1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	G	N	V	A	G	E	T	R	A	N	V	I	P	L	H	T	N	R	S	R	V	A	A	R	R	R	A	G	Q	R	A	E	S	R	Q	H	P	S	L	L	S	D	P	N	D	R	A	S	A	E	Q	I	A	A	V	V	R	E	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?			?				?						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	E	H	R	R	A	A	G	A	T	T	S	S	T	E	A	T	P	N	D	L	A	Q	L	V	A	A	V	A	G	F	L	R	Q	R	L	T	G	D	Y	S	V	D	E	F	G	F	D	P	H	F	N	S	A	I	V	R	P	L	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?		?	?	?	?	?	?	?	?															?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	F	F	F	K	S	W	F	R	V	E	V	S	G	V	E	N	I	P	R	D	G	A	A	L	V	V	A	N	H	A	G	V	L	P	F	D	G	L	M	L	S	V	A	V	H	D	E	H	P	A	H	R	D	L	R	L	L	A	A
Secondary structure
SS confidence
Disorder																																															?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	M	V	F	D	L	P	V	I	G	E	A	A	R	K	A	G	H	T	M	A	C	T	T	D	A	H	R	L	L	A	S	G	E	L	T	A	V	F	P	E	G	Y	K	G	L	G	K	R	F	E	D	R	Y	R	L	Q	R	F	G
Secondary structure
SS confidence
Disorder																																															?	?	?	?	?		?	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	G	G	F	V	S	A	A	L	R	T	K	A	P	I	V	P	C	S	I	I	G	S	E	E	I	Y	P	M	L	T	D	V	K	L	L	A	R	L	F	G	L	P	Y	F	P	I	T	P	L	F	P	L	A	G	P	V	G	L	V
Secondary structure
SS confidence
Disorder																																	?	?	?	?	?						?	?						?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.
Sequence		P	L	P	S	K	W	R	I	A	F	G	E	P	I	C	T	A	D	Y	A	S	T	D	A	D	D	P	M	V	T	F	E	L	T	D	Q	V	R	E	T	I	Q	Q	T	L	Y	R	L	L	A	G	R	R	N	I	F	F	G
Secondary structure
SS confidence
Disorder																				?	?	?	?	?	?	?	?																										?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 32%) Alpha helix ( 44%) Beta strand ( 11%) TM helix ( 9%) (View membrane topology prediction)

Rank Aligned region

PDB 5kym chain A Region: 109 - 351 Aligned: 192 Modelled: 216 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:1-acyl-sn-glycerol-3-phosphate acyltransferase; PDBTitle: crystal structure of the 1-acyl-sn-glycerophosphate (lpa)2 acyltransferase, plsc, from thermotoga maritima Phyre2 PDB 5f34 chain A Region: 129 - 343 Aligned: 162 Modelled: 176 Confidence: 99.5% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol mannoside acyltransferase; PDBTitle: crystal structure of membrane associated pata from mycobacterium2 smegmatis in complex with s-hexadecyl coenzyme a - p21 space group Phyre2 PDB 5knk chain B Region: 107 - 343 Aligned: 185 Modelled: 193 Confidence: 99.3% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:lipid a biosynthesis lauroyl acyltransferase; PDBTitle: lipid a secondary acyltransferase lpxm from acinetobacter baumannii2 with catalytic residue substitution (e127a) Phyre2 PDB 1iuq chain A Region: 144 - 350 Aligned: 177 Modelled: 179 Confidence: 98.5% Identity: 16% Fold: Glycerol-3-phosphate (1)-acyltransferase Superfamily: Glycerol-3-phosphate (1)-acyltransferase Family: Glycerol-3-phosphate (1)-acyltransferase Phyre2 PDB 1j1i chain A Region: 45 - 95 Aligned: 51 Modelled: 51 Confidence: 34.4% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:meta cleavage compound hydrolase; PDBTitle: crystal structure of a his-tagged serine hydrolase involved2 in the carbazole degradation (carc enzyme) Phyre2 PDB 1j1i chain A Region: 45 - 95 Aligned: 51 Modelled: 51 Confidence: 34.4% Identity: 14% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Carbon-carbon bond hydrolase Phyre2 PDB 1ems chain B Region: 203 - 260 Aligned: 58 Modelled: 58 Confidence: 21.8% Identity: 7% PDB header:antitumor protein Chain: B: PDB Molecule:nit-fragile histidine triad