1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	A	I	G	G	V	I	G	A	G	L	F	V	G	S	G	V	V	I	R	A	T	G	P	A	A	F	L	T	Y	A	L	C	G	A	L	I	V	L	V	M	R	M	L	G	E	M	A	A	A	N	P	S	T	G	A	F	A	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Y	A	A	K	A	L	G	G	W	A	G	F	S	V	G	W	L	Y	W	Y	F	W	V	I	V	V	G	F	E	A	V	A	G	G	K	V	L	T	Y	W	I	D	A	P	L	W	L	A	S	L	C	L	M	M	M	M	T	A	T	N
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	V	S	V	S	S	F	G	E	F	E	F	W	F	A	G	V	K	V	A	T	I	V	G	F	L	V	L	G	T	A	F	A	F	G	L	L	P	G	H	G	M	D	F	S	N	L	S	A	H	G	G	F	F	P	D	G	V	G	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	F	A	A	I	V	V	A	I	F	S	M	T	G	T	E	V	V	T	I	A	A	A	E	A	P	D	P	Q	R	A	V	Q	R	A	M	S	T	V	V	A	R	I	V	I	F	F	V	G	S	V	F	L	L	T	V	I	L	P	W
Secondary structure
SS confidence
Disorder																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		N	S	L	E	L	G	A	S	P	Y	V	A	A	L	R	H	M	G	I	G	G	A	D	Q	I	M	N	A	V	V	L	T	A	V	L	S	C	L	N	S	G	L	Y	T	A	S	R	M	L	F	V	L	A	A	R	Q	E	A	P	A
Secondary structure
SS confidence
Disorder			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Q	L	V	K	V	N	R	R	G	V	P	T	F	A	I	M	G	S	S	V	V	G	F	L	C	V	I	M	A	W	V	S	P	A	T	V	F	V	F	L	L	N	S	S	G	A	V	I	L	F	V	Y	L	L	I	A	L	S	Q	I
Secondary structure
SS confidence
Disorder																														?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	L	R	R	Q	T	S	G	Q	N	L	G	V	R	M	W	L	F	P	G	L	S	I	V	T	V	T	G	I	V	A	V	L	A	R	M	A	F	D	Y	A	A	R	S	Q	L	W	L	S	L	L	S	W	A	V	V	V	G	C	Y
Secondary structure
SS confidence
Disorder								?	?	?																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.
Sequence		L	V	T	T	L	V	R	R	P	L	N	R	P	W
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 5%) Alpha helix ( 77%) Beta strand ( 0%) TM helix ( 60%) (View membrane topology prediction)

Rank Aligned region

PDB 4dji chain A Region: 2 - 434 Aligned: 423 Modelled: 433 Confidence: 100.0% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:probable glutamate/gamma-aminobutyrate antiporter; PDBTitle: structure of glutamate-gaba antiporter gadc Phyre2 PDB 6f2w chain A Region: 2 - 431 Aligned: 413 Modelled: 413 Confidence: 100.0% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:putative amino acid/polyamine transport protein; PDBTitle: bacterial asc transporter crystal structure in open to in conformation Phyre2 PDB 5oqt chain A Region: 1 - 431 Aligned: 408 Modelled: 431 Confidence: 100.0% Identity: 18% PDB header:transport protein Chain: A: PDB Molecule:amino acid transporter; PDBTitle: crystal structure of a bacterial cationic amino acid transporter (cat)2 homologue Phyre2 PDB 6irt chain B Region: 1 - 433 Aligned: 421 Modelled: 421 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: B: PDB Molecule:large neutral amino acids transporter small subunit 1; PDBTitle: human lat1-4f2hc complex bound with bch Phyre2 PDB 3gia chain A Region: 2 - 433 Aligned: 408 Modelled: 408 Confidence: 100.0% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:uncharacterized protein mj0609; PDBTitle: crystal structure of apct transporter Phyre2 PDB 3lrc chain C Region: 1 - 433 Aligned: 393 Modelled: 393 Confidence: 100.0% Identity: 19% PDB header:transport protein Chain: C: PDB Molecule:arginine/agmatine antiporter; PDBTitle: structure of e. coli adic (p1) Phyre2 PDB 6jmq chain A Region: 1 - 425 Aligned: 392 Modelled: 403 Confidence: 100.0% Identity: 17% PDB header:membrane protein/immune system Chain: A: PDB Molecule:large neutral amino acids