1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	G	F	T	E	I	A	A	V	G	P	L	L	V	A	V	G	V	C	L	L	A	G	L	V	S	F	A	S	P	C	V	V	P	L	V	P	G	Y	L	S	Y	L	A	A	V	V	G	V	D	E	Q	L	P	A	G	V	V	K
Secondary structure
SS confidence
Disorder		?	?	?				?	?	?	?	?	?																																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	P	V	A	A	R	W	R	V	A	G	S	A	A	L	F	V	A	G	F	T	T	V	F	V	L	G	T	V	A	V	L	G	M	T	T	T	L	I	T	N	Q	L	L	L	Q	R	V	G	G	V	L	I	V	V	M	G	L	V	F
Secondary structure
SS confidence
Disorder		?	?	?																																				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	G	F	I	G	A	L	Q	R	Q	A	R	F	T	P	R	Q	L	T	S	V	A	G	A	P	V	L	G	A	V	F	A	L	G	W	T	P	C	L	G	P	T	L	T	G	V	I	T	V	A	S	A	T	E	G	A	S	V	A	R
Secondary structure
SS confidence
Disorder			?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																														?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	I	V	L	V	I	A	Y	C	L	G	L	G	I	P	F	V	L	L	A	F	G	S	A	W	A	V	A	G	L	G	W	L	R	R	H	T	R	A	I	Q	I	F	G	G	A	L	L	I	A	V	G	A	A	L	V	T	G	V	W
Secondary structure
SS confidence
Disorder																																?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.
Sequence		N	D	V	V	S	W	L	R	D	A	F	V	S	D	V	R	L	P	I
Secondary structure
SS confidence
Disorder																?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 25%) Alpha helix ( 87%) Beta strand ( 0%) TM helix ( 60%) (View membrane topology prediction)

Rank Aligned region

PDB 5vkv chain A Region: 15 - 259 Aligned: 220 Modelled: 227 Confidence: 100.0% Identity: 34% PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome c-type biogenesis protein ccda; PDBTitle: solution nmr structure of the membrane electron transporter ccda Phyre2 PDB 2n4x chain A Region: 19 - 240 Aligned: 186 Modelled: 194 Confidence: 100.0% Identity: 18% PDB header:membrane protein Chain: A: PDB Molecule:cytochrome c-type biogenesis protein (ccda); PDBTitle: structure of the transmembrane electron transporter ccda Phyre2 PDB 5njg chain B Region: 60 - 258 Aligned: 195 Modelled: 199 Confidence: 20.3% Identity: 10% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 2; PDBTitle: structure of an abc transporter: part of the structure that could be2 built de novo Phyre2 PDB 4zjv chain D Region: 30 - 37 Aligned: 8 Modelled: 8 Confidence: 15.0% Identity: 50% PDB header:transferase/inhibitor Chain: D: PDB Molecule:erbb receptor feedback inhibitor 1; PDBTitle: crystal structure of egfr kinase domain in complex with mitogen-2 inducible gene 6 protein Phyre2 PDB 1v54 chain L Region: 182 - 199 Aligned: 18 Modelled: 18 Confidence: 13.6% Identity: 17% Fold: Single transmembrane helix Superfamily: Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) Family: Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa) Phyre2 PDB 2y69 chain Y Region: 182 - 199 Aligned: 18 Modelled: 18 Confidence: 10.8% Identity: 17% PDB header:electron transport Chain: Y: PDB Molecule:cytochrome c oxidase subunit 7c; PDBTitle: bovine heart cytochrome c oxidase re-refined with molecular oxygen Phyre2 PDB 5do7 chain B Region: 47 - 258 Aligned: 208 Modelled: 212 Confidence: 9.5% Identity: 10% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 8; PDBTitle: crystal structure of the human sterol transporter abcg5/abcg8 Phyre2 PDB 1xyr chain 6 Region: 30 - 35 Aligned: 6 Modelled: 6 Confidence: 9.2% Identity: 67% PDB header:virus Chain: 6: PDB Molecule:genome polyprotein, coat protein vp3; PDB Fragment:residues 620-630 PDBTitle: poliovirus 135s cell entry intermediate Phyre2 PDB 6mjp chain F Region: 25 - 138 Aligned: 94 Modelled: 94 Confidence: 7.5% Identity: 10% PDB header:lipid transport Chain: F: PDB Molecule:fig000988: predicted permease; PDBTitle: lptb(e163q)fgc from vibrio cholerae Phyre2 PDB 4p79 chain A Region: 177 - 251 Aligned: 75 Modelled: 75 Confidence: 6.4% Identity: 17% PDB header:cell adhesion Chain: A: PDB Molecule:claudin-15; PDBTitle: crystal structure of mouse claudin-15 Phyre2 PDB 2hg5 chain D Region: 222 - 249 Aligned: 28 Modelled: 28 Confidence: 6.2% Identity: 11% PDB header:membrane protein Chain: D: PDB Molecule:kcsa channel; PDBTitle: cs+ complex of a k channel with an amide to ester substitution in the2 selectivity filter Phyre2 PDB 1eak chain A domain 5 Region: 30 - 35 Aligned: 6 Modelled: 6 Confidence: 5.1% Identity: 67% Fold: Kringle-like Superfamily: Kringle-like Family: Fibronectin type II module Phyre2 1 c5vkvA_ 2 c2n4xA_ 3 c5njgB_ 4 c4zjvD_ 5 d1v54l_ 6 c2y69Y_ 7 c5do7B_ 8 c1xyr6_ 9 c6mjpF_ 10 c4p79A_ 11 c2hg5D_ 12 d1eaka5