1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	L	V	L	A	A	A	G	A	V	T	V	V	Q	F	R	D	A	A	H	E	A	D	P	D	G	A	L	R	G	L	T	D	D	I	T	A	D	L	V	R	E	L	V	T	I	L	P	I	V	L	V	I	A	A	V	A	A	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?													?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	L	S	R	A	A	L	R	P	V	D	R	I	R	A	A	A	Q	T	L	T	T	T	P	H	P	D	T	D	A	P	L	P	V	P	P	T	D	D	E	I	A	W	L	A	T	T	L	N	T	M	L	T	R	L	Q	R	A	L	A
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?	?					?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.
Sequence		H	E	Q	Q	F	V	A	D	A	S	H	E	L	R	T	P	L	A	L	L	T	T	E	L	E	L	R	C	A	G	P	D	P	P	T	S
Secondary structure
SS confidence
Disorder																														?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 24%) Alpha helix ( 66%) Beta strand ( 4%) TM helix ( 14%) (View membrane topology prediction)

Rank Aligned region

PDB 3zrw chain B Region: 65 - 151 Aligned: 84 Modelled: 87 Confidence: 99.6% Identity: 23% PDB header:signaling protein Chain: B: PDB Molecule:af1503 protein, osmolarity sensor protein envz; PDBTitle: the structure of the dimeric hamp-dhp fusion a291v mutant Phyre2 PDB 4biu chain B Region: 68 - 154 Aligned: 78 Modelled: 87 Confidence: 99.2% Identity: 27% PDB header:transferase Chain: B: PDB Molecule:sensor protein cpxa; PDBTitle: crystal structure of cpxahdc (orthorhombic form 1) Phyre2 PDB 4mt8 chain A Region: 99 - 154 Aligned: 56 Modelled: 56 Confidence: 99.2% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:ethylene response sensor 1; PDBTitle: structure of the ers1 dimerization and histidine phosphotransfer2 domain from arabidopsis thaliana Phyre2 PDB 5ukv chain A Region: 110 - 154 Aligned: 45 Modelled: 43 Confidence: 99.1% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:atp-binding protein; PDBTitle: dhp domain of phor of m. tuberculosis - semet Phyre2 PDB 4gn0 chain D Region: 33 - 124 Aligned: 89 Modelled: 92 Confidence: 99.0% Identity: 17% PDB header:signaling protein Chain: D: PDB Molecule:hamp domain of af1503; PDBTitle: de novo phasing of a hamp-complex using an improved arcimboldo method Phyre2 PDB 1joy chain A Region: 111 - 152 Aligned: 42 Modelled: 42 Confidence: 98.9% Identity: 24% Fold: ROP-like Superfamily: Homodimeric domain of signal transducing histidine kinase Family: Homodimeric domain of signal transducing histidine kinase Phyre2 PDB 2c2a chain A domain 1 Region: 109 - 156 Aligned: 48 Modelled: 48 Confidence: 98.9% Identity: 31% Fold: ROP-like Superfamily: Homodimeric domain of signal transducing histidine kinase Family: Homodimeric domain of signal transducing histidine kinase Phyre2 PDB 5jef chain A Region: 33 - 117 Aligned: 78 Modelled: 85 Confidence: 98.8% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:nitrate/nitrite sensor protein narq; PDBTitle: fragment of nitrate/nitrite sensor histidine kinase narq (wt) in2 asymmetric holo state Phyre2 PDB 2c2a chain A Region: 109 - 156 Aligned: 48 Modelled: 48 Confidence: 98.6% Identity: 31% PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein Phyre2 PDB 3lnr chain A Region: 58 - 145 Aligned: 84 Modelled: 88 Confidence: 98.3% Identity: 14% PDB header:signaling protein Chain: A: PDB Molecule:aerotaxis transducer aer2; PDBTitle: crystal structure of poly-hamp domains from the p. aeruginosa soluble2 receptor aer2 Phyre2 PDB 4cti chain A Region: 66 - 145 Aligned: 77 Modelled: 80 Confidence: 98.1% Identity: 25% PDB header:signaling protein Chain: A: PDB Molecule:osmolarity sensor protein envz, af1503; PDBTitle: escherichia coli envz histidine kinase catalytic part fused to2 archaeoglobus fulgidus af1503 hamp domain Phyre2 PDB 3zx6 chain A Region: 66 - 147 Aligned: 79 Modelled: 82 Confidence: 97.5% Identity: 14% PDB header:signaling Chain: A: PDB Molecule:hamp, methyl-accepting chemotaxis protein i; PDBTitle: structure of hamp(af1503)-tsr fusion - hamp (a291v) mutant Phyre2 PDB 2asx chain A domain 1 Region: 65 - 120 Aligned: 53 Modelled: 56 Confidence: 97.5% Identity: 23% Fold: HAMP domain-like Superfamily: HAMP domain-like Family: HAMP domain Phyre2 PDB 2q8f chain A Region: 99 - 149 Aligned: 51 Modelled: 51 Confidence: 97.2% Identity: 6% PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1 Phyre2 PDB 3d2r chain B Region: 57 - 149 Aligned: 89 Modelled: 93 Confidence: 96.9% Identity: 11% PDB header:transferase Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4; PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp Phyre2 PDB 3gie chain A Region: 97 - 154 Aligned: 58 Modelled: 58 Confidence: 95.7% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase desk; PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp Phyre2 PDB 1y8o chain A Region: 97 - 149 Aligned: 53 Modelled: 53 Confidence: 95.6% Identity: 6% PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3; PDBTitle: crystal structure of the pdk3-l2 complex Phyre2 PDB 3crl chain B Region: 99 - 149 Aligned: 51 Modelled: 51 Confidence: 95.2% Identity: 8% PDB header:transferase Chain: B: PDB Molecule:pyruvate dehydrogenase [lipoamide] kinase isozyme 2, PDBTitle: crystal structure of the pdhk2-l2 complex. Phyre2 PDB 4i5s chain A Region: 67 - 124 Aligned: 54 Modelled: 58 Confidence: 95.2% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:putative histidine kinase covs; vick-like protein; PDBTitle: structure and function of sensor histidine kinase Phyre2 PDB 2rm8 chain A Region: 83 - 135 Aligned: 52 Modelled: 53 Confidence: 92.5% Identity: 21% PDB header:signaling protein Chain: A: PDB Molecule:sensory rhodopsin ii transducer; PDBTitle: the solution structure of phototactic transducer protein2 htrii linker region from natronomonas pharaonis Phyre2 1 c3zrwB_ 2 c4biuB_ 3 c4mt8A_ 4 c5ukvA_ 5 c4gn0D_ 6 d1joya_ 7 d2c2aa1 8 c5jefA_ 9 c2c2aA_ 10 c3lnrA_ 11 c4ctiA_ 12 c3zx6A_ 13 d2asxa1 14 c2q8fA_ 15 c3d2rB_ 16 c3gieA_ 17 c1y8oA_ 18 c3crlB_ 19 c4i5sA_ 20 c2rm8A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43