transporter small subunit 1; PDBTitle: lat1-cd98hc complex bound to mem-108 fab Phyre2 PDB 6csf chain C Region: 1 - 372 Aligned: 359 Modelled: 359 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: C: PDB Molecule:sodium/alanine symporter agcs; PDBTitle: crystal structure of sodium/alanine symporter agcs with d-alanine2 bound Phyre2 PDB 2jln chain A Region: 1 - 434 Aligned: 422 Modelled: 434 Confidence: 100.0% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter Phyre2 PDB 6c08 chain F Region: 4 - 398 Aligned: 365 Modelled: 365 Confidence: 99.7% Identity: 11% PDB header:membrane protein Chain: F: PDB Molecule:sodium-coupled neutral amino acid transporter 9; PDBTitle: zebrafish slc38a9 with arginine bound in the cytosol open state Phyre2 PDB 5nva chain A Region: 4 - 431 Aligned: 405 Modelled: 405 Confidence: 99.5% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:putative sodium:solute symporter; PDBTitle: substrate-bound outward-open state of a na+-coupled sialic acid2 symporter reveals a novel na+-site Phyre2 PDB 6c08 chain C Region: 4 - 393 Aligned: 355 Modelled: 355 Confidence: 99.2% Identity: 11% PDB header:membrane protein Chain: C: PDB Molecule:sodium-coupled neutral amino acid transporter 9; PDBTitle: zebrafish slc38a9 with arginine bound in the cytosol open state Phyre2 PDB 2xq2 chain A Region: 4 - 433 Aligned: 414 Modelled: 414 Confidence: 99.2% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt Phyre2 PDB 4wgw chain A Region: 8 - 392 Aligned: 374 Modelled: 374 Confidence: 99.0% Identity: 8% PDB header:transport protein Chain: A: PDB Molecule:divalent metal cation transporter mnth; PDBTitle: staphylococcus capitis divalent metal ion transporter (dmt) in complex2 with manganese Phyre2 PDB 4wgv chain C Region: 8 - 392 Aligned: 374 Modelled: 374 Confidence: 99.0% Identity: 8% PDB header:transport protein Chain: C: PDB Molecule:divalent metal cation transporter mnth; PDBTitle: crystal structure of staphylococcus capitis divalent metal ion2 transporter (dmt) in complex with nanobody Phyre2 PDB 3dh4 chain A Region: 4 - 434 Aligned: 415 Modelled: 415 Confidence: 99.0% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus Phyre2 PDB 5m87 chain A Region: 2 - 430 Aligned: 423 Modelled: 423 Confidence: 98.2% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:divalent metal cation transporter mnth; PDBTitle: crystal structure of eremococcus coleocola manganese transporter Phyre2 PDB 5i6x chain A Region: 3 - 431 Aligned: 418 Modelled: 418 Confidence: 97.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:sodium-dependent serotonin transporter; PDBTitle: x-ray structure of the ts3 human serotonin transporter complexed with2 paroxetine at the central site Phyre2 PDB 2a65 chain A domain 1 Region: 3 - 432 Aligned: 422 Modelled: 430 Confidence: 96.4% Identity: 12% Fold: SNF-like Superfamily: SNF-like Family: SNF-like Phyre2 PDB 4ain chain B Region: 26 - 375 Aligned: 341 Modelled: 341 Confidence: 96.2% Identity: 9% PDB header:membrane protein Chain: B: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of betp with asymmetric protomers. Phyre2 1 c4djiA_ 2 c6f2wA_ 3 c5oqtA_ 4 c6irtB_ 5 c3giaA_ 6 c3lrcC_ 7 c6jmqA_ 8 c6csfC_ 9 c2jlnA_ 10 c6c08F_ 11 c5nvaA_ 12 c6c08C_ 13 c2xq2A_ 14 c4wgwA_ 15 c4wgvC_ 16 c3dh4A_ 17 c5m87A_ 18 c5i6xA_ 19 d2a65a1 20 c4ainB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87