1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	N	L	Q	L	F	L	L	L	I	V	V	V	T	A	L	A	F	D	F	T	N	G	F	H	D	T	G	N	A	M	A	T	S	I	A	S	G	A	L	A	P	R	V	A	V	A	L	P	A	V	L	N	L	I	G	A	F	L	S
Secondary structure
SS confidence
Disorder		?	?																																			?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	A	V	A	A	T	I	A	K	G	L	I	D	A	N	L	V	T	L	E	L	V	F	A	G	L	V	G	G	I	V	W	N	L	L	T	W	L	L	G	I	P	S	S	S	S	H	A	L	I	G	G	I	V	G	A	T	I	A	A
Secondary structure
SS confidence
Disorder																		?	?																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	G	L	R	G	V	I	W	S	G	V	V	S	K	V	I	V	P	A	V	V	A	A	L	L	A	T	L	V	G	A	V	G	T	W	L	V	Y	R	T	T	R	G	V	A	E	K	R	T	E	R	G	F	R	R	G	Q	I	G	S
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	S	L	V	S	L	A	H	G	T	N	D	A	Q	K	T	M	G	V	I	F	L	A	L	M	S	Y	G	A	V	S	T	T	A	S	V	P	P	L	W	V	I	V	S	C	A	V	A	M	A	A	G	T	Y	L	G	G	W	R	I
Secondary structure
SS confidence
Disorder													?																			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	R	T	L	G	K	G	L	V	E	I	K	P	P	Q	G	M	A	A	E	S	S	S	A	A	V	I	L	L	S	A	H	F	G	Y	A	L	S	T	T	Q	V	A	T	G	S	V	L	G	S	G	V	G	K	P	G	A	E	V	R
Secondary structure
SS confidence
Disorder												?	?																					?					?															?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		W	G	V	A	G	R	M	V	V	A	W	L	V	T	L	P	L	A	G	L	V	G	A	F	T	Y	G	L	V	H	F	I	G	G	Y	P	G	A	I	L	G	F	A	L	L	W	L	T	A	T	A	I	W	L	R	S	R	R	A	P
Secondary structure
SS confidence
Disorder																																																									?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.
Sequence		I	D	H	T	N	V	N	A	D	W	E	G	N	L	T	A	G	L	E	A	G	A	Q	P	L	A	D	Q	R	P	P	V	P	A	P	P	A	P	T	P	P	P	N	H	R	A	P	Q	F	G	V	T	T	R	N	A	P
Secondary structure
SS confidence
Disorder															?		?	?	?	?	?				?	?	?	?	?	?	?	?	?	?	?	?	?	?		?		?	?	?								?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 74%) Beta strand ( 0%) TM helix ( 55%) (View membrane topology prediction)

Rank Aligned region

PDB 2lnh chain C Region: 382 - 405 Aligned: 24 Modelled: 24 Confidence: 56.6% Identity: 46% PDB header:signaling protein/protein binding Chain: C: PDB Molecule:secreted effector protein espf(u); PDBTitle: enterohaemorrhagic e. coli (ehec) exploits a tryptophan switch to2 hijack host f-actin assembly Phyre2 PDB 2k9p chain A Region: 335 - 361 Aligned: 27 Modelled: 27 Confidence: 42.0% Identity: 41% PDB header:membrane protein Chain: A: PDB Molecule:pheromone alpha factor receptor; PDBTitle: structure of tm1_tm2 in lppg micelles Phyre2 PDB 4kpp chain A Region: 215 - 373 Aligned: 148 Modelled: 159 Confidence: 42.0% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of h+/ca2+ exchanger cax Phyre2 PDB 3t5x chain B Region: 362 - 379 Aligned: 18 Modelled: 18 Confidence: 41.8% Identity: 44% PDB header:transcription Chain: B: PDB Molecule:26s proteasome complex subunit dss1; PDBTitle: pcid2:dss1 structure Phyre2 PDB 2w2e chain A Region: 9 - 167 Aligned: 158 Modelled: 159 Confidence: 35.0% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:aquaporin pip2-7 7; PDBTitle: 1.15 angstrom crystal structure of p.pastoris aquaporin, aqy1, in a2 closed conformation at ph 3.5 Phyre2 PDB 5gjq chain Y Region: 359 - 380 Aligned: 22 Modelled: 22 Confidence: 32.9% Identity: 36% PDB header:hydrolase Chain: Y: PDB Molecule:26s proteasome complex subunit dss1; PDBTitle: structure of the human 26s proteasome bound to usp14-ubal Phyre2 PDB 1j4n chain A Region: 3 - 172 Aligned: 168 Modelled: 170 