1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	R	R	A	S	T	D	T	P	Q	I	I	M	G	A	I	G	G	V	V	T	G	Y	I	L	W	L	A	A	I	S	V	G	D	G	L	T	T	V	S	Q	W	S	R	V	V	L	L	L	S	V	L	V	A	V	C	G	A	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?																								?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.
Sequence		G	G	L	R	L	R	S	R	G	K	L	A	W	S	A	F	A	F	S	L	P	I	P	P	V	V	L	T	V	A	V	L	A	D	I	Y	L
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?																								?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 21%) Alpha helix ( 92%) Beta strand ( 0%) TM helix ( 58%) (View membrane topology prediction)

Rank Aligned region

PDB 3vrb chain G Region: 24 - 69 Aligned: 44 Modelled: 46 Confidence: 46.0% Identity: 16% PDB header:oxidoreductase/oxidoreductase inhibitor Chain: G: PDB Molecule:cytochrome b-large subunit; PDBTitle: mitochondrial rhodoquinol-fumarate reductase from the parasitic2 nematode ascaris suum with the specific inhibitor flutolanil and3 substrate fumarate Phyre2 PDB 4rfs chain S Region: 13 - 97 Aligned: 85 Modelled: 85 Confidence: 32.6% Identity: 19% PDB header:hydrolase, transport protein Chain: S: PDB Molecule:substrate binding pritein s; PDBTitle: structure of a pantothenate energy coupling factor transporter Phyre2 PDB 5ir6 chain A Region: 13 - 73 Aligned: 61 Modelled: 61 Confidence: 21.6% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:bd-type quinol oxidase subunit i; PDBTitle: the structure of bd oxidase from geobacillus thermodenitrificans Phyre2 PDB 2l2t chain A Region: 9 - 20 Aligned: 12 Modelled: 12 Confidence: 20.7% Identity: 58% PDB header:membrane protein Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-4; PDBTitle: solution nmr structure of the erbb4 dimeric membrane domain Phyre2 PDB 2lcx chain B Region: 9 - 20 Aligned: 12 Modelled: 12 Confidence: 20.7% Identity: 58% PDB header:transferase Chain: B: PDB Molecule:receptor tyrosine-protein kinase erbb-4; PDBTitle: spatial structure of the erbb4 dimeric tm domain Phyre2 PDB 6adq chain P Region: 25 - 69 Aligned: 45 Modelled: 45 Confidence: 17.7% Identity: 13% PDB header:electron transport Chain: P: PDB Molecule:prokaryotic respiratory supercomplex associate factor 1 PDBTitle: respiratory complex ciii2civ2sod2 from mycobacterium smegmatis Phyre2 PDB 2k9y chain A Region: 15 - 34 Aligned: 20 Modelled: 20 Confidence: 16.0% Identity: 45% PDB header:transferase Chain: A: PDB Molecule:ephrin type-a receptor 2; PDBTitle: epha2 dimeric structure in the lipidic bicelle at ph 5.0 Phyre2 PDB 2k9y chain B Region: 15 - 39 Aligned: 25 Modelled: 25 Confidence: 14.1% Identity: 36% PDB header:transferase Chain: B: PDB Molecule:ephrin type-a receptor 2; PDBTitle: epha2 dimeric structure in the lipidic bicelle at ph 5.0 Phyre2 PDB 3zd0 chain A Region: 49 - 61 Aligned: 13 Modelled: 13 Confidence: 13.3% Identity: 46% PDB header:transport protein Chain: A: PDB Molecule:p7 protein; PDBTitle: the solution structure of monomeric hepatitis c virus p72 yields potent inhibitors of virion release Phyre2 PDB 2m6x chain C Region: 49 - 61 Aligned: 13 Modelled: 13 Confidence: 9.8% Identity: 23% PDB header:membrane protein Chain: C: PDB Molecule:p7; PDBTitle: structure of the p7 channel of hepatitis c virus, genotype 5a Phyre2 PDB 1k82 chain D Region: 11 - 62 Aligned: 52 Modelled: 52 Confidence: 9.7% Identity: 13% PDB header:hydrolase/dna Chain: D: PDB Molecule:formamidopyrimidine-dna glycosylase; PDBTitle: crystal structure of e.coli formamidopyrimidine-dna2 glycosylase (fpg) covalently trapped with dna Phyre2 PDB 1q59 chain A Region: 43 - 57 Aligned: 15 Modelled: 15 Confidence: 8.5% Identity: 13% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 2opf chain A Region: 11 - 56 Aligned: 46 Modelled: 46 Confidence: 8.0% Identity: 17% PDB header:hydrolase/dna Chain: A: PDB Molecule:endonuclease viii; PDBTitle: crystal structure of the dna repair enzyme endonuclease-viii (nei)2 from e. coli (r252a) in complex with ap-site containing dna substrate Phyre2 PDB 5tzp chain A Region: 43 - 58 Aligned: 16 Modelled: 16 Confidence: 7.3% Identity: 13% PDB header:apoptosis Chain: A: PDB Molecule:bcl-2-like protein fpv039; PDBTitle: crystal structure of fpv039:bik bh3 complex Phyre2 PDB 6m97 chain A Region: 23 - 59 Aligned: 26 Modelled: 37 Confidence: 7.1% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:chimera protein of high affinity copper uptake protein 1 PDBTitle: crystal structure of the high-affinity copper transporter ctr1 Phyre2 PDB 1ic8 chain A domain 2 Region: 28 - 70 Aligned: 41 Modelled: 43 Confidence: 6.5% Identity: 12% Fold: lambda repressor-like DNA-binding domains Superfamily: lambda repressor-like DNA-binding domains Family: POU-specific domain Phyre2 PDB 2a5y chain A Region: 43 - 61 Aligned: 19 Modelled: 19 Confidence: 6.5% Identity: 21% PDB header:apoptosis Chain: A: PDB Molecule:apoptosis regulator ced-9; PDBTitle: structure of a ced-4/ced-9 complex Phyre2 PDB 3twk chain B Region: 11 - 60 Aligned: 50 Modelled: 50 Confidence: 6.0% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:formamidopyrimidine-dna glycosylase 1; PDBTitle: crystal structure of arabidopsis thaliana fpg Phyre2 PDB 5vf3 chain Z Region: 60 - 64 Aligned: 5 Modelled: 5 Confidence: 6.0% Identity: 20% PDB header:virus Chain: Z: PDB Molecule:highly immunogenic outer capsid protein; PDBTitle: bacteriophage t4 isometric capsid Phyre2 PDB 4cdi chain C Region: 76 - 96 Aligned: 20 Modelled: 21 Confidence: 5.8% Identity: 35% PDB header:membrane protein Chain: C: PDB Molecule:predicted protein; PDBTitle: crystal structure of acrb-acrz complex Phyre2 1 c3vrbG_ 2 c4rfsS_ 3 c5ir6A_ 4 c2l2tA_ 5 c2lcxB_ 6 c6adqP_ 7 c2k9yA_ 8 c2k9yB_ 9 c3zd0A_ 10 c2m6xC_ 11 c1k82D_ 12 d1q59a_ 13 c2opfA_ 14 c5tzpA_ 15 c6m97A_ 16 d1ic8a2 17 c2a5yA_ 18 c3twkB_ 19 c5vf3Z_ 20 c4cdiC_ 21 22 23 24 25 26 27