1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	S	F	A	Q	W	V	S	G	A	R	P	R	T	L	P	N	A	I	A	P	V	V	A	G	T	G	A	A	A	W	L	H	A	A	V	W	W	K	A	L	L	A	L	A	V	A	V	A	L	V	I	G	V	N	Y	A	N	D
Secondary structure
SS confidence
Disorder		?	?	?										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Y	S	D	G	I	R	G	T	D	D	D	R	V	G	P	V	R	L	V	G	S	R	L	A	T	P	R	S	V	L	T	A	A	M	T	S	L	A	L	G	A	L	A	G	L	V	L	A	L	L	S	A	P	W	L	I	A	V	G	A
Secondary structure
SS confidence
Disorder												?		?					?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	C	I	A	G	A	W	L	Y	T	G	G	S	K	P	Y	G	Y	A	G	F	G	E	L	A	V	F	V	F	F	G	P	V	A	V	L	G	T	Q	Y	T	Q	A	L	R	V	D	W	V	G	L	A	Q	A	V	A	T	G	A	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	C	S	V	L	V	A	N	N	L	R	D	I	P	T	D	A	R	A	D	K	I	T	L	A	V	R	L	G	D	A	R	T	R	M	L	Y	Q	G	L	L	A	V	A	G	V	L	T	F	V	L	M	L	A	T	P	W	C	V	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.
Sequence		G	L	V	A	A	P	L	A	L	R	A	A	G	P	V	R	S	G	R	G	G	R	E	L	I	P	V	L	R	D	T	G	L	A	M	L	V	W	A	L	A	V	A	G	A	L	A	F	G	Q	L	S
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?																												?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 78%) Beta strand ( 0%) TM helix ( 59%) (View membrane topology prediction)

Rank Aligned region

PDB 4od5 chain C Region: 9 - 282 Aligned: 271 Modelled: 274 Confidence: 100.0% Identity: 13% PDB header:transferase Chain: C: PDB Molecule:4-hydroxybenzoate octaprenyltransferase; PDBTitle: substrate-bound structure of a ubia homolog from aeropyrum pernix k1 Phyre2 PDB 3m9u chain D Region: 22 - 217 Aligned: 191 Modelled: 196 Confidence: 95.9% Identity: 12% PDB header:transferase Chain: D: PDB Molecule:farnesyl-diphosphate synthase; PDBTitle: crystal structure of geranylgeranyl pyrophosphate synthase from2 lactobacillus brevis atcc 367 Phyre2 PDB 3ts7 chain B Region: 27 - 221 Aligned: 191 Modelled: 195 Confidence: 95.9% Identity: 10% PDB header:transferase Chain: B: PDB Molecule:geranyltranstransferase; PDBTitle: crystal structure of farnesyl diphosphate synthase (target efi-501951)2 from methylococcus capsulatus Phyre2 PDB 3npk chain B Region: 150 - 229 Aligned: 80 Modelled: 80 Confidence: 84.8% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:geranyltranstransferase; PDBTitle: the crystal structure of geranyltranstransferase from campylobacter2 jejuni Phyre2 PDB 3kra chain B Region: 150 - 228 Aligned: 78 Modelled: 79 Confidence: 82.1% Identity: 13% PDB header:transferase Chain: B: PDB Molecule:geranyl diphosphate synthase small subunit; PDBTitle: mint heterotetrameric geranyl pyrophosphate synthase in complex with2 magnesium Phyre2 PDB 5xn5 chain A Region: 27 - 217 Aligned: 187 Modelled: 191 Confidence: 81.4% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:os07g0580900 protein; PDBTitle: homo-dimer crystal structure of geranylgeranyl diphosphate synthases 12 from oryza sativa Phyre2 PDB 3p8l chain B Region: 150 - 228 Aligned: 79 Modelled: 79 Confidence: 79.0% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:geranyltranstransferase; PDBTitle: crystal structure of polyprenyl synthase from enterococcus faecalis2 v583 Phyre2 PDB 3oac chain D Region: 27 - 217 Aligned: 187 Modelled: 191 Confidence: 73.2% Identity: 13% PDB header:transferase Chain: D: PDB Molecule:geranyl diphosphate synthase large subunit; PDBTitle: mint deletion mutant of heterotetrameric geranyl pyrophosphate2 synthase in complex with ligands Phyre2 PDB 3wjn chain A Region: 27 - 213 Aligned: 179 Modelled: 187 Confidence: 72.6% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:octaprenyl diphosphate synthase; PDBTitle: