1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	R	L	E	I	P	N	G	W	C	V	Q	A	F	R	F	T	L	D	P	T	A	E	Q	A	H	A	L	A	R	H	F	G	A	R	R	K	A	Y	N	W	T	V	A	Q	L	K	A	D	I	Q	A	W	R	A	T	G	A	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	A	K	P	S	L	R	V	L	R	K	R	W	N	T	V	K	D	E	V	C	V	N	A	E	T	G	T	V	W	W	P	E	C	S	K	E	A	Y	A	D	G	I	A	G	A	V	D	A	Y	W	N	W	Q	Q	R	R	A	G	K
Secondary structure
SS confidence
Disorder																					?			?	?																																?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	D	G	K	R	M	G	F	P	R	F	K	K	K	G	R	D	A	D	R	V	S	F	T	T	G	A	M	R	V	E	P	D	R	R	H	L	T	L	P	V	I	G	C	V	R	T	H	E	N	T	R	R	I	E	R	L	I	A	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?					?	?		?																																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	R	A	R	V	L	A	I	T	V	R	R	N	G	T	R	L	D	A	S	V	R	V	L	V	Q	R	P	Q	Q	P	N	V	E	L	P	E	S	R	I	G	V	D	V	G	V	R	R	L	A	T	V	A	T	A	D	G	A	C	C
Secondary structure
SS confidence
Disorder		?																											?	?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.
Sequence		P	V	L	V	P	D	G
Secondary structure
SS confidence
Disorder					?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 32%) Beta strand ( 28%)

Rank Aligned region

PDB 1kcf chain B Region: 212 - 232 Aligned: 21 Modelled: 21 Confidence: 89.8% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:hypothetical 30.2 kd protein c25g10.02 in PDBTitle: crystal structure of the yeast mitochondrial holliday2 junction resolvase, ydc2 Phyre2 PDB 5j3b chain B Region: 218 - 247 Aligned: 30 Modelled: 30 Confidence: 67.2% Identity: 23% PDB header:translation Chain: B: PDB Molecule:elongation factor p; PDBTitle: structure of translation elongation factor p from acinetobacter2 baumannii Phyre2 PDB 5id6 chain A Region: 195 - 237 Aligned: 43 Modelled: 43 Confidence: 65.5% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:cpf1; PDBTitle: structure of cpf1/rna complex Phyre2 PDB 5wqe chain A Region: 218 - 233 Aligned: 16 Modelled: 16 Confidence: 60.6% Identity: 31% PDB header:rna binding protein Chain: A: PDB Molecule:crispr-associated endonuclease c2c1; PDBTitle: crystal structure of alicyclobacillus acidoterrestris c2c1 in complex2 with single-guide rna at 3.1 angstrom resolution Phyre2 PDB 5u31 chain A Region: 218 - 233 Aligned: 16 Modelled: 16 Confidence: 46.3% Identity: 25% PDB header:hydrolase/dna Chain: A: PDB Molecule:crispr-associated endonuclease c2c1; PDBTitle: crystal structure of aacc2c1-sgrna-8mer substrate dna ternary complex Phyre2 PDB 3oyy chain A Region: 202 - 247 Aligned: 40 Modelled: 46 Confidence: 39.3% Identity: 10% PDB header:translation Chain: A: PDB Molecule:elongation factor p; PDBTitle: structure of pseudomonas aeruginosa elongation factor p Phyre2 PDB 3a5z chain D Region: 200 - 247 Aligned: 32 Modelled: 32 Confidence: 32.1% Identity: 28% PDB header:ligase Chain: D: PDB Molecule:elongation factor p; PDBTitle: crystal structure of escherichia coli genx in complex with elongation2 factor p Phyre2 PDB 1ueb chain A domain 3 Region: 225 - 247 Aligned: 23 Modelled: 23 Confidence: 29.4% Identity: 30% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Cold shock DNA-binding