1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	C	L	P	V	S	V	L	V	V	A	K	A	P	E	P	G	R	V	K	T	R	L	A	A	A	I	G	D	K	V	A	A	D	I	A	A	A	A	L	L	D	T	L	D	A	V	A	A	A	P	V	T	A	R	A	V	A	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	G	D	L	D	S	A	A	D	S	A	E	I	R	R	R	L	K	S	F	T	V	F	R	Q	R	G	D	A	F	A	D	R	L	A	N	A	H	V	D	A	A	D	G	Y	P	V	L	Q	I	G	M	D	T	P	Q	V	T	A	E
Secondary structure
SS confidence
Disorder																												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	L	A	D	C	A	R	L	L	L	Q	I	P	A	V	L	G	L	A	F	D	G	G	W	W	V	L	G	I	R	T	P	T	A	A	E	C	L	R	A	V	P	M	S	Q	P	D	T	G	E	L	T	L	K	A	L	R	D	N	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220
Sequence		I	D	V	T	L	V	Q	R	L	G	D	F	D	I	V	D	D	I	A	L	V	R	D	C	C	A	P	G	S	R	F	A	Q	A	T	R	A	A	G	L
Secondary structure
SS confidence
Disorder																											?	?					?					?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 41%) Beta strand ( 16%)

Rank Aligned region

PDB 3cgx chain A Region: 5 - 218 Aligned: 212 Modelled: 214 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:putative nucleotide-diphospho-sugar transferase; PDBTitle: crystal structure of putative nucleotide-diphospho-sugar transferase2 (yp_389115.1) from desulfovibrio desulfuricans g20 at 1.90 a3 resolution Phyre2 PDB 2i5e chain A domain 1 Region: 7 - 216 Aligned: 189 Modelled: 210 Confidence: 100.0% Identity: 13% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: MM2497-like Phyre2 PDB 6bwh chain B Region: 5 - 215 Aligned: 202 Modelled: 211 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: B: PDB Molecule:2-phospho-l-lactate guanylyltransferase; PDBTitle: crystal structure of mycoibacterium tuberculosis rv2983 in complex2 with pep Phyre2 PDB 2waw chain A Region: 40 - 205 Aligned: 160 Modelled: 166 Confidence: 98.9% Identity: 14% PDB header:unknown function Chain: A: PDB Molecule:moba relate protein; PDBTitle: crystal structure of mycobacterium tuberculosis rv0371c2 homolog from mycobacterium sp. strain jc1 Phyre2 PDB 3okr chain A Region: 40 - 207 Aligned: 164 Modelled: 168 Confidence: 98.8% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:2-c-methyl-d-erythritol 4-phosphate cytidylyltransferase; PDBTitle: structure of mtb apo 2-c-methyl-d-erythritol 4-phosphate2 cytidyltransferase (ispd) Phyre2 PDB 1e5k chain A Region: 40 - 202 Aligned: 156 Modelled: 163 Confidence: 98.7% Identity: 10% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: Molybdenum cofactor biosynthesis protein MobA Phyre2 PDB 4kt7 chain A Region: 1 - 206 Aligned: 194 Modelled: 205 Confidence: 98.7% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:2-c-methyl-d-erythritol 4-phosphate cytidylyltransferase; PDBTitle: the crystal structure of 4-diphosphocytidyl-2c-methyl-d-2 erythritolsynthase from anaerococcus prevotii dsm 20548 Phyre2 PDB 1w77 chain A domain 1 Region: 40 - 205 Aligned: 165 Modelled: 166 Confidence: 98.7% Identity: 14% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: Cytidylytransferase Phyre2 PDB 1i52 chain A Region: 4 - 206 Aligned: 196 Modelled: 203 Confidence: 98.7% Identity: 18% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: Cytidylytransferase Phyre2 PDB 2vsh chain B Region: 40 - 205 Aligned: 166 Modelled: 165 Confidence: 