1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	E	A	G	R	A	D	T	V	A	P	S	H	R	W	G	L	G	A	F	L	V	V	E	L	V	F	L	V	A	S	T	S	L	A	V	V	L	T	G	H	G	P	V	S	A	G	V	L	A	L	A	L	A	A	P	T	V	V	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?																													?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	G	L	A	I	L	I	T	R	L	R	G	N	G	L	R	T	D	L	R	L	R	W	S	W	R	G	L	R	L	G	L	M	F	G	F	G	G	M	L	V	T	I	P	A	S	L	V	Y	T	A	I	V	G	P	E	A	N	S	A
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?	?	?	?	?			?																												?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	V	R	I	F	G	G	V	R	A	S	W	P	W	A	L	V	V	F	L	V	V	V	F	V	A	P	L	C	E	E	I	I	Y	R	G	L	L	W	G	A	V	D	R	R	W	G	R	W	A	A	L	V	V	T	T	V	V	F	A
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.
Sequence		L	A	H	L	E	F	A	R	A	P	L	L	V	V	V	A	I	P	I	A	L	A	R	F	Y	S	G	G	L	L	A	S	I	V	T	H	Q	V	T	N	L	L	P	G	I	V	L	L	L	G	L	T	G	A	I	S	L	P
Secondary structure
SS confidence
Disorder																																																					?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 21%) Alpha helix ( 79%) Beta strand ( 0%) TM helix ( 61%) (View membrane topology prediction)

Rank Aligned region

PDB 4cad chain C Region: 19 - 225 Aligned: 194 Modelled: 207 Confidence: 100.0% Identity: 15% PDB header:protein binding Chain: C: PDB Molecule:ras and a-factor converting enzyme 1, rce1; PDBTitle: mechanism of farnesylated caax protein processing by the integral2 membrane protease rce1 Phyre2 PDB 4cad chain F Region: 21 - 225 Aligned: 195 Modelled: 205 Confidence: 100.0% Identity: 16% PDB header:protein binding Chain: F: PDB Molecule:ras and a-factor converting enzyme 1, rce1; PDBTitle: mechanism of farnesylated caax protein processing by the integral2 membrane protease rce1 Phyre2 PDB 3rlb chain B Region: 165 - 227 Aligned: 62 Modelled: 63 Confidence: 10.7% Identity: 23% PDB header:thiamine-binding protein Chain: B: PDB Molecule:thit; PDBTitle: crystal structure at 2.0 a of the s-component for thiamin from an ecf-2 type abc transporter Phyre2 PDB 4hzu chain S Region: 170 - 229 Aligned: 60 Modelled: 60 Confidence: 9.0% Identity: 5% PDB header:hydrolase, transport protein Chain: S: PDB Molecule:predicted membrane protein; PDBTitle: structure of a bacterial energy-coupling factor transporter Phyre2 PDB 3rlb chain A Region: 165 - 227 Aligned: 62 Modelled: 63 Confidence: 8.7% Identity: 23% PDB header:thiamine-binding protein Chain: A: PDB Molecule:thit; PDBTitle: crystal structure at 2.0 a of the s-component for thiamin from an ecf-2 type abc transporter Phyre2 PDB 5wwo chain B Region: 150 - 178 Aligned: 29 Modelled: 29 Confidence: 8.0% Identity: 17% PDB header:rna binding protein Chain: B: PDB Molecule:essential nuclear protein 1; PDBTitle: crystal structure of enp1 Phyre2 PDB 2w8a chain C Region: 52 - 208 Aligned: 150 Modelled: 157 Confidence: 7.0% Identity: 14% PDB header:membrane protein Chain: C: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate Phyre2 1 c4cadC_ 2 c4cadF_ 3 c3rlbB_ 4 c4hzuS_ 5 c3rlbA_ 6 c5wwoB_ 7 c2w8aC_