1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	V	A	H	R	A	E	V	S	G	S	P	P	P	R	L	N	L	S	T	Q	P	T	V	A	R	R	V	R	A	S	F	A	E	S	F	A	A	A	D	P	E	A	D	A	A	R	R	M	A	L	R	R	M	K	V	V	A	V	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	L	V	G	A	T	G	V	F	L	A	C	R	W	A	Q	A	D	G	A	D	H	A	W	L	G	Y	L	G	A	A	A	E	A	G	M	V	G	A	L	A	D	W	F	A	V	T	A	L	F	K	H	P	L	G	I	P	I	P	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	A	I	I	K	R	K	K	D	Q	L	G	E	G	L	G	T	F	V	R	E	N	F	L	S	P	P	V	V	E	T	K	L	R	D	A	Q	I	P	S	R	L	G	K	W	L	S	E	A	T	H	A	Q	R	V	A	A	E	T	A
Secondary structure
SS confidence
Disorder																																					?	?														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	V	L	R	V	L	V	E	L	L	R	D	E	D	I	Q	Q	V	I	D	R	M	I	V	R	R	I	A	E	P	Q	W	G	P	P	A	G	R	V	L	A	T	L	L	A	E	N	R	Q	E	A	F	I	Q	L	L	A	D	R	A
Secondary structure
SS confidence
Disorder																															?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		F	Q	W	S	L	N	A	G	V	V	I	Q	R	V	V	E	R	D	S	P	S	W	S	P	R	F	I	D	H	L	V	G	D	R	I	H	R	E	L	M	E	F	T	D	K	V	R	R	N	P	D	H	E	L	R	R	S	A	T	R
Secondary structure
SS confidence
Disorder							?																																										?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		F	L	F	D	F	A	D	D	L	Q	H	D	P	A	T	V	A	R	A	D	A	I	K	E	E	L	M	A	R	D	E	I	A	T	A	A	A	A	A	W	K	T	L	K	R	L	V	L	E	G	V	D	D	P	S	S	A	L	R	T
Secondary structure
SS confidence
Disorder												?																																										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	I	T	D	A	V	I	R	I	G	E	S	L	R	D	D	A	D	L	R	D	K	V	D	S	W	T	V	R	A	A	Q	H	L	V	S	E	Y	G	V	E	I	T	A	I	I	T	E	T	I	E	R	W	D	A	E	E	A	S	R
Secondary structure
SS confidence
Disorder																																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.
Sequence		R	I	E	L	H	V	G	R	D	L	Q	F	I	R	I	N	G	T	V	V	G	A	M	A	G	L	A	I	Y	A	I	A	Q	L	L	F
Secondary structure
SS confidence
Disorder																																				?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 76%) Beta strand ( 0%) TM helix ( 13%) (View membrane topology prediction)

Rank Aligned region

PDB 1ug3 chain A Region: 124 - 319 Aligned: 194 Modelled: 196 Confidence: 81.5% Identity: 11% PDB header:translation Chain: A: PDB Molecule:eukaryotic protein synthesis initiation factor PDBTitle: c-terminal portion of human eif4gi Phyre2 PDB 4qmh chain A Region: 188 - 402 Aligned: 213 Modelled: 215 Confidence: 76.8% Identity: 14% PDB header:protein binding Chain: A: PDB Molecule:lp04448p; PDBTitle: the xmap215 family drives microtubule polymerization using a2 structurally diverse tog array Phyre2 PDB 3edy chain A Region: 117 - 170 Aligned: 53 Modelled: 54 Confidence: 61.1% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:tripeptidyl-peptidase 1; PDBTitle: crystal structure of the precursor form of human tripeptidyl-peptidase2 1 Phyre2 PDB 1dvp chain A Region: 194 - 332 Aligned: 136 Modelled: 139 Confidence: 59.5% Identity: 9% PDB header:transferase Chain: A: PDB Molecule:hepatocyte growth factor-regulated tyrosine PDBTitle: crystal structure of the vhs and fyve tandem domains of hrs,2 a protein involved in membrane trafficking and signal3 transduction Phyre2 PDB 5jnm chain A Region: 370 - 443 Aligned: 74 Modelled: 74 Confidence: 54.3% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:mannitol-1-phosphate 5-dehydrogenase; PDBTitle: crystal structure of mtld from staphylococcus aureus at 1.7-angstrom2 resolution Phyre2 PDB 1mhq chain A Region: 195 - 327 Aligned: 133 Modelled: 133 Confidence: 54.0% Identity: 12% Fold: alpha-alpha superhelix Superfamily: ENTH/VHS domain Family: VHS domain Phyre2 PDB 1dvp chain A domain 1 Region: 194 - 332 Aligned: 136 Modelled: 139 Confidence: 52.8% Identity: 9% Fold: alpha-alpha superhelix Superfamily: ENTH/VHS domain Family: VHS domain Phyre2 PDB 6ith chain A Region: 437 - 