1

.

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.

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.

10

.

.

.

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.

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20

.

.

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30

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40

.

.

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.

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50

.

.

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.

.

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60

Sequence

M

N

R

I

V

Q

F

G

V

S

A

V

A

A

A

A

I

G

I

G

A

G

S

G

I

A

A

A

F

D

G

E

D

E

V

T

G

P

D

A

D

R

A

R

A

A

A

V

Q

A

V

P

G

G

T

A

G

E

V

E

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

70

.

.

.

.

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.

.

.

80

.

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.

.

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.

.

.

90

.

.

.

.

.

.

.

.

.

100

.

.

.

Sequence

T

E

T

G

E

G

A

A

A

Y

G

V

L

V

T

R

P

D

G

T

R

V

E

V

H

L

D

R

D

F

R

V

L

D

T

E

P

A

D

G

D

G

G

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 49%) Alpha helix ( 28%) Beta strand ( 34%)

Rank Aligned region

PDB 2kgy chain A Region: 12 - 103 Aligned: 92 Modelled: 92 Confidence: 100.0% Identity: 84% PDB header:immune system Chain: A: PDB Molecule:possible exported protein; PDBTitle: solution structure of rv0603 protein from mycobacterium2 tuberculosis h37rv Phyre2 PDB 4exr chain A Region: 41 - 87 Aligned: 45 Modelled: 47 Confidence: 74.9% Identity: 18% PDB header:unknown function Chain: A: PDB Molecule:putative lipoprotein; PDBTitle: crystal structure of a putative lipoprotein (cd1622) from clostridium2 difficile 630 at 1.85 a resolution Phyre2 PDB 2vld chain A Region: 71 - 91 Aligned: 20 Modelled: 21 Confidence: 58.6% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:endonuclease nucs; PDBTitle: crystal structure of a repair endonuclease from pyrococcus abyssi Phyre2 PDB 5gke chain B Region: 71 - 91 Aligned: 20 Modelled: 21 Confidence: 57.0% Identity: 25% PDB header:hydrolase/dna Chain: B: PDB Molecule:endonuclease endoms; PDBTitle: structure of endoms-dsdna1 complex Phyre2 PDB 3riq chain A Region: 68 - 86 Aligned: 19 Modelled: 19 Confidence: 21.5% Identity: 37% PDB header:viral protein Chain: A: PDB Molecule:tailspike protein; PDBTitle: siphovirus 9na tailspike receptor binding domain Phyre2 PDB 3hd4 chain A Region: 74 - 97 Aligned: 24 Modelled: 24 Confidence: 19.9% Identity: 29% PDB header:viral protein Chain: A: PDB Molecule:nucleoprotein; PDBTitle: mhv nucleocapsid protein ntd Phyre2 PDB 1s21 chain A Region: 55 - 86 Aligned: 32 Modelled: 32 Confidence: 18.3% Identity: 31% Fold: ADP-ribosylation Superfamily: ADP-ribosylation Family: AvrPphF ORF2, a type III effector Phyre2 PDB 1s21 chain A Region: 55 - 86 Aligned: 32 Modelled: 32 Confidence: 18.3% Identity: 31% PDB header:chaperone Chain: A: PDB Molecule:orf2; PDBTitle: crystal structure of avrpphf orf2, a type iii effector from p.2 syringae Phyre2 PDB 2cjo chain A Region: 68 - 94 Aligned: 27 Modelled: 27 Confidence: 13.6% Identity: 37% Fold: beta-Grasp (ubiquitin-like) Superfamily: 2Fe-2S ferredoxin-like Family: 2Fe-2S ferredoxin-related Phyre2 PDB 6hos chain B Region: 58 - 82 Aligned: 25 Modelled: 25 Confidence: 13.6% Identity: 28% PDB header:cell adhesion Chain: B: PDB Molecule:ba75_04148t0; PDBTitle: structure of the kpflo2 adhesin domain in complex with glycerol Phyre2 PDB 3due chain A domain 1 Region: 42 - 96 Aligned: 53 Modelled: 55 Confidence: 13.2% Identity: 17% Fold: BLIP-like Superfamily: BT0923-like Family: BT0923-like Phyre2 PDB 2gyc chain 3 domain 1 Region: 7 - 20 Aligned: 14 Modelled: 14 Confidence: 11.8% Identity: 64% Fold: Ribosomal protein L7/12, oligomerisation (N-terminal) domain Superfamily: Ribosomal protein L7/12, oligomerisation (N-terminal) domain Family: Ribosomal protein L7/12, oligomerisation (N-terminal) domain Phyre2 PDB 4v19 chain 4 Region: 70 - 93 Aligned: 24 Modelled: 24 Confidence: 11.6% Identity: 29% PDB header:ribosome Chain: 4: PDB Molecule:mitoribosomal protein bl31m, mrpl55; PDBTitle: structure of the large subunit of the mammalian mitoribosome, part 12 of 2 Phyre2 PDB 5n76 chain C Region: 72 - 84 Aligned: 13 Modelled: 13 Confidence: 10.6% Identity: 54% PDB header:nickel-binding protein Chain: C: PDB Molecule:coot; PDBTitle: crystal structure of the apo-form of the co dehydrogenase accessory2 protein coot from rhodospirillum rubrum Phyre2 PDB 2d7n chain A domain 1 Region: 55 - 86 Aligned: 32 Modelled: 32 Confidence: 10.5% Identity: 9% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Filamin repeat (rod domain) Phyre2 PDB 5e4r chain A Region: 21 - 61 Aligned: 40 Modelled: 41 Confidence: 9.4% Identity: 28% PDB header:oxidoreductase Chain: A: PDB Molecule:ketol-acid reductoisomerase; PDBTitle: crystal structure of domain-duplicated synthetic class ii ketol-acid2 reductoisomerase 2ia_kari-dd Phyre2 PDB 5xcx chain B Region: 78 - 100 Aligned: 23 Modelled: 23 Confidence: 9.3% Identity: 22% PDB header:immune system Chain: B: PDB Molecule:vl-sarah(s37c) chimera; PDBTitle: crystal structure of ts2/16 fv-clasp fragment Phyre2 PDB 1dlj chain A domain 2 Region: 15 - 50 Aligned: 36 Modelled: 36 Confidence: 8.9% Identity: 22% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: 6-phosphogluconate dehydrogenase-like, N-terminal domain Phyre2 PDB 1v2y chain A Region: 64 - 94 Aligned: 31 Modelled: 31 Confidence: 8.5% Identity: 29% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 3d8t chain B Region: 69 - 78 Aligned: 10 Modelled: 10 Confidence: 7.2% Identity: 0% PDB header:lyase Chain: B: PDB Molecule:uroporphyrinogen-iii synthase; PDBTitle: thermus thermophilus uroporphyrinogen iii synthase Phyre2 1 c2kgyA_ 2 c4exrA_ 3 c2vldA_ 4 c5gkeB_ 5 c3riqA_ 6 c3hd4A_ 7 d1s21a_ 8 c1s21A_ 9 d2cjoa_ 10 c6hosB_ 11 d3duea1 12 d2gyc31 13 c4v194_ 14 c5n76C_ 15 d2d7na1 16 c5e4rA_ 17 c5xcxB_ 18 d1dlja2 19 d1v2ya_ 20 c3d8tB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39