1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	W	R	S	L	T	S	M	G	T	A	L	V	L	L	F	L	L	A	L	A	A	I	P	G	A	L	L	P	Q	R	G	L	N	A	A	K	V	D	D	Y	L	A	A	H	P	L	I	G	P	W	L	D	E	L	Q	A	F	D	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	S	S	F	W	F	T	A	I	Y	V	L	L	F	V	S	L	V	G	C	L	A	P	R	T	I	E	H	A	R	S	L	R	A	T	P	V	A	A	P	R	N	L	A	R	L	P	K	H	A	H	A	R	L	A	G	E	P	A	A
Secondary structure
SS confidence
Disorder																																			?	?	?	?	?	?	?	?	?			?	?	?		?	?	?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	A	A	T	I	T	G	R	L	R	G	W	R	S	I	T	R	Q	Q	G	D	S	V	E	V	S	A	E	K	G	Y	L	R	E	F	G	N	L	V	F	H	F	A	L	L	G	L	L	V	A	V	A	V	G	K	L	F	G	Y	E
Secondary structure
SS confidence
Disorder																				?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	N	V	I	V	I	A	D	G	G	P	G	F	C	S	A	S	P	A	A	F	D	S	F	R	A	G	N	T	V	D	G	T	S	L	H	P	I	C	V	R	V	N	N	F	Q	A	H	Y	L	P	S	G	Q	A	T	S	F	A	A
Secondary structure
SS confidence
Disorder											?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																	?					?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		D	I	D	Y	Q	A	D	P	A	T	A	D	L	I	A	N	S	W	R	P	Y	R	L	Q	V	N	H	P	L	R	V	G	G	D	R	V	Y	L	Q	G	H	G	Y	A	P	T	F	T	V	T	F	P	D	G	Q	T	R	T	S	T
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?	?	?	?	?	?	?																								?		?							?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	Q	W	R	P	D	N	P	Q	T	L	L	S	A	G	V	V	R	I	D	P	P	A	G	S	Y	P	N	P	D	E	R	R	K	H	Q	I	A	I	Q	G	L	L	A	P	T	E	Q	L	D	G	T	L	L	S	S	R	F	P	A
Secondary structure
SS confidence
Disorder		?		?		?	?	?	?	?	?	?												?	?	?	?	?	?	?	?	?	?	?	?																?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	N	A	P	A	V	A	I	D	I	Y	R	G	D	T	G	L	D	S	G	R	P	Q	S	L	F	T	L	D	H	R	L	I	E	Q	G	R	L	V	K	E	K	R	V	N	L	R	A	G	Q	Q	V	R	I	D	Q	G	P	A	A
Secondary structure
SS confidence
Disorder		?		?									?	?	?	?	?	?	?	?	?										?	?	?	?	?	?	?	?	?	?	?	?	?								?					?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		G	T	V	V	R	F	D	G	A	V	P	F	V	N	L	Q	V	S	H	D	P	G	Q	S	W	V	L	V	F	A	I	T	M	M	A	G	L	L	V	S	L	L	V	R	R	R	R	V	W	A	R	I	T	P	T	T	A	G	T	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.
Sequence		N	V	E	L	G	G	L	T	R	T	D	N	S	G	W	G	A	E	F	E	R	L	T	G	R	L	L	A	G	F	E	A	R	S	P	D	M	A	E	A	A	A	G	T	G	R	D	V	D
Secondary structure
SS confidence
Disorder												?	?	?															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 30%) Alpha helix ( 27%) Beta strand ( 29%) TM helix ( 15%) (View membrane topology prediction)

Rank Aligned region

PDB 1y5i chain C domain 1 Region: 151 - 174 Aligned: 24 Modelled: 24 Confidence: 68.9% Identity: 25% Fold: Heme-binding four-helical bundle Superfamily: Respiratory nitrate reductase 1 gamma chain Family: Respiratory nitrate reductase 1 gamma chain Phyre2 PDB 5lm4 chain A Region: 1 - 81 Aligned: 68 Modelled: 81 Confidence: 63.7% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:excitatory amino acid transporter 1,neutral amino acid PDBTitle: structure of the thermostalilized eaat1 cryst-ii mutant in complex2 with l-asp and the allosteric inhibitor ucph101 Phyre2 PDB 1wjw chain A Region: 469 - 520 Aligned: 52 Modelled: 52 Confidence: 42.0% Identity: 19% Fold: TBP-like Superfamily: Phosphoglucomutase, C-terminal domain Family: Phosphoglucomutase, C-terminal domain Phyre2 PDB 6oce chain B Region: 4 - 94 Aligned: 85 Modelled: 86 Confidence: 28.2% Identity: 15% PDB header:transport protein Chain: B: PDB Molecule:stress-gated cation channel 1.2; PDBTitle: structure of the rice hyperosmolality-gated ion channel osca1.2 Phyre2 PDB 2k21 chain A Region: 443 - 467 Aligned: 24 Modelled: 25 Confidence: 18.0% Identity: 25% PDB header:membrane protein Chain: A: PDB Molecule:potassium voltage-gated channel subfamily e PDBTitle: nmr structure of human kcne1 in lmpg micelles at ph 6.0 and2 40 degree c Phyre2 PDB 2ndj chain A Region: 443 - 467 Aligned: 24 Modelled: 25 Confidence: 15.8% Identity: 17% PDB header:membrane protein Chain: A: PDB Molecule:potassium voltage-gated channel subfamily e member 3; PDBTitle: structural basis for kcne3 and estrogen modulation of the kcnq12 channel Phyre2 PDB 