Confidence: 29.0% Identity: 14% Fold: Aquaporin-like Superfamily: Aquaporin-like Family: Aquaporin-like Phyre2 PDB 3eh4 chain A Region: 109 - 244 Aligned: 136 Modelled: 136 Confidence: 25.9% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome c oxidase subunit 1; PDBTitle: structure of the reduced form of cytochrome ba3 oxidase from thermus2 thermophilus Phyre2 PDB 6gcs chain H Region: 366 - 400 Aligned: 35 Modelled: 35 Confidence: 22.8% Identity: 17% PDB header:oxidoreductase Chain: H: PDB Molecule:24-kda subunit (nuhm); PDBTitle: cryo-em structure of respiratory complex i from yarrowia lipolytica Phyre2 PDB 1h6i chain A Region: 6 - 157 Aligned: 150 Modelled: 152 Confidence: 20.5% Identity: 15% Fold: Aquaporin-like Superfamily: Aquaporin-like Family: Aquaporin-like Phyre2 PDB 6m97 chain A Region: 193 - 239 Aligned: 37 Modelled: 47 Confidence: 19.8% Identity: 27% PDB header:transport protein Chain: A: PDB Molecule:chimera protein of high affinity copper uptake protein 1 PDBTitle: crystal structure of the high-affinity copper transporter ctr1 Phyre2 PDB 1iyj chain C Region: 362 - 379 Aligned: 18 Modelled: 18 Confidence: 18.0% Identity: 44% PDB header:gene regulation/antitumor protein Chain: C: PDB Molecule:deleted in split hand/split foot protein 1; PDBTitle: structure of a brca2-dss1 complex Phyre2 PDB 1xme chain A domain 1 Region: 109 - 244 Aligned: 136 Modelled: 136 Confidence: 17.2% Identity: 14% Fold: Cytochrome c oxidase subunit I-like Superfamily: Cytochrome c oxidase subunit I-like Family: Cytochrome c oxidase subunit I-like Phyre2 PDB 2qlv chain A domain 1 Region: 379 - 417 Aligned: 36 Modelled: 39 Confidence: 16.3% Identity: 22% Fold: TBP-like Superfamily: KA1-like Family: Ssp2 C-terminal domain-like Phyre2 PDB 2knc chain A Region: 208 - 228 Aligned: 21 Modelled: 21 Confidence: 15.4% Identity: 19% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 2ia2 chain D Region: 268 - 297 Aligned: 30 Modelled: 30 Confidence: 13.9% Identity: 7% PDB header:transcription Chain: D: PDB Molecule:putative transcriptional regulator; PDBTitle: the crystal structure of a putative transcriptional regulator rha061952 from rhodococcus sp. rha1 Phyre2 PDB 2b6p chain A Region: 3 - 171 Aligned: 168 Modelled: 169 Confidence: 13.7% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:lens fiber major intrinsic protein; PDBTitle: x-ray structure of lens aquaporin-0 (aqp0) (lens mip) in an open pore2 state Phyre2 PDB 1f2r chain I Region: 385 - 415 Aligned: 31 Modelled: 31 Confidence: 13.1% Identity: 26% Fold: beta-Grasp (ubiquitin-like) Superfamily: CAD & PB1 domains Family: CAD domain Phyre2 PDB 2m59 chain A Region: 1 - 18 Aligned: 18 Modelled: 18 Confidence: 13.1% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:vascular endothelial growth factor receptor 2; PDBTitle: spatial structure of dimeric vegfr2 membrane domain in dpc micelles Phyre2 PDB 2m59 chain B Region: 1 - 18 Aligned: 18 Modelled: 18 Confidence: 13.1% Identity: 33% PDB header:transferase Chain: B: PDB Molecule:vascular endothelial growth factor receptor 2; PDBTitle: spatial structure of dimeric vegfr2 membrane domain in dpc micelles Phyre2 1 c2lnhC_ 2 c2k9pA_ 3 c4kppA_ 4 c3t5xB_ 5 c2w2eA_ 6 c5gjqY_ 7 d1j4na_ 8 c3eh4A_ 9 c6gcsH_ 10 d1h6ia_ 11 c6m97A_ 12 c1iyjC_ 13 d1xmea1 14 d2qlva1 15 c2kncA_ 16 c2ia2D_ 17 c2b6pA_ 18 d1f2ri_ 19 c2m59A_ 20 c2m59B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99