1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	R	S	G	V	G	S	L	F	A	G	A	H	I	A	E	A	V	P	L	A	P	L	T	T	L	R	V	G	P	I	A	R	R	V	I	T	C	T	S	A	E	Q	V	V	A	A	L	R	H	L	D	S	A	A	K	T	G	A
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	R	P	L	V	F	A	G	G	S	N	L	V	I	A	E	N	L	T	D	L	T	V	V	R	L	A	N	S	G	I	T	I	D	G	N	L	V	R	A	E	A	G	A	V	F	D	D	V	V	V	R	A	I	E	Q	G	L	G	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	E	C	L	S	G	I	P	G	S	A	G	A	T	P	V	Q	N	V	G	A	Y	G	A	E	V	S	D	T	I	T	R	V	R	L	L	D	R	C	T	G	E	V	R	W	V	S	A	R	D	L	R	F	G	Y	R	T	S	V	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		K	H	A	D	G	L	A	V	P	T	V	V	L	E	V	E	F	A	L	D	P	S	G	R	S	A	P	L	R	Y	G	E	L	I	A	A	L	N	A	T	S	G	E	R	A	D	P	Q	A	V	R	E	A	V	L	A	L	R	A	R
Secondary structure
SS confidence
Disorder			?	?	?	?																	?	?	?	?	?	?										?		?	?	?	?	?	?	?															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		K	G	M	V	L	D	P	T	D	H	D	T	W	S	V	G	S	F	F	T	N	P	V	V	T	Q	D	V	Y	E	R	L	A	G	D	A	A	T	R	K	D	G	P	V	P	H	Y	P	A	P	D	G	V	K	L	A	A	G	W	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?																													?											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	E	R	A	G	F	G	K	G	Y	P	D	A	G	A	A	P	C	R	L	S	T	K	H	A	L	A	L	T	N	R	G	G	A	T	A	E	D	V	V	T	L	A	R	A	V	R	D	G	V	H	D	V	F	G	I	T	L	K	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.
Sequence		E	P	V	L	I	G	C	M	L
Secondary structure
SS confidence
Disorder								?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 28%) Beta strand ( 24%)

Rank Aligned region

PDB 5jzx chain B Region: 10 - 368 Aligned: 327 Modelled: 332 Confidence: 100.0% Identity: 97% PDB header:oxidoreductase Chain: B: PDB Molecule:udp-n-acetylenolpyruvoylglucosamine reductase; PDBTitle: crystal structure of udp-n-acetylenolpyruvoylglucosamine reductase2 (murb) from mycobacterium tuberculosis Phyre2 PDB 3i99 chain A Region: 12 - 368 Aligned: 332 Modelled: 354 Confidence: 100.0% Identity: 34% PDB header:oxidoreductase Chain: A: PDB Molecule:udp-n-acetylenolpyruvoylglucosamine reductase; PDBTitle: the crystal structure of the udp-n-acetylenolpyruvoylglucosamine2 reductase from the vibrio cholerae o1 biovar tor Phyre2 PDB 1mbb chain A Region: 19 - 368 Aligned: 327 Modelled: 350 Confidence: 100.0% Identity: 32% PDB header:oxidoreductase Chain: A: PDB Molecule:uridine diphospho-n-acetylenolpyruvylglucosamine PDBTitle: oxidoreductase Phyre2 PDB 4jay chain C Region: 12 - 364 Aligned: 332 Modelled: 353 Confidence: 100.0% Identity: 36% PDB header:oxidoreductase Chain: C: PDB Molecule:udp-n-acetylenolpyruvoylglucosamine reductase; PDBTitle: crystal structure of p. aeruginosa murb in complex with nadp+ Phyre2 PDB 1hsk chain A Region: 4 - 366 Aligned: 293 Modelled: 307 Confidence: 100.0% Identity: 33% PDB header:oxidoreductase Chain: A: PDB Molecule:udp-n-acetylenolpyruvoylglucosamine reductase; PDBTitle: crystal structure of s. aureus murb Phyre2 PDB 4pyt chain A Region: 4 - 366 Aligned: 293 Modelled: 313 Confidence: 100.0% Identity: 31% PDB header:oxidoreductase Chain: A: PDB Molecule:udp-n-acetylenolpyruvoylglucosamine reductase; PDBTitle: crystal structure of a murb family ep-udp-n-acetylglucosamine2 reductase Phyre2 PDB 2gqu chain A Region: 13 - 362 Aligned: 263 Modelled: 291 Confidence: 100.0% Identity: 34% PDB header:oxidoreductase Chain: A: PDB Molecule:udp-n-acetylenolpyruvylglucosamine reductase; PDBTitle: crystal structure of udp-n-acetylenolpyruvylglucosamine2 reductase (murb) from thermus caldophilus Phyre2 PDB 1uxy chain A domain 2 Region: 225 - 368 Aligned: 132 Modelled: 144 Confidence: 100.0% Identity: 39% Fold: Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain