1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	E	A	P	N	D	K	T	T	R	G	V	V	D	I	L	V	Y	A	T	A	R	L	L	L	V	V	A	V	S	A	A	I	F	G	V	A	R	L	I	G	L	T	E	F	P	V	V	V	A	T	L	F	G	L	I	I	A	M
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.
Sequence		P	L	G	I	W	V	F	S	P	L	R	R	R	A	T	A	A	L	A	V	A	G	E	R	R	R	A	E	R	E	R	L	R	A	R	L	R	G	E	S	L	P	E	E	Q
Secondary structure
SS confidence
Disorder										?																											?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 20%) Alpha helix ( 76%) Beta strand ( 0%) TM helix ( 47%) (View membrane topology prediction)

Rank Aligned region

PDB 2k1k chain A Region: 49 - 71 Aligned: 23 Modelled: 23 Confidence: 44.8% Identity: 52% PDB header:signaling protein Chain: A: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 4.3 Phyre2 PDB 2k1k chain B Region: 49 - 71 Aligned: 23 Modelled: 23 Confidence: 44.8% Identity: 52% PDB header:signaling protein Chain: B: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 4.3 Phyre2 PDB 2k1l chain B Region: 49 - 71 Aligned: 23 Modelled: 23 Confidence: 44.8% Identity: 52% PDB header:signaling protein Chain: B: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 6.3 Phyre2 PDB 2k1l chain A Region: 49 - 71 Aligned: 23 Modelled: 23 Confidence: 44.8% Identity: 52% PDB header:signaling protein Chain: A: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 6.3 Phyre2 PDB 2mic chain A Region: 46 - 71 Aligned: 25 Modelled: 26 Confidence: 26.9% Identity: 16% PDB header:membrane protein Chain: A: PDB Molecule:tumor necrosis factor receptor superfamily member 16; PDBTitle: nmr structure of p75 transmembrane domain in dpc micelles Phyre2 PDB 2mic chain B Region: 46 - 71 Aligned: 25 Modelled: 26 Confidence: 26.9% Identity: 16% PDB header:membrane protein Chain: B: PDB Molecule:tumor necrosis factor receptor superfamily member 16; PDBTitle: nmr structure of p75 transmembrane domain in dpc micelles Phyre2 PDB 2kb1 chain A Region: 41 - 88 Aligned: 48 Modelled: 48 Confidence: 25.5% Identity: 23% PDB header:membrane protein Chain: A: PDB Molecule:wsk3; PDBTitle: nmr studies of a channel protein without membrane:2 structure and dynamics of water-solubilized kcsa Phyre2 PDB 1r3j chain C Region: 41 - 88 Aligned: 48 Modelled: 48 Confidence: 23.0% Identity: 19% Fold: Voltage-gated potassium channels Superfamily: Voltage-gated potassium channels Family: Voltage-gated potassium channels Phyre2 PDB 4wd7 chain A Region: 23 - 87 Aligned: 56 Modelled: 65 Confidence: 20.5% Identity: 34% PDB header:membrane protein Chain: A: PDB Molecule:bestrophin domain protein; PDBTitle: crystal structure of a bacterial bestrophin homolog from klebsiella2 pneumoniae by zn-sad phasing Phyre2 PDB 1cii chain A Region: 49 - 67 Aligned: 19 Modelled: 19 Confidence: 18.4% Identity: 32% PDB header:transmembrane protein Chain: A: PDB Molecule:colicin ia; PDBTitle: colicin ia Phyre2 PDB 2lx0 chain A Region: 49 - 70 Aligned: 22 Modelled: 22 Confidence: 15.7% Identity: 36% PDB header:membrane protein Chain: A: PDB Molecule:membrane fusion protein p14; PDBTitle: arced helix (arch) nmr structure of the reovirus p14 fusion-associated2 small transmembrane (fast) protein transmembrane domain (tmd) in3 dodecyl phosphocholine (dpc) micelles Phyre2 PDB 1pnb chain A Region: 86 - 100 Aligned: 15 Modelled: 15 Confidence: 13.3% Identity: 33% PDB header:seed storage protein Chain: A: PDB Molecule:napin bnib; PDBTitle: structure of napin bnib, nmr, 10 structures Phyre2 PDB 2l1x chain A Region: 87 - 98 Aligned: 12 Modelled: 12 Confidence: 12.8% Identity: 33% PDB header:hormone Chain: A: PDB Molecule:parathyroid hormone; PDBTitle: the solution structure of human parathyroid hormone-related protein Phyre2 PDB 5sv0 chain C Region: 49 - 99 Aligned: 50 Modelled: 51 Confidence: 11.3% Identity: 22% PDB header:transport protein Chain: C: PDB Molecule:biopolymer transport protein exbb; PDBTitle: structure of the exbb/exbd complex from e. coli at ph 7.0 Phyre2 PDB 2i88 chain A Region: 49 - 67 Aligned: 19 Modelled: 19 Confidence: 9.0% Identity: 53% PDB header:membrane protein Chain: A: PDB Molecule:colicin-e1; PDBTitle: crystal structure of the channel-forming domain of colicin e1 Phyre2 PDB 3lfm chain A Region: 76 - 104 Aligned: 28 Modelled: 29 Confidence: 8.7% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:protein fto; PDBTitle: crystal structure of the fat mass and obesity associated (fto) protein2 reveals basis for its substrate specificity Phyre2 PDB 2ib0 chain A domain 1 Region: 74 - 104 Aligned: 31 Modelled: 31 Confidence: 8.0% Identity: 16% Fold: Ferritin-like Superfamily: Ferritin-like Family: Rv2844-like Phyre2 PDB 2ib0 chain A Region: 74 - 104 Aligned: 31 Modelled: 31 Confidence: 8.0% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical alanine rich protein; PDBTitle: crystal structure of a conserved hypothetical protein, rv2844, from2 mycobacterium tuberculosis Phyre2 PDB 2kkt chain A Region: 82 - 92 Aligned: 11 Modelled: 11 Confidence: 7.8% Identity: 36% PDB header:transcription Chain: A: PDB Molecule:ataxin-7-like protein 3; PDBTitle: solution structure of the sca7 domain of human ataxin-7-l3 protein Phyre2 PDB 4g4g chain A Region: 76 - 105 Aligned: 30 Modelled: 30 Confidence: 7.7% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:4-o-methyl-glucuronoyl methylesterase; PDBTitle: crystal structure of recombinant glucuronoyl esterase from2 sporotrichum thermophile determined at 1.55 a resolution Phyre2 1 c2k1kA_ 2 c2k1kB_ 3 c2k1lB_ 4 c2k1lA_ 5 c2micA_ 6 c2micB_ 7 c2kb1A_ 8 d1r3jc_ 9 c4wd7A_ 10 c1ciiA_ 11 c2lx0A_ 12 c1pnbA_ 13 c2l1xA_ 14 c5sv0C_ 15 c2i88A_ 16 c3lfmA_ 17 d2ib0a1 18 c2ib0A_ 19 c2kktA_ 20 c4g4gA_ 21 22 23 24 25 26 27 28 29