2k9y chain A Region: 446 - 467 Aligned: 22 Modelled: 22 Confidence: 15.6% Identity: 27% PDB header:transferase Chain: A: PDB Molecule:ephrin type-a receptor 2; PDBTitle: epha2 dimeric structure in the lipidic bicelle at ph 5.0 Phyre2 PDB 2k9y chain B Region: 446 - 467 Aligned: 22 Modelled: 22 Confidence: 15.6% Identity: 27% PDB header:transferase Chain: B: PDB Molecule:ephrin type-a receptor 2; PDBTitle: epha2 dimeric structure in the lipidic bicelle at ph 5.0 Phyre2 PDB 1f20 chain A Region: 355 - 505 Aligned: 126 Modelled: 128 Confidence: 15.3% Identity: 12% PDB header:oxidoreductase Chain: A: PDB Molecule:nitric-oxide synthase; PDBTitle: crystal structure of rat neuronal nitric-oxide synthase fad/nadp+2 domain at 1.9a resolution. Phyre2 PDB 1bhb chain A Region: 436 - 458 Aligned: 23 Modelled: 23 Confidence: 12.4% Identity: 26% PDB header:photoreceptor Chain: A: PDB Molecule:bacteriorhodopsin; PDBTitle: three-dimensional structure of (1-71) bacterioopsin2 solubilized in methanol-chloroform and sds micelles3 determined by 15n-1h heteronuclear nmr spectroscopy Phyre2 PDB 5och chain F Region: 1 - 93 Aligned: 78 Modelled: 88 Confidence: 11.8% Identity: 22% PDB header:hydrolase Chain: F: PDB Molecule:atp-binding cassette sub-family b member 8, mitochondrial; PDBTitle: the crystal structure of human abcb8 in an outward-facing state Phyre2 PDB 2m0q chain A Region: 443 - 467 Aligned: 24 Modelled: 25 Confidence: 11.5% Identity: 21% PDB header:membrane protein Chain: A: PDB Molecule:potassium voltage-gated channel subfamily e member 2; PDBTitle: solution nmr analysis of intact kcne2 in detergent micelles2 demonstrate a straight transmembrane helix Phyre2 PDB 6nd1 chain E Region: 443 - 466 Aligned: 24 Modelled: 24 Confidence: 11.3% Identity: 13% PDB header:protein transport Chain: E: PDB Molecule:translocation protein sec66; PDBTitle: cryoem structure of the sec complex from yeast Phyre2 PDB 5ws4 chain A Region: 15 - 96 Aligned: 66 Modelled: 66 Confidence: 11.0% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:macrolide export atp-binding/permease protein macb; PDBTitle: crystal structure of tripartite-type abc transporter macb from2 acinetobacter baumannii Phyre2 PDB 2klu chain A Region: 448 - 466 Aligned: 19 Modelled: 19 Confidence: 10.4% Identity: 32% PDB header:immune system, membrane protein Chain: A: PDB Molecule:t-cell surface glycoprotein cd4; PDBTitle: nmr structure of the transmembrane and cytoplasmic domains2 of human cd4 Phyre2 PDB 2ks1 chain B Region: 451 - 468 Aligned: 18 Modelled: 18 Confidence: 9.9% Identity: 28% PDB header:transferase Chain: B: PDB Molecule:epidermal growth factor receptor; PDBTitle: heterodimeric association of transmembrane domains of erbb1 and erbb22 receptors enabling kinase activation Phyre2 PDB 5a43 chain B Region: 15 - 82 Aligned: 43 Modelled: 47 Confidence: 9.5% Identity: 33% PDB header:transport protein Chain: B: PDB Molecule:putative fluoride ion transporter crcb; PDBTitle: crystal structure of a dual topology fluoride ion channel. Phyre2 PDB 2m1j chain A Region: 63 - 84 Aligned: 22 Modelled: 22 Confidence: 9.4% Identity: 23% PDB header:unknown function Chain: A: PDB Molecule:prion-like protein doppel; PDBTitle: ovine doppel signal peptide (1-30) Phyre2 PDB 5gas chain N Region: 152 - 179 Aligned: 28 Modelled: 28 Confidence: 8.8% Identity: 14% PDB header:hydrolase Chain: N: PDB Molecule:archaeal/vacuolar-type h+-atpase subunit i; PDBTitle: thermus thermophilus v/a-atpase, conformation 2 Phyre2 PDB 6adq chain P Region: 445 - 471 Aligned: 27 Modelled: 27 Confidence: 8.3% Identity: 30% PDB header:electron transport Chain: P: PDB Molecule:prokaryotic respiratory supercomplex associate factor 1 PDBTitle: respiratory complex ciii2civ2sod2 from mycobacterium smegmatis Phyre2 1 d1y5ic1 2 c5lm4A_ 3 d1wjwa_ 4 c6oceB_ 5 c2k21A_ 6 c2ndjA_ 7 c2k9yA_ 8 c2k9yB_ 9 c1f20A_ 10 c1bhbA_ 11 c5ochF_ 12 c2m0qA_ 13 c6nd1E_ 14 c5ws4A_ 15 c2kluA_ 16 c2ks1B_ 17 c5a43B_ 18 c2m1jA_ 19 c5gasN_ 20 c6adqP_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68