Superfamily: Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain Family: Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain Phyre2 PDB 1uxy chain A domain 1 Region: 19 - 220 Aligned: 195 Modelled: 202 Confidence: 100.0% Identity: 27% Fold: FAD-binding/transporter-associated domain-like Superfamily: FAD-binding/transporter-associated domain-like Family: Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain Phyre2 PDB 1hsk chain A domain 1 Region: 4 - 201 Aligned: 188 Modelled: 198 Confidence: 100.0% Identity: 32% Fold: FAD-binding/transporter-associated domain-like Superfamily: FAD-binding/transporter-associated domain-like Family: Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain Phyre2 PDB 1hsk chain A domain 2 Region: 222 - 366 Aligned: 105 Modelled: 115 Confidence: 100.0% Identity: 37% Fold: Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain Superfamily: Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain Family: Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain Phyre2 PDB 4ml8 chain C Region: 3 - 204 Aligned: 193 Modelled: 202 Confidence: 99.5% Identity: 18% PDB header:oxidoreductase Chain: C: PDB Molecule:cytokinin oxidase 2; PDBTitle: structure of maize cytokinin oxidase/dehydrogenase 2 (zmcko2) Phyre2 PDB 4oal chain B Region: 34 - 204 Aligned: 161 Modelled: 171 Confidence: 99.5% Identity: 18% PDB header:oxidoreductase Chain: B: PDB Molecule:cytokinin dehydrogenase 4; PDBTitle: crystal structure of maize cytokinin oxidase/dehydrogenase 4 (zmcko4)2 in complex with phenylurea inhibitor cppu in alternative spacegroup Phyre2 PDB 3fwa chain A Region: 34 - 204 Aligned: 160 Modelled: 171 Confidence: 99.5% Identity: 15% PDB header:flavoprotein Chain: A: PDB Molecule:reticuline oxidase; PDBTitle: structure of berberine bridge enzyme, c166a variant in complex with2 (s)-reticuline Phyre2 PDB 1wvf chain A domain 2 Region: 24 - 203 Aligned: 175 Modelled: 180 Confidence: 99.5% Identity: 17% Fold: FAD-binding/transporter-associated domain-like Superfamily: FAD-binding/transporter-associated domain-like Family: FAD-linked oxidases, N-terminal domain Phyre2 PDB 4ud8 chain B Region: 35 - 204 Aligned: 159 Modelled: 170 Confidence: 99.5% Identity: 23% PDB header:oxidoreductase Chain: B: PDB Molecule:fad-binding and bbe domain-containing protein; PDBTitle: atbbe15 Phyre2 PDB 3vte chain A Region: 32 - 204 Aligned: 162 Modelled: 173 Confidence: 99.5% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:tetrahydrocannabinolic acid synthase; PDBTitle: crystal structure of tetrahydrocannabinolic acid synthase from2 cannabis sativa Phyre2 PDB 5d79 chain B Region: 35 - 204 Aligned: 155 Modelled: 170 Confidence: 99.5% Identity: 17% PDB header:oxidoreductase Chain: B: PDB Molecule:berberine bridge enzyme-like protein; PDBTitle: structure of bbe-like #28 from arabidopsis thaliana Phyre2 PDB 3w8w chain A Region: 29 - 204 Aligned: 163 Modelled: 176 Confidence: 99.5% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:putative fad-dependent oxygenase encm; PDBTitle: the crystal structure of encm Phyre2 PDB 1zr6 chain A Region: 35 - 204 Aligned: 156 Modelled: 170 Confidence: 99.5% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:glucooligosaccharide oxidase; PDBTitle: the crystal structure of an acremonium strictum glucooligosaccharide2 oxidase reveals a novel flavinylation Phyre2 1 c5jzxB_ 2 c3i99A_ 3 c1mbbA_ 4 c4jayC_ 5 c1hskA_ 6 c4pytA_ 7 c2gquA_ 8 d1uxya2 9 d1uxya1 10 d1hska1 11 d1hska2 12 c4ml8C_ 13 c4oalB_ 14 c3fwaA_ 15 d1wvfa2 16 c4ud8B_ 17 c3vteA_ 18 c5d79B_ 19 c3w8wA_ 20 c1zr6A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99