crystal structure of octaprenyl pyrophosphate synthase from2 escherichia coli with farnesyl s-thiol-pyrophosphate (fspp) Phyre2 PDB 5h9d chain B Region: 22 - 211 Aligned: 182 Modelled: 190 Confidence: 70.8% Identity: 12% PDB header:transferase Chain: B: PDB Molecule:farnesyl pyrophosphate synthetase; PDBTitle: crystal structure of heptaprenyl diphosphate synthase from2 staphylococcus aureus Phyre2 PDB 3ipi chain A Region: 150 - 228 Aligned: 77 Modelled: 79 Confidence: 69.2% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:geranyltranstransferase; PDBTitle: crystal structure of a geranyltranstransferase from the methanosarcina2 mazei Phyre2 PDB 2ftz chain A Region: 150 - 228 Aligned: 77 Modelled: 79 Confidence: 66.1% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:geranyltranstransferase; PDBTitle: crystal structure of geranyltranstransferase (ec 2.5.1.10) (tm0161)2 from thermotoga maritima at 1.90 a resolution Phyre2 PDB 2j1o chain A Region: 148 - 217 Aligned: 66 Modelled: 70 Confidence: 64.7% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:geranylgeranyl pyrophosphate synthetase; PDBTitle: geranylgeranyl diphosphate synthase from sinapis alba Phyre2 PDB 1rqj chain A Region: 27 - 217 Aligned: 187 Modelled: 191 Confidence: 63.3% Identity: 12% Fold: Terpenoid synthases Superfamily: Terpenoid synthases Family: Isoprenyl diphosphate synthases Phyre2 PDB 3ez3 chain A Region: 150 - 230 Aligned: 80 Modelled: 81 Confidence: 59.7% Identity: 15% PDB header:lyase Chain: A: PDB Molecule:farnesyl pyrophosphate synthase, putative; PDBTitle: crystal structure of plasmodium vivax geranylgeranylpyrophosphate2 synthase pvx_092040 with zoledronate and ipp bound Phyre2 PDB 3lsn chain A Region: 27 - 221 Aligned: 190 Modelled: 195 Confidence: 58.7% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:geranyltranstransferase; PDBTitle: crystal structure of putative geranyltranstransferase from pseudomonas2 fluorescens pf-5 complexed with magnesium Phyre2 PDB 3oyr chain B Region: 27 - 213 Aligned: 179 Modelled: 187 Confidence: 58.4% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:trans-isoprenyl diphosphate synthase; PDBTitle: crystal structure of polyprenyl synthase from caulobacter crescentus2 cb15 complexed with calcium and isoprenyl diphosphate Phyre2 PDB 4lfg chain B Region: 24 - 216 Aligned: 188 Modelled: 193 Confidence: 57.0% Identity: 12% PDB header:transferase Chain: B: PDB Molecule:geranylgeranyl diphosphate synthase; PDBTitle: crystal structure of geranylgeranyl diphosphate synthase sub12742 (target efi-509455) from streptococcus uberis 0140j with bound3 magnesium and isopentyl diphosphate, fully liganded complex; Phyre2 PDB 1wy0 chain A Region: 27 - 213 Aligned: 179 Modelled: 181 Confidence: 56.9% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:geranylgeranyl pyrophosphate synthetase; PDBTitle: crystal structure of geranylgeranyl pyrophosphate synthetase from2 pyrococcus horikoshii ot3 Phyre2 PDB 2o1o chain B Region: 150 - 228 Aligned: 78 Modelled: 79 Confidence: 56.3% Identity: 10% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative farnesyl pyrophosphate synthase; PDBTitle: cryptosporidium parvum putative polyprenyl pyrophosphate synthase2 (cgd4_2550) in complex with risedronate. Phyre2 1 c4od5C_ 2 c3m9uD_ 3 c3ts7B_ 4 c3npkB_ 5 c3kraB_ 6 c5xn5A_ 7 c3p8lB_ 8 c3oacD_ 9 c3wjnA_ 10 c5h9dB_ 11 c3ipiA_ 12 c2ftzA_ 13 c2j1oA_ 14 d1rqja_ 15 c3ez3A_ 16 c3lsnA_ 17 c3oyrB_ 18 c4lfgB_ 19 c1wy0A_ 20 c2o1oB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55