1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	D	K	T	T	V	Y	L	P	D	E	L	K	A	A	V	K	R	A	A	R	Q	R	G	V	S	E	A	Q	V	I	R	E	S	I	R	A	A	V	G	G	A	K	P	P	P	R	G	G	L	Y	A	G	S	E	P	I	A	R	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?		?																?	?	?	?													?	?	?	?	?	?					?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.
Sequence		V	D	E	L	L	A	G	F	G	E	R
Secondary structure
SS confidence
Disorder								?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 34%) Alpha helix ( 61%) Beta strand ( 0%)

Rank Aligned region

PDB 5x3t chain A Region: 1 - 70 Aligned: 70 Modelled: 69 Confidence: 100.0% Identity: 97% PDB header:antitoxin/toxin Chain: A: PDB Molecule:antitoxin vapb26; PDBTitle: vapbc from mycobacterium tuberculosis Phyre2 PDB 2k5j chain B Region: 4 - 47 Aligned: 44 Modelled: 44 Confidence: 95.4% Identity: 18% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein yiif; PDBTitle: solution structure of protein yiif from shigella flexneri2 serotype 5b (strain 8401) . northeast structural genomics3 consortium target sft1 Phyre2 PDB 1q5v chain B Region: 1 - 53 Aligned: 53 Modelled: 53 Confidence: 92.7% Identity: 21% PDB header:transcription Chain: B: PDB Molecule:nickel responsive regulator; PDBTitle: apo-nikr Phyre2 PDB 2h1o chain H Region: 8 - 50 Aligned: 40 Modelled: 40 Confidence: 91.5% Identity: 30% PDB header:gene regulation/dna complex Chain: H: PDB Molecule:trafficking protein a; PDBTitle: structure of fitab bound to ir36 dna fragment Phyre2 PDB 2bj3 chain D Region: 1 - 54 Aligned: 54 Modelled: 54 Confidence: 91.1% Identity: 17% PDB header:transcription Chain: D: PDB Molecule:nickel responsive regulator; PDBTitle: nikr-apo Phyre2 PDB 2bsq chain E domain 1 Region: 8 - 50 Aligned: 40 Modelled: 43 Confidence: 91.1% Identity: 30% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: Trafficking protein A-like Phyre2 PDB 2bj7 chain A domain 1 Region: 1 - 39 Aligned: 39 Modelled: 39 Confidence: 89.1% Identity: 18% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 2hza chain A domain 1 Region: 1 - 39 Aligned: 39 Modelled: 38 Confidence: 87.4% Identity: 26% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 2hza chain B domain 1 Region: 1 - 39 Aligned: 39 Modelled: 38 Confidence: 85.8% Identity: 26% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 2ca9 chain B Region: 3 - 39 Aligned: 37 Modelled: 37 Confidence: 84.9% Identity: 22% PDB header:transcription Chain: B: PDB Molecule:putative nickel-responsive regulator; PDBTitle: apo-nikr from helicobacter pylori in closed trans-2 conformation Phyre2 PDB 2mvb chain A Region: 8 - 37 Aligned: 26 Modelled: 30 Confidence: 63.0% Identity: 38% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: nmr structure of the protein np_344732.1 from streptococcus pneumoniae2 tigr4 Phyre2 PDB 2kel chain B Region: 6 - 36 Aligned: 31 Modelled: 31 Confidence: 48.8% Identity: 26% PDB header:transcription repressor Chain: B: PDB Molecule:uncharacterized protein 56b; PDBTitle: structure of the transcription regulator svtr from the2 hyperthermophilic archaeal virus sirv1 Phyre2 PDB 6iya chain D Region: 1 - 39 Aligned: 39 Modelled: 39 Confidence: 44.5% Identity: 33% PDB header:antitoxin Chain: D: PDB Molecule:transcriptional regulator copg family; PDBTitle: structure of the dna binding domain of antitoxin copaso Phyre2 PDB 1mnt chain A Region: 2 - 64 Aligned: 61 Modelled: 63 Confidence: 43.9% Identity: 25% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: Arc/Mnt-like phage repressors Phyre2 PDB 2rbf chain B Region: 4 - 39 Aligned: 36 Modelled: 36 Confidence: 43.4% Identity: 22% PDB header:oxidoreductase/dna Chain: B: PDB Molecule:bifunctional protein puta; PDBTitle: structure of the ribbon-helix-helix domain of escherichia coli puta2 (puta52) complexed with operator dna (o2) Phyre2 PDB 3kxe chain D Region: 4 - 36 Aligned: 33 Modelled: 33 Confidence: 38.8% Identity: 30% PDB header:protein binding Chain: D: PDB Molecule:antitoxin protein pard-1; PDBTitle: a conserved mode of protein recognition and binding in a2 pard-pare toxin-antitoxin complex Phyre2 PDB 3qoq chain C Region: 2 - 39 Aligned: 38 Modelled: 38 Confidence: 38.7% Identity: 24% PDB header:transcription/dna Chain: C: PDB Molecule:alginate and motility regulator z; PDBTitle: crystal structure of the transcription factor amrz in complex with the2 18 base pair amrz1 binding site Phyre2 PDB 5ceg chain C Region: 1 - 36 Aligned: 36 Modelled: 36 Confidence: 35.7% Identity: 22% PDB header:toxin Chain: C: PDB Molecule:addiction module antidote protein, copg/arc/metj family; PDBTitle: x-ray structure of toxin/anti-toxin complex from mesorhizobium2 opportunistum Phyre2 PDB 1qh4 chain A domain 1 Region: 7 - 65 Aligned: 57 Modelled: 59 Confidence: 35.7% Identity: 21% Fold: Guanido kinase N-terminal domain Superfamily: Guanido kinase N-terminal domain Family: Guanido kinase N-terminal domain Phyre2 PDB 1g0w chain A domain 1 Region: 7 - 65 Aligned: 57 Modelled: 59 Confidence: 32.5% Identity: 25% Fold: Guanido kinase N-terminal domain Superfamily: Guanido kinase N-terminal domain Family: Guanido kinase N-terminal domain Phyre2 1 c5x3tA_ 2 c2k5jB_ 3 c1q5vB_ 4 c2h1oH_ 5 c2bj3D_ 6 d2bsqe1 7 d2bj7a1 8 d2hzaa1 9 d2hzab1 10 c2ca9B_ 11 c2mvbA_ 12 c2kelB_ 13 c6iyaD_ 14 d1mnta_ 15 c2rbfB_ 16 c3kxeD_ 17 c3qoqC_ 18 c5cegC_ 19 d1qh4a1 20 d1g0wa1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60