1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	A	A	A	T	T	T	G	T	H	R	G	L	E	L	R	A	A	Q	R	A	V	G	S	C	E	P	Q	R	A	E	F	C	R	S	A	R	N	A	D	E	F	D	Q	M	S	R	M	F	G	D	V	Y	P	D	V	P	V	P	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?											?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	V	W	R	W	I	D	S	A	Q	H	R	L	A	R	A	G	A	V	G	A	L	S	V	V	D	L	L	I	C	D	T	A	A	A	R	G	L	V	V	L	H	D	D	A	D	Y	E	L	A	E	R	H	L	P	D	I	R	V	R
Secondary structure
SS confidence
Disorder																		?	?																																									?
Disorder confidence
		.	.	.	.	.	.	.
Sequence		R	V	V	S	A	D	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 61%) Beta strand ( 6%)

Rank Aligned region

PDB 3h87 chain B Region: 6 - 123 Aligned: 117 Modelled: 118 Confidence: 99.9% Identity: 22% PDB header:toxin/antitoxin Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: rv0301 rv0300 toxin antitoxin complex from mycobacterium tuberculosis Phyre2 PDB 5sv2 chain A Region: 6 - 125 Aligned: 118 Modelled: 120 Confidence: 99.9% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease vapc21; PDBTitle: toxin vapc21 from mycobacterium tuberculosis Phyre2 PDB 4chg chain C Region: 5 - 120 Aligned: 114 Modelled: 116 Confidence: 99.8% Identity: 20% PDB header:toxin/antitoxin Chain: C: PDB Molecule:probable ribonuclease vapc15; PDBTitle: crystal structure of vapbc15 complex from mycobacterium tuberculosis Phyre2 PDB 1y82 chain A domain 1 Region: 3 - 122 Aligned: 115 Modelled: 118 Confidence: 99.8% Identity: 18% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 1v96 chain A domain 1 Region: 11 - 113 Aligned: 100 Modelled: 103 Confidence: 99.7% Identity: 18% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 3dbo chain B Region: 13 - 122 Aligned: 107 Modelled: 110 Confidence: 99.7% Identity: 23% PDB header:toxin/antitoxin Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a member of the vapbc family of toxin-antitoxin2 systems, vapbc-5, from mycobacterium tuberculosis Phyre2 PDB 3zvk chain C Region: 4 - 122 Aligned: 113 Modelled: 119 Confidence: 99.6% Identity: 14% PDB header:antitoxin/toxin/dna Chain: C: PDB Molecule:toxin of toxin-antitoxin system; PDBTitle: crystal structure of vapbc2 from rickettsia felis bound to2 a dna fragment from their promoter Phyre2 PDB 3tnd chain C Region: 15 - 122 Aligned: 102 Modelled: 108 Confidence: 99.6% Identity: 16% PDB header:translation, toxin Chain: C: PDB Molecule:trna(fmet)-specific endonuclease vapc; PDBTitle: crystal structure of shigella flexneri vapbc toxin-antitoxin complex Phyre2 PDB 6nkl chain A Region: 3 - 122 Aligned: 114 Modelled: 116 Confidence: 99.6% Identity: 11% PDB header:antitoxin Chain: A: PDB Molecule:ribonuclease vapc; PDBTitle: 2.2 a resolution structure of vapbc-1 from nontypeable haemophilus2 influenzae Phyre2 PDB 6a7v chain G Region: 3 - 123 Aligned: 119 Modelled: 121 Confidence: 99.6% Identity: 21% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc11; PDBTitle: crystal structure of mycobacterium tuberculosis vapbc11 toxin-2 antitoxin complex Phyre2 PDB 5l6m chain C Region: 5 - 122 Aligned: 108 Modelled: 118 Confidence: 99.5% Identity: 13% PDB header:hydrolase Chain: C: PDB Molecule:ribonuclease vapc; PDBTitle: structure of caulobacter crescentus vapbc1 (vapb1deltac:vapc1 form) Phyre2 PDB 2h1c chain A domain 1 Region: 3 - 122 Aligned: 114 Modelled: 120 Confidence: 99.4% Identity: 12% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 4xgr chain G Region: 5 - 108 Aligned: 100 Modelled: 100 Confidence: 99.2% Identity: 15% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc30; PDBTitle: crystal structure of addiction module from mycobacterial species Phyre2 PDB 5wzf chain B Region: 4 - 115 Aligned: 108 Modelled: 112 Confidence: 98.5% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:23s rrna-specific endonuclease vapc20; PDBTitle: crystal structure of mycobacterium tuberculosis vapc20 (rv2549c),2 sarcin-ricin loop cleaving toxin Phyre2 PDB 5x3t chain D Region: 4 - 116 Aligned: 109 Modelled: 113 Confidence: 98.5% Identity: 11% PDB header:antitoxin/toxin Chain: D: PDB Molecule:ribonuclease vapc26; PDBTitle: vapbc from mycobacterium tuberculosis Phyre2 PDB 2fe1 chain A Region: 5 - 117 Aligned: 103 Modelled: 113 Confidence: 97.8% Identity: 15% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein pae0151; PDBTitle: crystal structure of pae0151 from pyrobaculum aerophilum Phyre2 PDB 2fe1 chain A domain 1 Region: 5 - 117 Aligned: 103 Modelled: 113 Confidence: 97.8% Identity: 15% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 1w8i chain A Region: 20 - 107 Aligned: 84 Modelled: 88 Confidence: 96.4% Identity: 14% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 3ix7 chain A Region: 12 - 124 Aligned: 96 Modelled: 97 Confidence: 86.6% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ttha0540; PDBTitle: crystal structure of a domain of functionally unknown protein from2 thermus thermophilus hb8 Phyre2 PDB 3i8o chain A Region: 81 - 123 Aligned: 42 Modelled: 43 Confidence: 85.5% Identity: 14% PDB header:rna binding protein Chain: A: PDB Molecule:kh domain-containing protein mj1533; PDBTitle: a domain of a functionally unknown protein from methanocaldococcus2 jannaschii dsm 2661. Phyre2 1 c3h87B_ 2 c5sv2A_ 3 c4chgC_ 4 d1y82a1 5 d1v96a1 6 c3dboB_ 7 c3zvkC_ 8 c3tndC_ 9 c6nklA_ 10 c6a7vG_ 11 c5l6mC_ 12 d2h1ca1 13 c4xgrG_ 14 c5wzfB_ 15 c5x3tD_ 16 c2fe1A_ 17 d2fe1a1 18 d1w8ia_ 19 c3ix7A_ 20 c3i8oA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45