98.6% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:2-c-methyl-d-erythritol 4-phosphate PDBTitle: synthesis of cdp-activated ribitol for teichoic acid2 precursors in streptococcus pneumoniae Phyre2 PDB 2xwl chain B Region: 40 - 210 Aligned: 168 Modelled: 171 Confidence: 98.6% Identity: 17% PDB header:transferase Chain: B: PDB Molecule:2-c-methyl-d-erythritol 4-phosphate cytidylyltransferase; PDBTitle: crystal structure of ispd from mycobacterium smegmatis in complex with2 ctp and mg Phyre2 PDB 5ddt chain A Region: 4 - 210 Aligned: 202 Modelled: 205 Confidence: 98.6% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:2-c-methyl-d-erythritol 4-phosphate cytidylyltransferase; PDBTitle: crystal structure of ispd from bacillus subtilis at 1.80 angstroms2 resolution, crystal form i Phyre2 PDB 2we9 chain A Region: 40 - 205 Aligned: 159 Modelled: 166 Confidence: 98.5% Identity: 18% PDB header:unknown function Chain: A: PDB Molecule:moba-related protein; PDBTitle: crystal structure of rv0371c from mycobacterium2 tuberculosis h37rv Phyre2 PDB 1vgw chain A Region: 40 - 205 Aligned: 164 Modelled: 164 Confidence: 98.5% Identity: 17% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: Cytidylytransferase Phyre2 PDB 4jis chain B Region: 40 - 204 Aligned: 165 Modelled: 164 Confidence: 98.5% Identity: 12% PDB header:transferase Chain: B: PDB Molecule:ribitol-5-phosphate cytidylyltransferase; PDBTitle: crystal structure of ribitol 5-phosphate cytidylyltransferase (tari)2 from bacillus subtilis Phyre2 PDB 2px7 chain A Region: 4 - 206 Aligned: 178 Modelled: 203 Confidence: 98.5% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:2-c-methyl-d-erythritol 4-phosphate cytidylyltransferase; PDBTitle: crystal structure of 2-c-methyl-d-erythritol 4-phosphate2 cytidylyltransferase from thermus thermophilus hb8 Phyre2 PDB 1w55 chain A domain 1 Region: 40 - 207 Aligned: 160 Modelled: 168 Confidence: 98.5% Identity: 12% Fold: Nucleotide-diphospho-sugar transferases Superfamily: Nucleotide-diphospho-sugar transferases Family: Cytidylytransferase Phyre2 PDB 3okr chain C Region: 40 - 207 Aligned: 157 Modelled: 168 Confidence: 98.5% Identity: 13% PDB header:transferase Chain: C: PDB Molecule:2-c-methyl-d-erythritol 4-phosphate cytidylyltransferase; PDBTitle: structure of mtb apo 2-c-methyl-d-erythritol 4-phosphate2 cytidyltransferase (ispd) Phyre2 PDB 4ys8 chain B Region: 40 - 206 Aligned: 165 Modelled: 167 Confidence: 98.5% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:2-c-methyl-d-erythritol 4-phosphate cytidylyltransferase; PDBTitle: crystal structure of 2-c-methyl-d-erythritol 4-phosphate2 cytidylyltransferase (ispd) from burkholderia thailandensis Phyre2 PDB 4myb chain A Region: 40 - 205 Aligned: 159 Modelled: 165 Confidence: 98.4% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:2-c-methyl-d-erythritol 4-phosphate cytidylyltransferase; PDBTitle: crystal structure of francisella tularensis 2-c-methyl-d-erythritol 4-2 phosphate cytidylyltransferase (ispd) Phyre2 1 c3cgxA_ 2 d2i5ea1 3 c6bwhB_ 4 c2wawA_ 5 c3okrA_ 6 d1e5ka_ 7 c4kt7A_ 8 d1w77a1 9 d1i52a_ 10 c2vshB_ 11 c2xwlB_ 12 c5ddtA_ 13 c2we9A_ 14 d1vgwa_ 15 c4jisB_ 16 c2px7A_ 17 d1w55a1 18 c3okrC_ 19 c4ys8B_ 20 c4mybA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110