1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	T	R	A	I	K	T	Q	L	V	L	L	T	V	L	A	V	I	A	V	V	V	L	G	W	Y	F	L	R	I	P	S	L	V	G	I	G	R	Y	T	L	Y	A	E	L	P	R	S	G	G	L	Y	R	T	A	N	V	T	Y
Secondary structure
SS confidence
Disorder		?	?	?	?																											?	?	?	?	?	?	?													?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	G	I	T	I	G	K	V	T	G	V	E	P	T	E	R	G	A	R	A	T	M	S	I	D	N	G	Y	Q	I	P	T	D	A	S	A	N	V	H	S	V	S	A	V	G	E	Q	F	V	D	L	V	S	T	R	T	S	G	P	Y
Secondary structure
SS confidence
Disorder															?												?				?										?	?	?	?	?	?											?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	R	H	G	Q	T	I	T	T	T	T	V	P	S	Q	I	G	P	A	L	D	A	A	N	R	G	L	A	V	L	P	K	D	R	V	A	S	V	L	H	E	A	S	E	A	V	G	G	L	G	S	S	L	N	R	L	I	E	A	T
Secondary structure
SS confidence
Disorder		?	?	?			?	?	?	?	?	?	?	?	?															?	?																	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Q	A	I	A	H	D	V	R	G	S	L	E	D	I	D	D	I	I	E	R	S	A	P	I	I	D	S	Q	V	N	S	G	N	E	I	A	R	W	A	A	N	L	N	T	L	A	A	Q	T	A	Q	T	D	P	A	V	R	S	I	L
Secondary structure
SS confidence
Disorder											?																																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	N	A	A	P	T	A	D	Q	V	N	A	T	F	S	D	V	R	E	S	L	P	Q	T	L	A	N	L	E	V	V	I	D	M	L	K	R	Y	H	N	G	V	E	Q	A	L	V	F	L	P	Q	S	G	A	I	A	Q	S	V	T
Secondary structure
SS confidence
Disorder																																																			?								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		T	E	F	P	G	Q	A	G	L	G	V	G	G	L	A	L	N	Q	P	P	P	C	L	T	G	F	L	P	A	S	E	W	R	S	P	A	D	T	S	T	A	P	L	P	K	G	T	Y	C	R	I	P	M	D	A	S	N	V	V	R
Secondary structure
SS confidence
Disorder		?																																								?	?	?		?	?				?		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	A	R	N	N	P	C	V	D	V	P	G	K	R	A	A	T	P	R	E	C	R	S	N	E	A	Y	V	P	G	G	T	N	P	W	Y	G	D	P	N	Q	M	L	S	C	P	A	P	A	A	R	C	D	Q	P	V	K	P	G	Q
Secondary structure
SS confidence
Disorder		?			?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?			?								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		V	I	P	A	P	S	V	N	N	G	I	N	P	L	P	A	D	Q	L	P	G	T	P	P	P	V	N	D	P	L	Q	R	P	G	S	G	T	V	Q	C	N	G	Q	Q	P	N	P	C	V	Y	T	P	S	T	F	P	T	T	I	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.
Sequence		D	V	Q	S	G	K	V	V	A	P	D	G	V	V	Y	S	V	E	A	S	T	H	A	G	A	D	G	W	K	V	M	L	A	P	T	G
Secondary structure
SS confidence
Disorder											?						?	?	?	?	?	?	?	?	?	?		?	?			?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 37%) Alpha helix ( 37%) Beta strand ( 9%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 6ic4 chain C Region: 10 - 141 Aligned: 131 Modelled: 132 Confidence: 99.9% Identity: 26% PDB header:protein transport Chain: C: PDB Molecule:toluene tolerance efflux transporter (abc superfamily, PDBTitle: cryo-em structure of the a. baumannii mla complex at 8.7 a resolution Phyre2 PDB 5uw8 chain C Region: 37 - 133 Aligned: 97 Modelled: 97 Confidence: 99.8% Identity: 26% PDB header:transport protein Chain: C: PDB Molecule:probable phospholipid abc transporter-binding protein mlad; PDBTitle: structure of e. coli mce protein mlad, core mce domain Phyre2 PDB 5uvn chain C Region: 36 - 152 Aligned: 106 Modelled: 117 Confidence: 99.4% Identity: 20% PDB header:transport protein Chain: C: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain D Region: 36 - 152 Aligned: 106 Modelled: 117 Confidence: 99.4% Identity: 20% PDB header:transport protein Chain: D: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain B Region: 36 - 152 Aligned: 106 Modelled: 117 Confidence: 99.4% Identity: 20% PDB header:transport protein Chain: B: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain E Region: 36 - 152 Aligned: 106 Modelled: 117 Confidence: 99.4% Identity: 20% PDB header:transport protein Chain: E: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain