1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	G	V	S	W	P	A	K	V	R	R	R	D	G	T	L	V	P	F	D	I	A	R	I	E	A	A	V	T	R	A	A	R	E	V	A	C	D	D	P	D	M	P	G	T	V	A	K	A	V	A	D	A	L	G	R	G	I	A	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	E	D	I	Q	D	C	V	E	A	R	L	G	E	A	G	L	D	D	V	A	R	V	Y	I	I	Y	R	Q	R	R	A	E	L	R	T	A	K	A	L	L	G	V	R	D	E	L	K	L	S	L	A	A	V	T	V	L	R	E	R
Secondary structure
SS confidence
Disorder																																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Y	L	L	H	D	E	Q	G	R	P	A	E	S	T	G	E	L	M	D	R	S	A	R	C	V	A	A	A	E	D	Q	Y	E	P	G	S	S	R	R	W	A	E	R	F	A	T	L	L	R	N	L	E	F	L	P	N	S	P	T	L
Secondary structure
SS confidence
Disorder																																	?	?	?	?	?	?													?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		M	N	S	G	T	D	L	G	L	L	A	G	C	F	V	L	P	I	E	D	S	L	Q	S	I	F	A	T	L	G	Q	A	A	E	L	Q	R	A	G	G	G	T	G	Y	A	F	S	H	L	R	P	A	G	D	R	V	A	S	T	G
Secondary structure
SS confidence
Disorder							?																																																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	T	A	S	G	P	V	S	F	L	R	L	Y	D	S	A	A	G	V	V	S	M	G	G	R	R	R	G	A	C	M	A	V	L	D	V	S	H	P	D	I	C	D	F	V	T	A	K	A	E	S	P	S	E	L	P	H	F	N	L
Secondary structure
SS confidence
Disorder		?																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	V	G	V	T	D	A	F	L	R	A	V	E	R	N	G	L	H	R	L	V	N	P	R	T	G	K	I	V	A	R	M	P	A	A	E	L	F	D	A	I	C	K	A	A	H	A	G	G	D	P	G	L	V	F	L	D	T	I	N
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	A	N	P	V	P	G	R	G	R	I	E	A	T	N	P	C	G	E	V	P	L	L	P	Y	E	S	C	N	L	G	S	I	N	L	A	R	M	L	A	D	G	R	V	D	W	D	R	L	E	E	V	A	G	V	A	V	R	F	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		D	D	V	I	D	V	S	R	Y	P	F	P	E	L	G	E	A	A	R	A	T	R	K	I	G	L	G	V	M	G	L	A	E	L	L	A	A	L	G	I	P	Y	D	S	E	E	A	V	R	L	A	T	R	L	M	R	R	I	Q	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		A	A	H	T	A	S	R	R	L	A	E	E	R	G	A	F	P	A	F	T	D	S	R	F	A	R	S	G	P	R	R	N	A	Q	V	T	S	V	A	P	T	G	T	I	S	L	I	A	G	T	T	A	G	I	E	P	M	F	A	I
Secondary structure
SS confidence
Disorder																										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		A	F	T	R	A	I	V	G	R	H	L	L	E	V	N	P	C	F	D	R	L	A	R	D	R	G	F	Y	R	D	E	L	I	A	E	I	A	Q	R	G	G	V	R	G	Y	P	R	L	P	A	E	V	R	A	A	F	P	T	A	A
Secondary structure
SS confidence
Disorder									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		E	I	A	P	Q	W	H	L	R	M	Q	A	A	V	Q	R	H	V	E	A	A	V	S	K	T	V	N	L	P	A	T	A	T	V	D	D	V	R	A	I	Y	V	A	A	W	K	A	K	V	K	G	I	T	V	Y	R	Y	G	S	R
Secondary structure
SS confidence
Disorder																																																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.
