1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	I	R	Q	H	V	G	A	L	F	T	D	L	Y	E	V	T	M	A	Q	A	Y	W	A	E	R	M	S	G	T	A	V	F	E	I	F	F	R	K	L	P	P	G	R	S	Y	I	M	A	A	G	L	A	D	V	V	E	F	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	A	F	R	F	D	E	Q	D	L	R	Y	L	R	G	L	G	Q	F	S	D	E	F	L	R	W	L	A	G	V	R	F	T	G	D	V	W	A	A	P	E	G	T	V	I	F	P	N	E	P	A	V	Q	L	I	A	P	I	I	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	Q	L	V	E	T	F	V	L	N	Q	I	H	L	Q	S	V	L	A	S	K	A	A	R	V	V	A	A	A	R	G	R	P	V	V	D	F	G	A	R	R	A	H	G	T	D	A	A	C	K	V	A	R	T	S	Y	L	A	G	A
Secondary structure
SS confidence
Disorder																																										?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	G	T	S	N	L	L	A	A	R	Q	Y	G	I	P	T	F	G	T	M	A	H	S	F	V	Q	A	F	D	S	E	V	A	A	F	E	A	F	A	R	L	Y	P	A	T	M	L	L	V	D	T	Y	D	T	L	R	G	V	D	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	I	E	L	A	K	R	L	G	N	R	F	D	V	R	A	V	R	L	D	S	G	D	L	D	E	L	S	K	A	T	R	A	R	L	D	T	A	G	L	E	Q	V	E	I	F	A	S	S	G	L	D	E	N	R	I	A	A	L	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	A	R	C	P	I	D	G	F	G	V	G	T	Q	L	V	V	A	Q	D	A	P	A	L	D	M	A	Y	K	L	V	A	Y	D	G	S	G	R	T	K	F	S	S	G	K	V	I	Y	P	G	R	K	Q	V	F	R	K	L	E	H
Secondary structure
SS confidence
Disorder																																														?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	V	F	C	G	D	T	L	G	E	H	G	E	N	L	P	G	D	P	L	L	V	P	I	M	T	N	G	R	R	I	R	Q	H	A	P	T	L	D	G	A	R	D	W	A	R	Q	Q	I	D	A	L	P	P	E	L	R	S	L	E
Secondary structure
SS confidence
Disorder																?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.
Sequence		D	T	G	Y	S	Y	P	V	A	V	S	D	R	I	V	G	E	L	A	R	L	R	H	A	D	T	A	E	A	H	P	G	S	N	V	V	G	A	K	A	K	R	P
Secondary structure
SS confidence
Disorder																												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 45%) Beta strand ( 20%)

Rank Aligned region

PDB 2f7f chain A Region: 4 - 450 Aligned: 445 Modelled: 447 Confidence: 100.0% Identity: 39% PDB header:transferase Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase, putative; PDBTitle: crystal structure of enterococcus faecalis putative nicotinate2 phosphoribosyltransferase, new york structural genomics consortium Phyre2 PDB 4yub chain B Region: 10 - 441 Aligned: 414 Modelled: 432 Confidence: 100.0% Identity: 38% PDB header:ligase Chain: B: PDB Molecule:nicotinate phosphoribosyltransferase; PDBTitle: crystal structure of human nicotinic acid phosphoribosyltransferase Phyre2 PDB 4hl7 chain A Region: 6 - 354 Aligned: 339 Modelled: 337 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase; PDBTitle: crystal structure of nicotinate phosphoribosyltransferase (target2 nysgr-026035) from vibrio cholerae Phyre2 PDB 1yir chain A Region: 1 - 357 Aligned: 346 Modelled: 357 Confidence: 100.0% Identity: 27% PDB header:transferase Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase 2; PDBTitle: crystal structure of a nicotinate phosphoribosyltransferase Phyre2 PDB 1vlp chain A Region: 4 - 359 Aligned: 346 Modelled: 356 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase; PDBTitle: crystal structure of a putative nicotinate phosphoribosyltransferase2 (yor209c, npt1) from saccharomyces cerevisiae at 1.75 a resolution Phyre2 PDB 2im5 chain C Region: 6 - 356 Aligned: 339 Modelled: 351 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: C: PDB Molecule:nicotinate phosphoribosyltransferase; PDBTitle: crystal structure of nicotinate phosphoribosyltransferase from2 porphyromonas gingivalis Phyre2 PDB 3os4 chain A Region: 6 - 350 Aligned: 334 Modelled: 345 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase; PDBTitle: the crystal structure of nicotinate phosphoribosyltransferase from2 yersinia pestis Phyre2 PDB 1ybe chain A Region: 1 - 358 Aligned: 