A Region: 36 - 152 Aligned: 106 Modelled: 117 Confidence: 99.4% Identity: 20% PDB header:transport protein Chain: A: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain F Region: 36 - 152 Aligned: 106 Modelled: 117 Confidence: 99.4% Identity: 20% PDB header:transport protein Chain: F: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 1qu7 chain A Region: 136 - 292 Aligned: 155 Modelled: 157 Confidence: 96.1% Identity: 12% PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein i; PDBTitle: four helical-bundle structure of the cytoplasmic domain of a serine2 chemotaxis receptor Phyre2 PDB 3g67 chain A Region: 136 - 299 Aligned: 162 Modelled: 164 Confidence: 94.0% Identity: 11% PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein; PDBTitle: crystal structure of a soluble chemoreceptor from thermotoga2 maritima Phyre2 PDB 3cwg chain A Region: 136 - 270 Aligned: 135 Modelled: 135 Confidence: 93.9% Identity: 13% PDB header:transcription Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: unphosphorylated mouse stat3 core fragment Phyre2 PDB 5xbj chain A Region: 136 - 259 Aligned: 114 Modelled: 124 Confidence: 93.1% Identity: 16% PDB header:biosynthetic protein Chain: A: PDB Molecule:flagellar hook-associated protein flgk; PDBTitle: the structure of the flagellar hook junction protein hap1 (flgk) from2 campylobacter jejuni Phyre2 PDB 4ut1 chain A Region: 136 - 259 Aligned: 112 Modelled: 124 Confidence: 91.7% Identity: 13% PDB header:motor protein Chain: A: PDB Molecule:flagellar hook-associated protein; PDBTitle: the structure of the flagellar hook junction protein flgk2 from burkholderia pseudomallei Phyre2 PDB 3lnr chain A Region: 159 - 268 Aligned: 110 Modelled: 110 Confidence: 90.1% Identity: 16% PDB header:signaling protein Chain: A: PDB Molecule:aerotaxis transducer aer2; PDBTitle: crystal structure of poly-hamp domains from the p. aeruginosa soluble2 receptor aer2 Phyre2 PDB 5u0p chain U Region: 153 - 258 Aligned: 106 Modelled: 106 Confidence: 88.8% Identity: 8% PDB header:transcription Chain: U: PDB Molecule:mediator complex subunit 21; PDBTitle: cryo-em structure of the transcriptional mediator Phyre2 PDB 3zx6 chain A Region: 164 - 284 Aligned: 121 Modelled: 121 Confidence: 88.7% Identity: 9% PDB header:signaling Chain: A: PDB Molecule:hamp, methyl-accepting chemotaxis protein i; PDBTitle: structure of hamp(af1503)-tsr fusion - hamp (a291v) mutant Phyre2 PDB 2ch7 chain A Region: 136 - 298 Aligned: 163 Modelled: 163 Confidence: 88.2% Identity: 13% PDB header:chemotaxis Chain: A: PDB Molecule:methyl-accepting chemotaxis protein; PDBTitle: crystal structure of the cytoplasmic domain of a bacterial2 chemoreceptor from thermotoga maritima Phyre2 PDB 6e6a chain B Region: 139 - 294 Aligned: 151 Modelled: 156 Confidence: 87.4% Identity: 17% PDB header:protein binding Chain: B: PDB Molecule:inclusion membrane protein a; PDBTitle: triclinic crystal form of inca g144a point mutant Phyre2 PDB 1deq chain F Region: 152 - 256 Aligned: 105 Modelled: 105 Confidence: 84.5% Identity: 10% PDB header:blood clotting Chain: F: PDB Molecule:fibrinogen (gamma chain); PDBTitle: the crystal structure of modified bovine fibrinogen (at ~42 angstrom resolution) Phyre2 PDB 2ieq chain C Region: 171 - 260 Aligned: 88 Modelled: 90 Confidence: 84.1% Identity: 11% PDB header:viral protein Chain: C: PDB Molecule:spike glycoprotein; PDBTitle: core structure of s2 from the human coronavirus nl63 spike2 glycoprotein Phyre2 1 c6ic4C_ 2 c5uw8C_ 3 c5uvnC_ 4 c5uvnD_ 5 c5uvnB_ 6 c5uvnE_ 7 c5uvnA_ 8 c5uvnF_ 9 c1qu7A_ 10 c3g67A_ 11 c3cwgA_ 12 c5xbjA_ 13 c4ut1A_ 14 c3lnrA_ 15 c5u0pU_ 16 c3zx6A_ 17 c2ch7A_ 18 c6e6aB_ 19 c1deqF_ 20 c2ieqC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161