDB Molecule:t-complex protein 1 subunit delta; PDBTitle: ca model of bovine tric/cct derived from a 4.0 angstrom cryo-em map Phyre2 PDB 4b2t chain E Region: 3 - 520 Aligned: 463 Modelled: 479 Confidence: 100.0% Identity: 21% PDB header:chaperone Chain: E: PDB Molecule:t-complex protein 1 subunit epsilon; PDBTitle: the crystal structures of the eukaryotic chaperonin cct2 reveal its functional partitioning Phyre2 PDB 4b2t chain Q Region: 2 - 521 Aligned: 459 Modelled: 469 Confidence: 100.0% Identity: 21% PDB header:chaperone Chain: Q: PDB Molecule:t-complex protein 1 subunit theta; PDBTitle: the crystal structures of the eukaryotic chaperonin cct2 reveal its functional partitioning Phyre2 PDB 3p9d chain L Region: 2 - 521 Aligned: 495 Modelled: 508 Confidence: 100.0% Identity: 21% PDB header:chaperone Chain: L: PDB Molecule:t-complex protein 1 subunit delta; PDBTitle: the crystal structure of yeast cct reveals intrinsic asymmetry of2 eukaryotic cytosolic chaperonins Phyre2 PDB 4b2t chain D Region: 7 - 521 Aligned: 460 Modelled: 464 Confidence: 100.0% Identity: 25% PDB header:chaperone Chain: D: PDB Molecule:t-complex protein 1 subunit delta; PDBTitle: the crystal structures of the eukaryotic chaperonin cct2 reveal its functional partitioning Phyre2 PDB 1q2v chain A Region: 3 - 522 Aligned: 491 Modelled: 499 Confidence: 100.0% Identity: 26% PDB header:chaperone Chain: A: PDB Molecule:thermosome alpha subunit; PDBTitle: crystal structure of the chaperonin from thermococcus strain ks-12 (nucleotide-free form) Phyre2 PDB 3los chain C Region: 7 - 537 Aligned: 496 Modelled: 519 Confidence: 100.0% Identity: 27% PDB header:chaperone Chain: C: PDB Molecule:chaperonin; PDBTitle: atomic model of mm-cpn in the closed state Phyre2 PDB 3iyg chain Z Region: 5 - 520 Aligned: 488 Modelled: 495 Confidence: 100.0% Identity: 21% PDB header:chaperone Chain: Z: PDB Molecule:t-complex protein 1 subunit zeta; PDBTitle: ca model of bovine tric/cct derived from a 4.0 angstrom cryo-em map Phyre2 PDB 3p9e chain O Region: 7 - 524 Aligned: 488 Modelled: 497 Confidence: 100.0% Identity: 20% PDB header:chaperone Chain: O: PDB Molecule: PDBTitle: the crystal structure of yeast cct reveals intrinsic asymmetry of2 eukaryotic cytosolic chaperonins Phyre2 1 c5cdiB_ 2 c1kp8B_ 3 c1we3D_ 4 c4pj1E_ 5 c5da8N_ 6 c1iokE_ 7 c3p9ei_ 8 c3iygG_ 9 c3iygE_ 10 c3iygA_ 11 c3p9en_ 12 c3iygD_ 13 c4b2tE_ 14 c4b2tQ_ 15 c3p9dL_ 16 c4b2tD_ 17 c1q2vA_ 18 c3losC_ 19 c3iygZ_ 20 c3p9eo_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99