fusion protein; PDBTitle: crystal structure of the c. elegans nitfhit protein Phyre2 PDB 3bdi chain A Region: 45 - 94 Aligned: 50 Modelled: 50 Confidence: 17.6% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized protein ta0194; PDBTitle: crystal structure of predicted cib-like hydrolase (np_393672.1) from2 thermoplasma acidophilum at 1.45 a resolution Phyre2 PDB 1q0r chain A Region: 25 - 95 Aligned: 71 Modelled: 71 Confidence: 17.1% Identity: 11% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Aclacinomycin methylesterase RdmC Phyre2 PDB 1wpr chain A Region: 39 - 96 Aligned: 58 Modelled: 58 Confidence: 17.0% Identity: 5% PDB header:signaling protein Chain: A: PDB Molecule:sigma factor sigb regulation protein rsbq; PDBTitle: crystal structure of rsbq inhibited by pmsf Phyre2 PDB 5d6o chain B Region: 39 - 94 Aligned: 56 Modelled: 56 Confidence: 15.9% Identity: 7% PDB header:transferase Chain: B: PDB Molecule:homoserine o-acetyltransferase; PDBTitle: orthorhombic crystal structure of an acetylester hydrolase from2 corynebacterium glutamicum Phyre2 PDB 4uhh chain A Region: 45 - 94 Aligned: 50 Modelled: 50 Confidence: 14.9% Identity: 10% PDB header:hydrolase Chain: A: PDB Molecule:esterase; PDBTitle: structural studies of a thermophilic esterase from2 thermogutta terrifontis (cacodylate complex) Phyre2 PDB 1u2e chain A Region: 39 - 94 Aligned: 56 Modelled: 56 Confidence: 14.9% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:2-hydroxy-6-ketonona-2,4-dienedioic acid PDBTitle: crystal structure of the c-c bond hydrolase mhpc Phyre2 PDB 4wwr chain E Region: 312 - 345 Aligned: 34 Modelled: 34 Confidence: 14.6% Identity: 29% PDB header:transport protein Chain: E: PDB Molecule:large proline-rich protein bag6; PDBTitle: crystal structure of bag6-ubl4a dimerization domain Phyre2 PDB 4psu chain A Region: 39 - 94 Aligned: 56 Modelled: 56 Confidence: 13.3% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:alpha/beta hydrolase; PDBTitle: crystal structure of alpha/beta hydrolase from rhodopseudomonas2 palustris cga009 Phyre2 PDB 2ock chain A Region: 39 - 93 Aligned: 55 Modelled: 55 Confidence: 13.1% Identity: 9% PDB header:hydrolase Chain: A: PDB Molecule:valacyclovir hydrolase; PDBTitle: crystal structure of valacyclovir hydrolase d123n mutant Phyre2 PDB 4q3l chain C Region: 39 - 94 Aligned: 56 Modelled: 56 Confidence: 12.0% Identity: 14% PDB header:hydrolase Chain: C: PDB Molecule:mgs-m2; PDBTitle: crystal structure of mgs-m2, an alpha/beta hydrolase enzyme from a2 medee basin deep-sea metagenome library Phyre2 PDB 3wrb chain B Region: 253 - 303 Aligned: 51 Modelled: 51 Confidence: 11.8% Identity: 16% PDB header:oxidoreductase Chain: B: PDB Molecule:gallate dioxygenase; PDBTitle: crystal structure of the anaerobic h124f desb-gallate complex Phyre2 PDB 5nfq chain A Region: 39 - 94 Aligned: 56 Modelled: 56 Confidence: 11.8% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:epoxide hydrolase belonging to alpha/beta hydrolase PDBTitle: novel epoxide hydrolases belonging to the alpha/beta hydrolases2 superfamily in metagenomes from hot environments Phyre2 PDB 1c4x chain A Region: 39 - 93 Aligned: 55 Modelled: 55 Confidence: 11.6% Identity: 9% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Carbon-carbon bond hydrolase Phyre2 1 c5kymA_ 2 c5f34A_ 3 c5knkB_ 4 d1iuqa_ 5 c1j1iA_ 6 d1j1ia_ 7 c1emsB_ 8 c3bdiA_ 9 d1q0ra_ 10 c1wprA_ 11 c5d6oB_ 12 c4uhhA_ 13 c1u2eA_ 14 c4wwrE_ 15 c4psuA_ 16 c2ockA_ 17 c4q3lC_ 18 c3wrbB_ 19 c5nfqA_ 20 d1c4xa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75