1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	V	T	S	V	S	A	L	A	V	A	V	V	H	S	V	A	F	A	I	G	R	R	I	G	R	Y	N	V	V	D	V	V	W	G	L	G	F	V	A	V	A	V	A	A	A	T	L	G	H	G	D	P	V	R	R	W	L	L	L
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	L	V	S	T	W	G	L	R	L	S	W	H	M	Y	R	K	T	A	G	Q	G	E	D	P	R	Y	A	D	L	L	R	G	A	T	P	V	Q	A	L	R	K	V	F	G	L	Q	G	L	L	T	L	F	V	S	F	P	L	Q	L
Secondary structure
SS confidence
Disorder																							?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	A	V	T	G	P	T	P	K	P	L	L	A	V	G	G	V	G	L	A	V	W	L	V	G	I	T	F	E	A	V	G	D	W	Q	L	W	V	F	K	S	D	P	A	N	R	G	V	I	M	D	R	G	L	W	A	W	T	R	H
Secondary structure
SS confidence
Disorder																																									?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	N	Y	F	G	D	A	C	V	W	W	G	L	W	L	I	T	I	N	D	W	A	P	L	A	T	V	G	S	P	L	L	M	T	Y	L	L	V	D	V	S	G	A	R	L	T	E	R	Y	L	K	G	R	P	G	F	A	E	Y	Q
Secondary structure
SS confidence
Disorder																																											?									?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.
Sequence		R	R	T	A	Y	F	V	P	R	P	P	R	S	A	R	R
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 71%) Beta strand ( 1%) TM helix ( 53%) (View membrane topology prediction)

Rank Aligned region

PDB 4a2n chain B Region: 53 - 249 Aligned: 184 Modelled: 197 Confidence: 99.9% Identity: 12% PDB header:transferase Chain: B: PDB Molecule:isoprenylcysteine carboxyl methyltransferase; PDBTitle: crystal structure of ma-icmt Phyre2 PDB 4quv chain B Region: 33 - 250 Aligned: 202 Modelled: 218 Confidence: 99.9% Identity: 17% PDB header:oxidoreductase, membrane protein Chain: B: PDB Molecule:delta(14)-sterol reductase; PDBTitle: structure of an integral membrane delta(14)-sterol reductase Phyre2 PDB 5v7p chain A Region: 6 - 251 Aligned: 232 Modelled: 246 Confidence: 99.9% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:protein-s-isoprenylcysteine o-methyltransferase; PDBTitle: atomic structure of the eukaryotic intramembrane ras methyltransferase2 icmt (isoprenylcysteine carboxyl methyltransferase), in complex with3 a monobody Phyre2 PDB 4y9i chain A Region: 221 - 248 Aligned: 28 Modelled: 28 Confidence: 72.1% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:mycobacterium tuberculosis paralogous family 11; PDBTitle: structure of f420-h2 dependent reductase (fdr-a) msmeg_2027 Phyre2 PDB 3r5y chain C Region: 221 - 248 Aligned: 28 Modelled: 28 Confidence: 68.0% Identity: 32% PDB header:unknown function Chain: C: PDB Molecule:putative uncharacterized protein; PDBTitle: structure of a deazaflavin-dependent nitroreductase from nocardia2 farcinica, with co-factor f420 Phyre2 PDB 3r5w chain O Region: 221 - 248 Aligned: 28 Modelled: 28 Confidence: 60.5% Identity: 21% PDB header:oxidoreductase Chain: O: PDB Molecule:deazaflavin-dependent nitroreductase; PDBTitle: structure of ddn, the deazaflavin-dependent nitroreductase from2 mycobacterium tuberculosis involved in bioreductive activation of pa-3 824, with co-factor f420 Phyre2 PDB 3h96 chain B Region: 221 - 248 Aligned: 28 Modelled: 28 Confidence: 56.2% Identity: 32% PDB header:flavoprotein Chain: B: PDB Molecule:f420-h2 dependent reductase a; PDBTitle: msmeg_3358 f420 reductase Phyre2 PDB 3r5z chain B Region: 221 - 255 Aligned: 35 Modelled: 35 Confidence: 54.6% Identity: 29% PDB header:unknown function Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: structure of a deazaflavin-dependent reductase from nocardia2 farcinica, with co-factor f420 