1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	W	H	P	H	A	N	R	L	K	T	F	L	L	L	V	G	M	S	A	L	I	V	A	V	G	A	L	F	G	R	T	A	L	M	L	A	A	L	F	A	V	G	M	N	V	Y	V	Y	F	N	S	D	K	L	A	L	R	A
Secondary structure
SS confidence
Disorder		?	?	?																																																	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	H	A	Q	P	V	S	E	L	Q	A	P	A	M	Y	R	I	V	R	E	L	A	T	S	A	H	Q	P	M	P	R	L	Y	I	S	D	T	A	A	P	N	A	F	A	T	G	R	N	P	R	N	A	A	V	C	C	T	T	G	I
Secondary structure
SS confidence
Disorder			?	?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	R	I	L	N	E	R	E	L	R	A	V	L	G	H	E	L	S	H	V	Y	N	R	D	I	L	I	S	C	V	A	G	A	L	A	A	V	I	T	A	L	A	N	M	A	M	W	A	G	M	F	G	G	N	R	D	N	A	N	P
Secondary structure
SS confidence
Disorder																																																			?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	A	L	L	L	V	A	L	L	G	P	I	A	A	T	V	I	R	M	A	V	S	R	S	R	E	Y	Q	A	D	E	S	G	A	V	L	T	G	D	P	L	A	L	A	S	A	L	R	K	I	S	G	G	V	Q	A	A	P	L	P
Secondary structure
SS confidence
Disorder																																																						?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.
Sequence		P	E	P	Q	L	A	S	Q	A	H	L	M	I	A	N	P	F	R	A	G	E	R	I	G	S	L	F	S	T	H	P	P	I	E	D	R	I	R	R	L	E	A	M	A	R	G
Secondary structure
SS confidence
Disorder		?	?	?	?										?	?		?	?	?	?	?																							?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 71%) Beta strand ( 6%) TM helix ( 28%) (View membrane topology prediction)

Rank Aligned region

PDB 4aw6 chain B Region: 3 - 283 Aligned: 259 Modelled: 262 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:caax prenyl protease 1 homolog; PDBTitle: crystal structure of the human nuclear membrane zinc metalloprotease2 zmpste24 (face1) Phyre2 PDB 4il3 chain B Region: 3 - 281 Aligned: 257 Modelled: 260 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:ste24p; PDBTitle: crystal structure of s. mikatae ste24p Phyre2 PDB 3c37 chain B Region: 67 - 284 Aligned: 160 Modelled: 164 Confidence: 99.9% Identity: 29% PDB header:hydrolase Chain: B: PDB Molecule:peptidase, m48 family; PDBTitle: x-ray structure of the putative zn-dependent peptidase q74d82 at the2 resolution 1.7 a. northeast structural genomics consortium target3 gsr143a Phyre2 PDB 6ait chain D Region: 70 - 285 Aligned: 162 Modelled: 166 Confidence: 99.8% Identity: 27% PDB header:hydrolase Chain: D: PDB Molecule:beta-barrel assembly-enhancing protease; PDBTitle: crystal structure of e. coli bepa Phyre2 PDB 3cqb chain B Region: 57 - 144 Aligned: 88 Modelled: 88 Confidence: 99.8% Identity: 34% PDB header:hydrolase Chain: B: PDB Molecule:probable protease htpx homolog; PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633 Phyre2 PDB 4jix chain B Region: 73 - 144 Aligned: 69 Modelled: 72 Confidence: 98.2% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:projannalysin; PDBTitle: crystal structure of the metallopeptidase zymogen of2 methanocaldococcus jannaschii jannalysin Phyre2 PDB 4jiu chain A Region: 74 - 144 Aligned: 67 Modelled: 71 Confidence: 97.1% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:proabylysin; PDBTitle: crystal structure of the metallopeptidase zymogen of pyrococcus abyssi2 abylysin Phyre2 PDB 3dtk chain A Region: 78 - 229 Aligned: 103 Modelled: 112 Confidence: 97.0% Identity: 16% PDB header:gene regulation Chain: A: PDB Molecule:irre protein; PDBTitle: crystal structure of the irre protein, a central regulator2 of dna damage repair in deinococcaceae Phyre2 PDB 6mdx chain A Region: 69 - 139 Aligned: 69 Modelled: 68 Confidence: 96.1% Identity: 13% PDB header:dna binding protein/dna Chain: A: PDB Molecule:sprt-like domain-containing protein spartan; PDBTitle: mechanism of protease dependent dpc repair Phyre2 PDB 6cz6 chain D Region: 68 - 229 Aligned: 118 Modelled: 122 Confidence: 94.0% Identity: 14% PDB header:transcription Chain: D: PDB Molecule:hth-type transcriptional regulator prpr; PDBTitle: mycobacterium tuberculosis transcriptional regulator Phyre2 PDB 3sks chain A Region: 72 - 143 Aligned: 64 Modelled: 72 Confidence: 93.4% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:putative oligoendopeptidase f; PDBTitle: crystal structure of a putative oligoendopeptidase f from bacillus2 anthracis str. ames Phyre2 PDB 5xbv chain A Region: 72 - 144 Aligned: 72 Modelled: 73 Confidence: 90.7% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:wss1p; PDBTitle: crystal structure of wss1 mutant from saccharomyces cerevisiae Phyre2 PDB 3ce2 chain A Region: 91 - 143 Aligned: 48 Modelled: 53 Confidence: 89.9% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative peptidase; PDBTitle: crystal structure of putative peptidase from chlamydophila abortus Phyre2 PDB 2gtq chain A Region: 72 - 139 Aligned: 65 Modelled: 68 Confidence: 88.9% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of aminopeptidase n from human pathogen neisseria2 meningitidis Phyre2 PDB 2h1j chain A Region: 76 - 143 Aligned: 63 Modelled: 68 Confidence: 88.9% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:oligoendopeptidase f; PDBTitle: 3.1 a x-ray structure of putative oligoendopeptidase f: crystals grown2 by microfluidic seeding Phyre2 PDB 1r55 chain A Region: 102 - 139 Aligned: 36 Modelled: 38 Confidence: 87.6% Identity: 19% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 3k7n chain A Region: 102 - 139 Aligned: 36 Modelled: 38 Confidence: 87.5% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:k-like; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins Phyre2 PDB 1yp1 chain A Region: 102 - 139 Aligned: 36 Modelled: 38 Confidence: 86.5% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:fii; PDBTitle: crystal structure of a non-hemorrhagic fibrin(ogen)olytic2 metalloproteinase from venom of agkistrodon acutus Phyre2 PDB 1bsw chain A Region: 102 - 139 Aligned: 36 Modelled: 38 Confidence: 86.2% Identity: 19% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 5zi7 chain A Region: 72 - 139 Aligned: 65 Modelled: 68 Confidence: 86.0% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase n; PDBTitle: crystal structure of legionella pneumophila aminopeptidase a in2 complex with glutamic acid Phyre2 1 c4aw6B_ 2 c4il3B_ 3 c3c37B_ 4 c6aitD_ 5 c3cqbB_ 6 c4jixB_ 7 c4jiuA_ 8 c3dtkA_ 9 c6mdxA_ 10 c6cz6D_ 11 c3sksA_ 12 c5xbvA_ 13 c3ce2A_ 14 c2gtqA_ 15 c2h1jA_ 16 d1r55a_ 17 c3k7nA_ 18 c1yp1A_ 19 d1bswa_ 20 c5zi7A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172