1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	V	D	A	H	R	G	G	H	P	T	P	M	S	S	T	K	A	T	L	R	L	A	E	A	T	D	S	S	G	K	I	T	K	R	G	A	D	K	L	I	S	T	I	D	E	F	A	K	I	A	I	S	S	G	C	A	E	L	M
Secondary structure
SS confidence
Disorder		?			?	?	?	?																?					?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	F	A	T	S	A	V	R	D	A	E	N	S	E	D	V	L	S	R	V	R	K	E	T	G	V	E	L	Q	A	L	R	G	E	D	E	S	R	L	T	F	L	A	V	R	R	W	Y	G	W	S	A	G	R	I	L	N	L	D	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	G	G	S	L	E	V	S	S	G	V	D	E	E	P	E	I	A	L	S	L	P	L	G	A	G	R	L	T	R	E	W	L	P	D	D	P	P	G	R	R	R	V	A	M	L	R	D	W	L	D	A	E	L	A	E	P	S	V	T
Secondary structure
SS confidence
Disorder																																			?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	L	E	A	G	S	P	D	L	A	V	A	T	S	K	T	F	R	S	L	A	R	L	T	G	A	A	P	S	M	A	G	P	R	V	K	R	T	L	T	A	N	G	L	R	Q	L	I	A	F	I	S	R	M	T	A	V	D	R	A
Secondary structure
SS confidence
Disorder																													?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	L	E	G	V	S	A	D	R	A	P	Q	I	V	A	G	A	L	V	A	E	A	S	M	R	A	L	S	I	E	A	V	E	I	C	P	W	A	L	R	E	G	L	I	L	R	K	L	D	S	E	A	D	G	T	A	L	I	E	S
Secondary structure
SS confidence
Disorder					?																																																?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.
Sequence		S	S	V	H	T	S	V	R	A	V	G	G	Q	P	A	D	R	N	A	A	N	R	S	R	G	S	K	P
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?				?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 55%) Beta strand ( 17%)

Rank Aligned region

PDB 2flo chain A Region: 1 - 315 Aligned: 306 Modelled: 315 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:exopolyphosphatase; PDBTitle: crystal structure of exopolyphosphatase (ppx) from e. coli o157:h7 Phyre2 PDB 3cer chain D Region: 1 - 290 Aligned: 289 Modelled: 290 Confidence: 100.0% Identity: 22% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:possible exopolyphosphatase-like protein; PDBTitle: crystal structure of the exopolyphosphatase-like protein q8g5j2.2 northeast structural genomics consortium target blr13 Phyre2 PDB 3mdq chain A Region: 1 - 290 Aligned: 288 Modelled: 290 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:exopolyphosphatase; PDBTitle: crystal structure of an exopolyphosphatase (chu_0316) from cytophaga2 hutchinsonii atcc 33406 at 1.50 a resolution Phyre2 PDB 3hi0 chain B Region: 1 - 315 Aligned: 293 Modelled: 312 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:putative exopolyphosphatase; PDBTitle: crystal structure of putative exopolyphosphatase (17739545) from2 agrobacterium tumefaciens str. c58 (dupont) at 2.30 a resolution Phyre2 PDB 1t6d chain B Region: 1 - 288 Aligned: 279 Modelled: 287 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: B: PDB Molecule:exopolyphosphatase; PDBTitle: miras phasing of the aquifex aeolicus ppx/gppa phosphatase: crystal2 structure of the type ii variant Phyre2 PDB 1t6c chain A domain 2 Region: 111 - 294 Aligned: 178 Modelled: 184 Confidence: 100.0% Identity: 24% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: Ppx/GppA phosphatase Phyre2 PDB 1u6z chain A domain 3 Region: 112 - 294 Aligned: 177 Modelled: 183 Confidence: 100.0% Identity: 22% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: Ppx/GppA phosphatase Phyre2 PDB 1t6c chain A domain 1 Region: 1 - 108 Aligned: 107 Modelled: 108 Confidence: 100.0% Identity: 23% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: Ppx/GppA phosphatase Phyre2 PDB 1u6z chain A domain 2 Region: 1 - 109 Aligned: 108 Modelled: 109 