Phyre2 PDB 6hwh chain X Region: 35 - 149 Aligned: 111 Modelled: 115 Confidence: 46.7% Identity: 23% PDB header:electron transport Chain: X: PDB Molecule:cytochrome c oxidase polypeptide 4; PDBTitle: structure of a functional obligate respiratory supercomplex from2 mycobacterium smegmatis Phyre2 PDB 4p63 chain A Region: 217 - 250 Aligned: 34 Modelled: 34 Confidence: 35.8% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:probable deoxyhypusine synthase; PDBTitle: crystal structure of deoxyhypusine synthase from pyrococcus horikoshii Phyre2 PDB 1e7l chain A domain 1 Region: 180 - 188 Aligned: 9 Modelled: 9 Confidence: 32.9% Identity: 56% Fold: LEM/SAP HeH motif Superfamily: Recombination endonuclease VII, C-terminal and dimerization domains Family: Recombination endonuclease VII, C-terminal and dimerization domains Phyre2 PDB 6dft chain J Region: 217 - 250 Aligned: 34 Modelled: 34 Confidence: 26.6% Identity: 18% PDB header:transferase Chain: J: PDB Molecule:deoxyhypusine synthase regulatory subunit; PDBTitle: trypanosoma brucei deoxyhypusine synthase Phyre2 PDB 5ht7 chain A Region: 162 - 183 Aligned: 22 Modelled: 22 Confidence: 24.1% Identity: 27% PDB header:metal binding protein Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a transition-metal-ion-binding betagamma-2 crystallin from methanosaeta thermophila Phyre2 PDB 4hxh chain C Region: 228 - 256 Aligned: 29 Modelled: 29 Confidence: 23.5% Identity: 17% PDB header:rna/rna binding protein/hydrolase Chain: C: PDB Molecule:histone rna hairpin-binding protein; PDBTitle: structure of mrna stem-loop, human stem-loop binding protein and2 3'hexo ternary complex Phyre2 PDB 5e8j chain C Region: 224 - 244 Aligned: 21 Modelled: 21 Confidence: 22.1% Identity: 19% PDB header:translation Chain: C: PDB Molecule:rnmt-activating mini protein; PDBTitle: crystal structure of mrna cap guanine-n7 methyltransferase in complex2 with ram Phyre2 PDB 4q2e chain A Region: 33 - 173 Aligned: 135 Modelled: 141 Confidence: 16.0% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:phosphatidate cytidylyltransferase; PDBTitle: crystal structure of an intramembrane cdp-dag synthetase central for2 phospholipid biosynthesis (s200c/s258c, active mutant) Phyre2 PDB 6ceb chain P Region: 222 - 252 Aligned: 30 Modelled: 31 Confidence: 14.6% Identity: 30% PDB header:signaling protein Chain: P: PDB Molecule:insulin receptor; PDBTitle: insulin receptor ectodomain in complex with two insulin molecules - c12 symmetry Phyre2 PDB 1rgo chain A domain 2 Region: 178 - 183 Aligned: 6 Modelled: 6 Confidence: 14.5% Identity: 83% Fold: CCCH zinc finger Superfamily: CCCH zinc finger Family: CCCH zinc finger Phyre2 PDB 6dft chain E Region: 224 - 248 Aligned: 25 Modelled: 25 Confidence: 12.7% Identity: 12% PDB header:transferase Chain: E: PDB Molecule:deoxyhypusine synthase; PDBTitle: trypanosoma brucei deoxyhypusine synthase Phyre2 PDB 1x9n chain A domain 1 Region: 176 - 183 Aligned: 8 Modelled: 8 Confidence: 12.0% Identity: 13% Fold: ATP-dependent DNA ligase DNA-binding domain Superfamily: ATP-dependent DNA ligase DNA-binding domain Family: ATP-dependent DNA ligase DNA-binding domain Phyre2 1 c4a2nB_ 2 c4quvB_ 3 c5v7pA_ 4 c4y9iA_ 5 c3r5yC_ 6 c3r5wO_ 7 c3h96B_ 8 c3r5zB_ 9 c6hwhX_ 10 c4p63A_ 11 d1e7la1 12 c6dftJ_ 13 c5ht7A_ 14 c4hxhC_ 15 c5e8jC_ 16 c4q2eA_ 17 c6cebP_ 18 d1rgoa2 19 c6dftE_ 20 d1x9na1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66