1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	G	T	K	L	A	V	V	V	G	M	T	V	A	A	V	S	L	A	A	P	A	Q	A	D	D	Y	D	A	P	F	N	N	T	I	H	R	F	G	I	Y	G	P	Q	D	Y	N	A	W	L	A	K	I	S	C	E	R	L	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?										?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.
Sequence		R	G	V	D	G	D	A	Y	K	S	A	T	F	L	Q	R	N	L	P	R	G	T	T	Q	G	Q	A	F	Q	F	L	G	A	A	I	D	H	Y	C	P	E	H	V	G	V	L	Q	R	A	G	T	R
Secondary structure
SS confidence
Disorder			?	?																	?	?	?	?	?																									?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 24%) Alpha helix ( 65%) Beta strand ( 6%)

Rank Aligned region

PDB 3ism chain C Region: 40 - 63 Aligned: 24 Modelled: 24 Confidence: 90.7% Identity: 42% PDB header:hydrolase inhibitor/hydrolase Chain: C: PDB Molecule:cg4930; PDBTitle: crystal structure of the endog/endogi complex: mechanism of endog2 inhibition Phyre2 PDB 6nhw chain A Region: 1 - 19 Aligned: 19 Modelled: 19 Confidence: 28.6% Identity: 47% PDB header:immune system Chain: A: PDB Molecule:tumor necrosis factor receptor superfamily member 10b; PDBTitle: structure of the transmembrane domain of the death receptor 5 - dimer2 of trimer Phyre2 PDB 6nhw chain B Region: 1 - 19 Aligned: 19 Modelled: 19 Confidence: 28.5% Identity: 47% PDB header:immune system Chain: B: PDB Molecule:tumor necrosis factor receptor superfamily member 10b; PDBTitle: structure of the transmembrane domain of the death receptor 5 - dimer2 of trimer Phyre2 PDB 6nhw chain C Region: 1 - 19 Aligned: 19 Modelled: 19 Confidence: 27.5% Identity: 47% PDB header:immune system Chain: C: PDB Molecule:tumor necrosis factor receptor superfamily member 10b; PDBTitle: structure of the transmembrane domain of the death receptor 5 - dimer2 of trimer Phyre2 PDB 6nhw chain D Region: 1 - 19 Aligned: 19 Modelled: 19 Confidence: 26.7% Identity: 47% PDB header:immune system Chain: D: PDB Molecule:tumor necrosis factor receptor superfamily member 10b; PDBTitle: structure of the transmembrane domain of the death receptor 5 - dimer2 of trimer Phyre2 PDB 6nhw chain F Region: 1 - 19 Aligned: 19 Modelled: 19 Confidence: 26.6% Identity: 47% PDB header:immune system Chain: F: PDB Molecule:tumor necrosis factor receptor superfamily member 10b; PDBTitle: structure of the transmembrane domain of the death receptor 5 - dimer2 of trimer Phyre2 PDB 6nhw chain E Region: 1 - 19 Aligned: 19 Modelled: 19 Confidence: 26.6% Identity: 47% PDB header:immune system Chain: E: PDB Molecule:tumor necrosis factor receptor superfamily member 10b; PDBTitle: structure of the transmembrane domain of the death receptor 5 - dimer2 of trimer Phyre2 PDB 1mg7 chain A domain 1 Region: 38 - 55 Aligned: 18 Modelled: 18 Confidence: 23.3% Identity: 33% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: Early switch protein XOL-1, N-terminal domain Phyre2 PDB 1mg7 chain B Region: 38 - 55 Aligned: 18 Modelled: 18 Confidence: 20.5% Identity: 33% PDB header:gene regulation Chain: B: PDB Molecule:early switch protein xol-1 2.2k splice form; PDBTitle: crystal structure of xol-1 Phyre2 PDB 2euc chain A domain 1 Region: 45 - 51 Aligned: 7 Modelled: 7 Confidence: 19.4% Identity: 71% Fold: YfmB-like Superfamily: YfmB-like Family: YfmB-like Phyre2 PDB 6c3r chain B Region: 85 - 103 Aligned: 15 Modelled: 19 Confidence: 18.1% Identity: 47% PDB header:viral protein Chain: B: PDB Molecule:cricket paralysis virus 1a protein; PDBTitle: cricket paralysis virus rnai suppressor protein crpv-1a Phyre2 PDB 3v46 chain A Region: 83 - 92 Aligned: 10 Modelled: 10 Confidence: 16.6% Identity: 40% PDB header:transcription Chain: A: PDB Molecule:cell division control protein 73; PDBTitle: crystal structure of yeast cdc73 c-terminal domain Phyre2 PDB 1afr chain A Region: 13 - 47 Aligned: 35 Modelled: 35 Confidence: 15.9% Identity: 26% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1qhk chain A Region: 47 - 92 Aligned: 33 Modelled: 46 Confidence: 15.7% Identity: 42% Fold: MbtH/L9 domain-like Superfamily: L9 N-domain-like Family: N-terminal domain of RNase HI Phyre2 PDB 1joi chain A Region: 36 - 102 Aligned: 67 Modelled: 67 Confidence: 11.8% Identity: 12% Fold: Cupredoxin-like Superfamily: Cupredoxins Family: Plastocyanin/azurin-like Phyre2 PDB 1nye chain D Region: 26 - 38 Aligned: 13 Modelled: 13 Confidence: 11.1% Identity: 31% Fold: OsmC-like Superfamily: OsmC-like Family: Ohr/OsmC resistance proteins Phyre2 PDB 3ts9 chain A Region: 42 - 54 Aligned: 13 Modelled: 13 Confidence: 11.1% Identity: 31% PDB header:antiviral protein, hydrolase Chain: A: PDB Molecule:interferon-induced helicase c domain-containing protein 1; PDBTitle: crystal structure of the mda5 helicase insert domain Phyre2 PDB 6f46 chain A Region: 9 - 19 Aligned: 11 Modelled: 11 Confidence: 10.4% Identity: 64% PDB header:apoptosis Chain: A: PDB Molecule:bcl-2-like protein 1; PDBTitle: structure of the transmembrane helix of bclxl in phospholipid2 nanodiscs Phyre2 PDB 5wod chain A Region: 99 - 112 Aligned: 14 Modelled: 14 Confidence: 9.4% Identity: 36% PDB header:de novo protein Chain: A: PDB Molecule:38-mer peptide; PDBTitle: de novo design of covalently constrained meso-size protein scaffolds2 with unique tertiary structures Phyre2 PDB 1rkr chain A Region: 32 - 107 Aligned: 76 Modelled: 76 Confidence: 8.6% Identity: 14% Fold: Cupredoxin-like Superfamily: Cupredoxins Family: Plastocyanin/azurin-like Phyre2 1 c3ismC_ 2 c6nhwA_ 3 c6nhwB_ 4 c6nhwC_ 5 c6nhwD_ 6 c6nhwF_ 7 c6nhwE_ 8 d1mg7a1 9 c1mg7B_ 10 d2euca1 11 c6c3rB_ 12 c3v46A_ 13 d1afra_ 14 d1qhka_ 15 d1joia_ 16 d1nyed_ 17 c3ts9A_ 18 c6f46A_ 19 c5wodA_ 20 d1rkra_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43