456 Aligned: 19 Modelled: 20 Confidence: 50.6% Identity: 26% PDB header:membrane protein Chain: A: PDB Molecule:syndecan-2; PDBTitle: structure of the transmembrane domain of syndecan 2 in micelles Phyre2 PDB 1t1e chain A domain 2 Region: 117 - 170 Aligned: 53 Modelled: 54 Confidence: 48.1% Identity: 13% Fold: Ferredoxin-like Superfamily: Protease propeptides/inhibitors Family: Subtilase propeptides/inhibitors Phyre2 PDB 3ee6 chain A Region: 117 - 170 Aligned: 54 Modelled: 54 Confidence: 47.7% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:tripeptidyl-peptidase 1; PDBTitle: crystal structure analysis of tripeptidyl peptidase -i Phyre2 PDB 4mud chain A Region: 119 - 312 Aligned: 173 Modelled: 186 Confidence: 46.2% Identity: 9% PDB header:oxidoreductase Chain: A: PDB Molecule:ring oxydation complex/ phenylacetic acid degradation PDBTitle: crystal structure of a ring oxydation complex/ phenylacetic acid2 degradation-like protein (sso1313) from sulfolobus solfataricus p2 at3 2.43 a resolution Phyre2 PDB 3rru chain A Region: 194 - 325 Aligned: 132 Modelled: 132 Confidence: 45.9% Identity: 9% PDB header:signaling protein Chain: A: PDB Molecule:tom1l1 protein; PDBTitle: x-ray crystal structure of the vhs domain of human tom1-like protein,2 northeast structural genomics consortium target hr3050e Phyre2 PDB 3j3b chain D Region: 115 - 231 Aligned: 85 Modelled: 95 Confidence: 45.0% Identity: 14% PDB header:ribosome Chain: D: PDB Molecule:60s ribosomal protein l5; PDBTitle: structure of the human 60s ribosomal proteins Phyre2 PDB 6e8w chain C Region: 430 - 446 Aligned: 17 Modelled: 17 Confidence: 43.1% Identity: 47% PDB header:viral protein Chain: C: PDB Molecule:envelope glycoprotein gp160; PDBTitle: mper-tm domain of hiv-1 envelope glycoprotein (env) Phyre2 PDB 6dln chain B Region: 430 - 448 Aligned: 19 Modelled: 19 Confidence: 41.5% Identity: 37% PDB header:membrane protein Chain: B: PDB Molecule:transmembrane protein gp41; PDBTitle: oligomeric structure of the hiv gp41 mper-tmd in phospholipid bilayers Phyre2 PDB 3zyq chain A Region: 194 - 324 Aligned: 128 Modelled: 131 Confidence: 41.0% Identity: 11% PDB header:signaling Chain: A: PDB Molecule:hepatocyte growth factor-regulated tyrosine kinase PDBTitle: crystal structure of the tandem vhs and fyve domains of hepatocyte2 growth factor-regulated tyrosine kinase substrate (hgs-hrs) at 1.48 a3 resolution Phyre2 PDB 5d8m chain A Region: 101 - 143 Aligned: 39 Modelled: 43 Confidence: 39.0% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:metagenomic carboxyl esterase mgs0156; PDBTitle: crystal structure of the metagenomic carboxyl esterase mgs0156 Phyre2 PDB 2k7r chain A Region: 302 - 338 Aligned: 37 Modelled: 37 Confidence: 38.7% Identity: 14% PDB header:replication Chain: A: PDB Molecule:primosomal protein dnai; PDBTitle: n-terminal domain of the bacillus subtilis helicase-loading2 protein dnai Phyre2 PDB 1x5b chain A Region: 195 - 324 Aligned: 127 Modelled: 130 Confidence: 36.8% Identity: 9% PDB header:protein binding Chain: A: PDB Molecule:signal transducing adaptor molecule 2; PDBTitle: the solution structure of the vhs domain of human signal2 transducing adaptor molecule 2 Phyre2 PDB 6hum chain Q Region: 439 - 451 Aligned: 13 Modelled: 13 Confidence: 33.1% Identity: 38% PDB header:proton transport Chain: Q: PDB Molecule:proton-translocating nadh-quinone dehydrogenase subunit q PDBTitle: structure of the photosynthetic complex i from thermosynechococcus2 elongatus Phyre2 1 c1ug3A_ 2 c4qmhA_ 3 c3edyA_ 4 c1dvpA_ 5 c5jnmA_ 6 d1mhqa_ 7 d1dvpa1 8 c6ithA_ 9 d1t1ea2 10 c3ee6A_ 11 c4mudA_ 12 c3rruA_ 13 c3j3bD_ 14 c6e8wC_ 15 c6dlnB_ 16 c3zyqA_ 17 c5d8mA_ 18 c2k7rA_ 19 c1x5bA_ 20 c6humQ_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99