Sequence		E	G	Q	V	L	S	Y	A	A	P	K	P	L	L	A	Q	A	D	T	E	F	S	G	G	C	A	G	R	S	C	E	F
Secondary structure
SS confidence
Disorder			?			?	?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 48%) Beta strand ( 13%)

Rank Aligned region

PDB 5im3 chain A Region: 7 - 663 Aligned: 641 Modelled: 657 Confidence: 100.0% Identity: 30% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase; PDBTitle: crystal structure of the class i ribonucleotide reductase from2 pseudomonas aeruginosa in complex with datp Phyre2 PDB 1zyz chain A Region: 6 - 692 Aligned: 673 Modelled: 679 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase large chain 1; PDBTitle: structures of yeast ribonucloetide reductase i Phyre2 PDB 3hnf chain A Region: 5 - 660 Aligned: 634 Modelled: 656 Confidence: 100.0% Identity: 26% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase large subunit; PDBTitle: crystal structure of human ribonucleotide reductase 1 bound to the2 effectors ttp and datp Phyre2 PDB 3r1r chain B Region: 7 - 662 Aligned: 614 Modelled: 622 Confidence: 100.0% Identity: 24% PDB header:complex (oxidoreductase/peptide) Chain: B: PDB Molecule:ribonucleotide reductase r1 protein; PDBTitle: ribonucleotide reductase r1 protein with amppnp occupying2 the activity site from escherichia coli Phyre2 PDB 2cvu chain A Region: 60 - 660 Aligned: 583 Modelled: 593 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase large chain PDBTitle: structures of yeast ribonucleotide reductase i Phyre2 PDB 2wgh chain A Region: 45 - 660 Aligned: 581 Modelled: 611 Confidence: 100.0% Identity: 28% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase large PDBTitle: human ribonucleotide reductase r1 subunit (rrm1) in complex2 with datp and mg. Phyre2 PDB 3paw chain D Region: 7 - 660 Aligned: 635 Modelled: 635 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: D: PDB Molecule:ribonucleoside-diphosphate reductase large chain 1; PDBTitle: low resolution x-ray crystal structure of yeast rnr1p with datp bound2 in the a-site Phyre2 PDB 1pem chain A Region: 46 - 661 Aligned: 561 Modelled: 587 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase 2 alpha PDBTitle: ribonucleotide reductase protein r1e from salmonella2 typhimurium Phyre2 PDB 3rsr chain A Region: 60 - 660 Aligned: 550 Modelled: 583 Confidence: 100.0% Identity: 28% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase large chain 1; PDBTitle: crystal structure of 5-nitp inhibition of yeast ribonucleotide2 reductase Phyre2 PDB 1xje chain A Region: 96 - 659 Aligned: 559 Modelled: 564 Confidence: 100.0% Identity: 42% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleotide reductase, b12-dependent; PDBTitle: structural mechanism of allosteric substrate specificity in a2 ribonucleotide reductase: dttp-gdp complex Phyre2 PDB 6cgm chain A Region: 26 - 660 Aligned: 568 Modelled: 605 Confidence: 100.0% Identity: 23% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase; PDBTitle: x-ray crystal structure of bacillus subtilis ribonucleotide reductase2 nrde alpha subunit (nucleotide free) Phyre2 PDB 6dqx chain A Region: 102 - 668 Aligned: 504 Modelled: 532 Confidence: 100.0% Identity: 26% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase, alpha chain; PDBTitle: actinobacillus ureae class id ribonucleotide reductase alpha subunit Phyre2 PDB 6dqw chain B Region: 105 - 656 Aligned: 487 Modelled: 537 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: B: PDB Molecule:ribonucleoside-diphosphate reductase, alpha chain; PDBTitle: flavobacterium johnsoniae class id ribonucleotide reductase alpha2 subuint Phyre2 PDB 1rlr chain A domain 2 Region: 190 - 662 Aligned: 440 Modelled: 442 Confidence: 100.0% Identity: 27% Fold: PFL-like glycyl radical enzymes Superfamily: PFL-like glycyl radical enzymes Family: R1 subunit of ribonucleotide reductase, C-terminal domain Phyre2 PDB 1peq chain A domain 2 Region: 190 - 659 Aligned: 424 Modelled: 441 Confidence: 100.0% Identity: 33% Fold: PFL-like glycyl radical enzymes Superfamily: PFL-like glycyl radical enzymes Family: R1 subunit of ribonucleotide reductase, C-terminal domain Phyre2 PDB 1l1l chain A Region: 95 - 677 Aligned: 563 Modelled: 575 Confidence: 100.0% Identity: 20% Fold: PFL-like glycyl radical enzymes Superfamily: PFL-like glycyl radical enzymes Family: B12-dependent (class II) ribonucleotide reductase Phyre2 PDB 6dqw chain D Region: 122 - 656 Aligned: 379 Modelled: 429 Confidence: 100.0% Identity: 31% PDB header:oxidoreductase Chain: D: PDB Molecule:ribonucleoside-diphosphate reductase, alpha chain; PDBTitle: flavobacterium johnsoniae class id ribonucleotide reductase alpha2 subuint Phyre2 PDB 1rlr chain A domain 1 Region: 12 - 189 Aligned: 174 Modelled: 178 Confidence: 100.0% Identity: 18% Fold: R1 subunit of ribonucleotide reductase, N-terminal domain Superfamily: R1 subunit of ribonucleotide reductase, N-terminal domain Family: R1 subunit of ribonucleotide reductase, N-terminal domain Phyre2 PDB 1peq chain A domain 1 Region: 36 - 188 Aligned: 141 Modelled: 153 Confidence: 99.9% Identity: 16% Fold: R1 subunit of ribonucleotide reductase, N-terminal domain Superfamily: R1 subunit of ribonucleotide reductase, N-terminal domain Family: R1 subunit of ribonucleotide reductase, N-terminal domain Phyre2 PDB 5olk chain D Region: 6 - 112 Aligned: 102 Modelled: 107 Confidence: 99.7% Identity: 31% PDB header:oxidoreductase Chain: D: PDB Molecule:ribonucleoside-diphosphate reductase, beta subunit 1; PDBTitle: crystal structure of the atp-cone-containing nrdb from2 leeuwenhoekiella blandensis Phyre2 1 c5im3A_ 2 c1zyzA_ 3 c3hnfA_ 4 c3r1rB_ 5 c2cvuA_ 6 c2wghA_ 7 c3pawD_ 8 c1pemA_ 9 c3rsrA_ 10 c1xjeA_ 11 c6cgmA_ 12 c6dqxA_ 13 c6dqwB_ 14 d1rlra2 15 d1peqa2 16 d1l1la_ 17 c6dqwD_ 18 d1rlra1 19 d1peqa1 20 c5olkD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99