1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	T	H	N	D	S	A	P	T	S	R	R	R	H	I	V	R	L	V	V	F	A	G	F	L	V	G	M	F	Y	L	V	A	A	T	D	V	I	D	V	A	A	V	R	G	A	V	S	A	T	G	P	A	A	P	L	T	Y	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?																												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	V	S	A	V	L	G	A	L	F	V	P	G	P	I	L	A	A	S	S	G	L	L	F	G	P	L	V	G	V	F	V	T	L	G	A	T	V	G	T	A	V	V	A	S	L	V	G	R	R	A	G	R	A	S	A	R	A	L	L
Secondary structure
SS confidence
Disorder											?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	G	E	R	A	D	R	T	D	A	L	I	E	R	C	G	L	W	A	V	V	G	Q	R	F	V	P	G	I	S	D	A	F	A	S	Y	A	F	G	T	F	G	V	P	L	W	Q	M	A	V	G	A	F	I	G	S	A	P	R	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	A	Y	T	A	L	G	A	A	I	G	D	R	S	P	L	L	A	S	C	A	I	A	V	W	C	V	T	A	I	I	G	A	F	A	A	R	H	G	Y	R	Q	W	R	A	H	A	R	G	D	G	A	D	G	G	V	E	D	P	D
Secondary structure
SS confidence
Disorder													?	?		?	?																													?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.
Sequence		R	E	V	G	A	R
Secondary structure
SS confidence
Disorder				?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 80%) Beta strand ( 0%) TM helix ( 57%) (View membrane topology prediction)

Rank Aligned region

PDB 5d7t chain C Region: 72 - 190 Aligned: 119 Modelled: 119 Confidence: 90.5% Identity: 14% PDB header:transport protein Chain: C: PDB Molecule:s-component for folate; PDBTitle: folate ecf transporter: apo state Phyre2 PDB 4huq chain S Region: 72 - 104 Aligned: 33 Modelled: 33 Confidence: 87.2% Identity: 18% PDB header:hydrolase Chain: S: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a transporter Phyre2 PDB 4z7f chain D Region: 72 - 186 Aligned: 110 Modelled: 110 Confidence: 76.5% Identity: 11% PDB header:transport protein Chain: D: PDB Molecule:folate ecf transporter; PDBTitle: crystal structure of folt bound with folic acid Phyre2 PDB 3p5n chain A Region: 72 - 103 Aligned: 32 Modelled: 32 Confidence: 63.9% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:riboflavin uptake protein; PDBTitle: structure and mechanism of the s component of a bacterial ecf2 transporter Phyre2 PDB 6nbx chain G Region: 186 - 242 Aligned: 57 Modelled: 57 Confidence: 43.0% Identity: 18% PDB header:oxidoreductase Chain: G: PDB Molecule:nadh-quinone oxidoreductase subunit j; PDBTitle: t.elongatus ndh (data-set 2) Phyre2 PDB 1cii chain A Region: 123 - 192 Aligned: 65 Modelled: 70 Confidence: 32.9% Identity: 11% PDB header:transmembrane protein Chain: A: PDB Molecule:colicin ia; PDBTitle: colicin ia Phyre2 PDB 3nd0 chain A Region: 12 - 130 Aligned: 119 Modelled: 119 Confidence: 27.9% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:sll0855 protein; PDBTitle: x-ray crystal structure of a slow cyanobacterial cl-/h+ antiporter Phyre2 PDB 5n9y chain B Region: 165 - 224 Aligned: 59 Modelled: 60 Confidence: 26.8% Identity: 12% PDB header:membrane protein Chain: B: PDB Molecule:zinc transport protein zntb; PDBTitle: the full-length structure of zntb Phyre2 PDB 1ots chain A Region: 9 - 130 Aligned: 122 Modelled: 122 Confidence: 26.4% Identity: 18% Fold: Clc chloride channel Superfamily: Clc chloride channel Family: Clc chloride channel Phyre2 PDB 4dve chain A Region: 6 - 160 Aligned: 141 Modelled: 141 Confidence: 26.1% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:biotin transporter bioy; PDBTitle: crystal structure at 2.1 a of the s-component for biotin from an ecf-2 type abc transporter Phyre2 PDB 6hum chain B Region: 16 - 162 Aligned: 147 Modelled: 147 Confidence: 22.3% Identity: 11% PDB header:proton transport Chain: B: PDB Molecule:nad(p)h-quinone oxidoreductase subunit 2; PDBTitle: structure of the photosynthetic complex i from thermosynechococcus2 elongatus Phyre2 PDB 4ezd chain B Region: 40 - 108 Aligned: 69 Modelled: 69 Confidence: 19.4% Identity: 19% PDB header:transport protein Chain: B: PDB Molecule:urea transporter 1; PDBTitle: crystal structure of the ut-b urea transporter from bos taurus bound2 to selenourea Phyre2 PDB 4ev6 chain E Region: 165 - 224 Aligned: 59 Modelled: 60 Confidence: 17.2% Identity: 7% PDB header:metal transport Chain: E: PDB Molecule:magnesium transport protein cora; PDBTitle: the complete structure of cora magnesium transporter from2 methanocaldococcus jannaschii Phyre2 PDB 4m5b chain A Region: 20 - 103 Aligned: 83 Modelled: 84 Confidence: 16.7% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:cobalamin biosynthesis protein cbim; PDBTitle: crystal structure of an truncated transition metal transporter Phyre2 PDB 2b2h chain A Region: 58 - 239 Aligned: 178 Modelled: 182 Confidence: 16.4% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:ammonium transporter; PDBTitle: ammonium transporter amt-1 from a. fulgidus (as) Phyre2 PDB 4m5c chain A Region: 20 - 103 Aligned: 83 Modelled: 84 Confidence: 16.3% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:cobalamin biosynthesis protein cbim; PDBTitle: crystal structure of an truncated transition metal transporter Phyre2 PDB 2n28 chain A Region: 200 - 242 Aligned: 43 Modelled: 43 Confidence: 13.2% Identity: 19% PDB header:viral protein Chain: A: PDB Molecule:protein vpu; PDBTitle: solid-state nmr structure of vpu Phyre2 PDB 6hqe chain U Region: 236 - 243 Aligned: 8 Modelled: 8 Confidence: 12.7% Identity: 75% PDB header:protein fibril Chain: U: PDB Molecule:peptide lrv_m3delta1; PDBTitle: cryo-em of self-assembly peptide filament lrv_m3delta1 Phyre2 PDB 6hqe chain Q Region: 236 - 243 Aligned: 8 Modelled: 8 Confidence: 12.7% Identity: 75% PDB header:protein fibril Chain: Q: PDB Molecule:peptide lrv_m3delta1; PDBTitle: cryo-em of self-assembly peptide filament lrv_m3delta1 Phyre2 PDB 6hqe chain U Region: 236 - 243 Aligned: 8 Modelled: 8 Confidence: 12.7% Identity: 75% PDB header:protein fibril Chain: U: PDB Molecule:peptide lrv_m3delta1; PDBTitle: cryo-em of self-assembly peptide filament lrv_m3delta1 Phyre2 1 c5d7tC_ 2 c4huqS_ 3 c4z7fD_ 4 c3p5nA_ 5 c6nbxG_ 6 c1ciiA_ 7 c3nd0A_ 8 c5n9yB_ 9 d1otsa_ 10 c4dveA_ 11 c6humB_ 12 c4ezdB_ 13 c4ev6E_ 14 c4m5bA_ 15 c2b2hA_ 16 c4m5cA_ 17 c2n28A_ 18 c6hqeu_ 19 c6hqeQ_ 20 c6hqeU_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74