345 Modelled: 358 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase; PDBTitle: crystal structure of a nicotinate phosphoribosyltransferase Phyre2 PDB 2e5c chain A Region: 9 - 406 Aligned: 389 Modelled: 398 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:nicotinamide phosphoribosyltransferase; PDBTitle: crystal structure of human nmprtase complexed with 5'-phosphoribosyl-2 1'-pyrophosphate Phyre2 PDB 2i14 chain B Region: 6 - 416 Aligned: 366 Modelled: 382 Confidence: 100.0% Identity: 29% PDB header:transferase Chain: B: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: crystal structure of nicotinate-nucleotide2 pyrophosphorylase from pyrococcus furiosus Phyre2 PDB 2f7f chain A domain 1 Region: 138 - 450 Aligned: 311 Modelled: 313 Confidence: 100.0% Identity: 38% Fold: TIM beta/alpha-barrel Superfamily: Nicotinate/Quinolinate PRTase C-terminal domain-like Family: NadC C-terminal domain-like Phyre2 PDB 1ytk chain A Region: 6 - 413 Aligned: 361 Modelled: 379 Confidence: 100.0% Identity: 29% PDB header:transferase Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase from thermoplasma PDBTitle: crystal structure of a nicotinate phosphoribosyltransferase from2 thermoplasma acidophilum with nicotinate mononucleotide Phyre2 PDB 2i14 chain A domain 1 Region: 134 - 416 Aligned: 267 Modelled: 283 Confidence: 100.0% Identity: 31% Fold: TIM beta/alpha-barrel Superfamily: Nicotinate/Quinolinate PRTase C-terminal domain-like Family: NadC C-terminal domain-like Phyre2 PDB 1ytd chain A domain 1 Region: 139 - 413 Aligned: 259 Modelled: 275 Confidence: 100.0% Identity: 29% Fold: TIM beta/alpha-barrel Superfamily: Nicotinate/Quinolinate PRTase C-terminal domain-like Family: NadC C-terminal domain-like Phyre2 PDB 1yir chain A domain 1 Region: 138 - 357 Aligned: 215 Modelled: 220 Confidence: 100.0% Identity: 27% Fold: TIM beta/alpha-barrel Superfamily: Nicotinate/Quinolinate PRTase C-terminal domain-like Family: Monomeric nicotinate phosphoribosyltransferase C-terminal domain Phyre2 PDB 1ybe chain A domain 1 Region: 136 - 358 Aligned: 216 Modelled: 223 Confidence: 100.0% Identity: 22% Fold: TIM beta/alpha-barrel Superfamily: Nicotinate/Quinolinate PRTase C-terminal domain-like Family: Monomeric nicotinate phosphoribosyltransferase C-terminal domain Phyre2 PDB 1vlp chain A domain 2 Region: 141 - 358 Aligned: 211 Modelled: 218 Confidence: 100.0% Identity: 25% Fold: TIM beta/alpha-barrel Superfamily: Nicotinate/Quinolinate PRTase C-terminal domain-like Family: Monomeric nicotinate phosphoribosyltransferase C-terminal domain Phyre2 PDB 2f7f chain A domain 2 Region: 2 - 137 Aligned: 136 Modelled: 136 Confidence: 100.0% Identity: 38% Fold: alpha/beta-Hammerhead Superfamily: Nicotinate/Quinolinate PRTase N-terminal domain-like Family: NadC N-terminal domain-like Phyre2 PDB 1vlp chain A domain 1 Region: 6 - 134 Aligned: 129 Modelled: 129 Confidence: 100.0% Identity: 15% Fold: alpha/beta-Hammerhead Superfamily: Nicotinate/Quinolinate PRTase N-terminal domain-like Family: Monomeric nicotinate phosphoribosyltransferase N-terminal domain-like Phyre2 PDB 1yir chain A domain 2 Region: 4 - 134 Aligned: 125 Modelled: 131 Confidence: 100.0% Identity: 25% Fold: alpha/beta-Hammerhead Superfamily: Nicotinate/Quinolinate PRTase N-terminal domain-like Family: Monomeric nicotinate phosphoribosyltransferase N-terminal domain-like Phyre2 1 c2f7fA_ 2 c4yubB_ 3 c4hl7A_ 4 c1yirA_ 5 c1vlpA_ 6 c2im5C_ 7 c3os4A_ 8 c1ybeA_ 9 c2e5cA_ 10 c2i14B_ 11 d2f7fa1 12 c1ytkA_ 13 d2i14a1 14 d1ytda1 15 d1yira1 16 d1ybea1 17 d1vlpa2 18 d2f7fa2 19 d1vlpa1 20 d1yira2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187