Confidence: 100.0% Identity: 19% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: Ppx/GppA phosphatase Phyre2 PDB 3aap chain A Region: 6 - 270 Aligned: 254 Modelled: 265 Confidence: 99.8% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:ectonucleoside triphosphate diphosphohydrolase i; PDBTitle: crystal structure of lp1ntpdase from legionella pneumophila Phyre2 PDB 5u7x chain F Region: 1 - 265 Aligned: 259 Modelled: 265 Confidence: 99.7% Identity: 17% PDB header:hydrolase Chain: F: PDB Molecule:nod factor binding lectin-nucleotide phosphohydrolase; PDBTitle: crystal structure of a nucleoside triphosphate diphosphohydrolase2 (ntpdase) from the legume vigna unguiculata subsp. cylindrica3 (dolichos biflorus) in complex with phosphate and manganese Phyre2 PDB 5u7w chain A Region: 1 - 270 Aligned: 265 Modelled: 270 Confidence: 99.7% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:apyrase; PDBTitle: crystal structure of a nucleoside triphosphate diphosphohydrolase2 (ntpdase) from the legume trifolium repens in complex with adenine3 and phosphate Phyre2 PDB 3zx2 chain A Region: 1 - 276 Aligned: 264 Modelled: 276 Confidence: 99.7% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:ectonucleoside triphosphate diphosphohydrolase 1; PDBTitle: ntpdase1 in complex with decavanadate Phyre2 PDB 3cj9 chain A Region: 1 - 270 Aligned: 263 Modelled: 270 Confidence: 99.3% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:ectonucleoside triphosphate diphosphohydrolase 2; PDBTitle: structure of rattus norvegicus ntpdase2 in complex with2 calcium, amp and phosphate Phyre2 PDB 3agr chain B Region: 34 - 129 Aligned: 96 Modelled: 96 Confidence: 98.7% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:nucleoside triphosphate hydrolase; PDBTitle: crystal structure of nucleoside triphosphate hydrolases from neospora2 caninum Phyre2 PDB 3h1q chain B Region: 1 - 198 Aligned: 182 Modelled: 197 Confidence: 98.7% Identity: 15% PDB header:structural protein Chain: B: PDB Molecule:ethanolamine utilization protein eutj; PDBTitle: crystal structure of ethanolamine utilization protein eutj from2 carboxydothermus hydrogenoformans Phyre2 PDB 4a5b chain A Region: 23 - 129 Aligned: 107 Modelled: 107 Confidence: 98.6% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:nucleoside-triphosphatase 2; PDBTitle: crystal structure of the c258s/c268s variant of toxoplasma gondii2 nucleoside triphosphate diphosphohydrolase 1 (ntpdase1) Phyre2 PDB 5eox chain B Region: 79 - 198 Aligned: 119 Modelled: 120 Confidence: 98.2% Identity: 13% PDB header:peptide binding protein Chain: B: PDB Molecule:type 4 fimbrial biogenesis protein pilm; PDBTitle: pseudomonas aeruginosa pilm bound to adp Phyre2 PDB 1e4g chain T Region: 75 - 211 Aligned: 134 Modelled: 135 Confidence: 98.1% Identity: 10% PDB header:bacterial cell division Chain: T: PDB Molecule:cell division protein ftsa; PDBTitle: ftsa (atp-bound form) from thermotoga maritima Phyre2 PDB 4cze chain A Region: 33 - 196 Aligned: 159 Modelled: 164 Confidence: 98.0% Identity: 16% PDB header:structural protein Chain: A: PDB Molecule:rod shape-determining protein mreb; PDBTitle: c. crescentus mreb, double filament, empty Phyre2 1 c2floA_ 2 c3cerD_ 3 c3mdqA_ 4 c3hi0B_ 5 c1t6dB_ 6 d1t6ca2 7 d1u6za3 8 d1t6ca1 9 d1u6za2 10 c3aapA_ 11 c5u7xF_ 12 c5u7wA_ 13 c3zx2A_ 14 c3cj9A_ 15 c3agrB_ 16 c3h1qB_ 17 c4a5bA_ 18 c5eoxB_ 19 c1e4gT_ 20 c4czeA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177