1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	E	A	A	Q	A	L	G	F	E	V	L	D	Q	R	D	L	V	R	N	L	R	T	H	Y	S	R	V	F	E	E	L	E	A	R	R	L	E	L	E	G	K	S	S	Q	E	Y	L	D	K	M	R	V	G	L	K	N	W	V
Secondary structure
SS confidence
Disorder		?																																									?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.
Sequence		E	A	A	D	N	G	H	S	R	V	G	H	P	T	F	P	R	T	R	L	T	P	I	C	Q	L	P	T	A	A	I	D	S	T	A	G	R	R	R	Y	R
Secondary structure
SS confidence
Disorder																			?					?		?			?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 21%) Alpha helix ( 84%) Beta strand ( 0%)

Rank Aligned region

PDB 2o57 chain A domain 1 Region: 2 - 67 Aligned: 66 Modelled: 66 Confidence: 98.8% Identity: 30% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Mycolic acid cyclopropane synthase Phyre2 PDB 5gm2 chain E Region: 1 - 70 Aligned: 70 Modelled: 70 Confidence: 97.3% Identity: 21% PDB header:transferase Chain: E: PDB Molecule:o-methylransferase; PDBTitle: crystal structure of methyltransferase tled complexed with sah and2 teleocidin a1 Phyre2 PDB 5wp5 chain A Region: 2 - 71 Aligned: 70 Modelled: 70 Confidence: 97.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:phosphomethylethanolamine n-methyltransferase 2; PDBTitle: arabidopsis thaliana phosphoethanolamine n-methyltransferase 22 (atpmt2) in complex with sah Phyre2 PDB 4iv0 chain B Region: 1 - 71 Aligned: 71 Modelled: 71 Confidence: 96.9% Identity: 11% PDB header:transferase Chain: B: PDB Molecule:phosphoethanolamine n-methyltransferase, putative; PDBTitle: crystal structure of n-methyl transferase from plasmodium vivax2 complexed with s-adenosyl methionine and phosphate Phyre2 PDB 2fk8 chain A Region: 1 - 77 Aligned: 77 Modelled: 77 Confidence: 96.8% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:methoxy mycolic acid synthase 4; PDBTitle: crystal structure of hma (mmaa4) from mycobacterium tuberculosis2 complexed with s-adenosylmethionine Phyre2 PDB 1tpy chain A Region: 1 - 77 Aligned: 77 Modelled: 77 Confidence: 96.2% Identity: 17% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Mycolic acid cyclopropane synthase Phyre2 PDB 1kpg chain A Region: 1 - 77 Aligned: 77 Modelled: 77 Confidence: 95.5% Identity: 21% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Mycolic acid cyclopropane synthase Phyre2 PDB 3bus chain B Region: 2 - 67 Aligned: 66 Modelled: 66 Confidence: 95.4% Identity: 18% PDB header:transferase Chain: B: PDB Molecule:methyltransferase; PDBTitle: crystal structure of rebm Phyre2 PDB 2fk8 chain A domain 1 Region: 1 - 77 Aligned: 77 Modelled: 77 Confidence: 95.3% Identity: 14% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Mycolic acid cyclopropane synthase Phyre2 PDB 1l1e chain A Region: 2 - 77 Aligned: 76 Modelled: 76 Confidence: 94.8% Identity: 21% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Mycolic acid cyclopropane synthase Phyre2 PDB 4krh chain B Region: 2 - 67 Aligned: 66 Modelled: 66 Confidence: 93.5% Identity: 18% PDB header:transferase Chain: B: PDB Molecule:phosphoethanolamine n-methyltransferase 2; PDBTitle: semet haemonchus contortus phosphoethanolamine n-methyltransferase 22 in complex with s-adenosyl-l-methionine Phyre2 PDB 1kpi chain A Region: 1 - 77 Aligned: 77 Modelled: 77 Confidence: 93.1% Identity: 16% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Mycolic acid cyclopropane synthase Phyre2 PDB 4ine chain B Region: 1 - 71 Aligned: 71 Modelled: 71 Confidence: 93.0% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:protein pmt-2; PDBTitle: crystal structure of n-methyl transferase (pmt-2) from caenorhabditis2 elegant complexed with s-adenosyl homocysteine and3 phosphoethanolamine Phyre2 PDB 5z9o chain A Region: 1 - 79 Aligned: 79 Modelled: 79 Confidence: 92.7% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:cyclopropane-fatty-acyl-phospholipid synthase; PDBTitle: the crystal structure of cyclopropane-fatty-acyl-phospholipid synthase2 from lactobacillus acidophilus Phyre2 PDB 3ujc chain A Region: 1 - 71 Aligned: 71 Modelled: 71 Confidence: 92.3% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:phosphoethanolamine n-methyltransferase; PDBTitle: phosphoethanolamine methyltransferase mutant (h132a) from plasmodium2 falciparum in complex with phosphocholine Phyre2 PDB 4pne chain A Region: 1 - 67 Aligned: 67 Modelled: 67 Confidence: 89.4% Identity: 24% PDB header:biosynthetic protein Chain: A: PDB Molecule:methyltransferase-like protein; PDBTitle: crystal structure of the [4+2]-cyclase spnf Phyre2 PDB 6bqc chain A Region: 3 - 79 Aligned: 77 Modelled: 77 Confidence: 78.5% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:cyclopropane-fatty-acyl-phospholipid synthase; PDBTitle: cyclopropane fatty acid synthase from e. coli Phyre2 PDB 1nkv chain A Region: 2 - 64 Aligned: 63 Modelled: 63 Confidence: 75.7% Identity: 19% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Hypothetical Protein YjhP Phyre2 PDB 1q08 chain A Region: 4 - 96 Aligned: 80 Modelled: 82 Confidence: 43.4% Identity: 21% Fold: Putative DNA-binding domain Superfamily: Putative DNA-binding domain Family: DNA-binding N-terminal domain of transcription activators Phyre2 PDB 2rq5 chain A Region: 2 - 50 Aligned: 48 Modelled: 49 Confidence: 34.5% Identity: 17% PDB header:transcription Chain: A: PDB Molecule:protein jumonji; PDBTitle: solution structure of the at-rich interaction domain (arid)2 of jumonji/jarid2 Phyre2 1 d2o57a1 2 c5gm2E_ 3 c5wp5A_ 4 c4iv0B_ 5 c2fk8A_ 6 d1tpya_ 7 d1kpga_ 8 c3busB_ 9 d2fk8a1 10 d1l1ea_ 11 c4krhB_ 12 d1kpia_ 13 c4ineB_ 14 c5z9oA_ 15 c3ujcA_ 16 c4pneA_ 17 c6bqcA_ 18 d1nkva_ 19 d1q08a_ 20 c2rq5A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99