domain-like Phyre2 PDB 1ueb chain B Region: 202 - 247 Aligned: 36 Modelled: 36 Confidence: 28.2% Identity: 25% PDB header:rna binding protein Chain: B: PDB Molecule:elongation factor p; PDBTitle: crystal structure of translation elongation factor p from2 thermus thermophilus hb8 Phyre2 PDB 1yby chain B Region: 218 - 247 Aligned: 30 Modelled: 30 Confidence: 25.7% Identity: 23% PDB header:translation Chain: B: PDB Molecule:translation elongation factor p; PDBTitle: conserved hypothetical protein cth-95 from clostridium thermocellum Phyre2 PDB 1x2n chain A domain 1 Region: 20 - 52 Aligned: 33 Modelled: 33 Confidence: 25.3% Identity: 18% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: Homeodomain Phyre2 PDB 2oce chain A Region: 212 - 247 Aligned: 36 Modelled: 36 Confidence: 21.2% Identity: 22% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein pa5201; PDBTitle: crystal structure of tex family protein pa5201 from2 pseudomonas aeruginosa Phyre2 PDB 1g4m chain A domain 1 Region: 210 - 238 Aligned: 29 Modelled: 29 Confidence: 21.0% Identity: 24% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Arrestin/Vps26-like Phyre2 PDB 5b43 chain A Region: 195 - 237 Aligned: 43 Modelled: 43 Confidence: 18.0% Identity: 21% PDB header:hydrolase/rna/dna Chain: A: PDB Molecule:crispr-associated endonuclease cpf1; PDBTitle: crystal structure of acidaminococcus sp. cpf1 in complex with crrna2 and target dna Phyre2 PDB 6iv6 chain A Region: 195 - 233 Aligned: 39 Modelled: 39 Confidence: 15.8% Identity: 23% PDB header:immune system/rna Chain: A: PDB Molecule:nuclease; PDBTitle: cryo-em structure of acrva5-acetylated mbcas12a in complex with crrna Phyre2 PDB 1cf1 chain A domain 1 Region: 210 - 238 Aligned: 29 Modelled: 29 Confidence: 14.9% Identity: 31% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Arrestin/Vps26-like Phyre2 PDB 3f3h chain A Region: 221 - 244 Aligned: 22 Modelled: 24 Confidence: 14.8% Identity: 18% PDB header:antitumor protein Chain: A: PDB Molecule:immunomodulatory protein ling zhi-8; PDBTitle: crystal structure and anti-tumor activity of lz-8 from the fungus2 ganoderma lucidium Phyre2 PDB 2da7 chain A Region: 18 - 35 Aligned: 18 Modelled: 18 Confidence: 13.8% Identity: 11% PDB header:dna binding protein Chain: A: PDB Molecule:zinc finger homeobox protein 1b; PDBTitle: solution structure of the homeobox domain of zinc finger2 homeobox protein 1b (smad interacting protein 1) Phyre2 PDB 1mjd chain A Region: 175 - 247 Aligned: 73 Modelled: 73 Confidence: 12.4% Identity: 14% Fold: beta-Grasp (ubiquitin-like) Superfamily: Doublecortin (DC) Family: Doublecortin (DC) Phyre2 PDB 5mga chain A Region: 219 - 237 Aligned: 19 Modelled: 19 Confidence: 12.4% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:crispr-associated endonuclease cpf1; PDBTitle: structure of the cpf1 endonuclease r-loop complex after dna cleavage Phyre2 1 c1kcfB_ 2 c5j3bB_ 3 c5id6A_ 4 c5wqeA_ 5 c5u31A_ 6 c3oyyA_ 7 c3a5zD_ 8 d1ueba3 9 c1uebB_ 10 c1ybyB_ 11 d1x2na1 12 c2oceA_ 13 d1g4ma1 14 c5b43A_ 15 c6iv6A_ 16 d1cf1a1 17 c3f3hA_ 18 c2da7A_ 19 d1mjda_ 20 c5mgaA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63