1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	S	F	R	A	D	D	H	D	V	D	L	A	D	A	W	A	R	R	L	H	I	G	R	S	E	L	L	R	D	A	L	R	R	H	L	A	A	L	A	A	D	Q	D	V	Q	A	Y	T	E	R	P	L	T	D	D	E	N	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																							?										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.
Sequence		L	A	E	I	A	D	W	G	P	A	E	D	W	A	D	W	A	D	A	A	R
Secondary structure
SS confidence
Disorder																				?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 78%) Beta strand ( 0%)

Rank Aligned region

PDB 2bj7 chain A domain 1 Region: 12 - 39 Aligned: 28 Modelled: 28 Confidence: 68.0% Identity: 21% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 2k5j chain B Region: 8 - 39 Aligned: 32 Modelled: 32 Confidence: 67.8% Identity: 22% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein yiif; PDBTitle: solution structure of protein yiif from shigella flexneri2 serotype 5b (strain 8401) . northeast structural genomics3 consortium target sft1 Phyre2 PDB 2bj3 chain D Region: 12 - 39 Aligned: 28 Modelled: 28 Confidence: 57.8% Identity: 21% PDB header:transcription Chain: D: PDB Molecule:nickel responsive regulator; PDBTitle: nikr-apo Phyre2 PDB 2hza chain B domain 1 Region: 13 - 38 Aligned: 26 Modelled: 26 Confidence: 54.7% Identity: 46% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 2hza chain A domain 1 Region: 13 - 44 Aligned: 32 Modelled: 32 Confidence: 54.5% Identity: 44% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 1q5v chain B Region: 12 - 38 Aligned: 27 Modelled: 27 Confidence: 50.6% Identity: 44% PDB header:transcription Chain: B: PDB Molecule:nickel responsive regulator; PDBTitle: apo-nikr Phyre2 PDB 2ca9 chain B Region: 24 - 39 Aligned: 16 Modelled: 16 Confidence: 50.4% Identity: 50% PDB header:transcription Chain: B: PDB Molecule:putative nickel-responsive regulator; PDBTitle: apo-nikr from helicobacter pylori in closed trans-2 conformation Phyre2 PDB 6g1n chain B Region: 15 - 37 Aligned: 23 Modelled: 23 Confidence: 32.5% Identity: 35% PDB header:antitoxin Chain: B: PDB Molecule:antitoxin hicb; PDBTitle: crystal structure of the burkholderia pseudomallei antitoxin hicb Phyre2 PDB 2bye chain A domain 1 Region: 50 - 73 Aligned: 24 Modelled: 24 Confidence: 23.5% Identity: 21% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ras-binding domain, RBD Phyre2 PDB 4p7d chain A Region: 18 - 37 Aligned: 20 Modelled: 20 Confidence: 19.9% Identity: 25% PDB header:toxin Chain: A: PDB Molecule:antitoxin hicb3; PDBTitle: antitoxin hicb3 crystal structure Phyre2 PDB 1cmc chain A Region: 22 - 69 Aligned: 36 Modelled: 48 Confidence: 18.4% Identity: 42% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: Met repressor, MetJ (MetR) Phyre2 PDB 1b4p chain A domain 1 Region: 32 - 69 Aligned: 38 Modelled: 38 Confidence: 10.1% Identity: 18% Fold: GST C-terminal domain-like Superfamily: GST C-terminal domain-like Family: Glutathione S-transferase (GST), C-terminal domain Phyre2 PDB 1rqg chain A domain 2 Region: 20 - 43 Aligned: 24 Modelled: 24 Confidence: 10.1% Identity: 29% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 1irx chain A domain 2 Region: 21 - 51 Aligned: 31 Modelled: 31 Confidence: 9.8% Identity: 13% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 5khq chain B Region: 50 - 72 Aligned: 23 Modelled: 23 Confidence: 9.5% Identity: 26% PDB header:signaling protein Chain: B: PDB Molecule:ras-interacting protein 1; PDBTitle: rasip1 ra domain Phyre2 PDB 1f3v chain A Region: 19 - 51 Aligned: 33 Modelled: 33 Confidence: 9.0% Identity: 42% Fold: Ferredoxin-like Superfamily: TRADD, N-terminal domain Family: TRADD, N-terminal domain Phyre2 PDB 1f7u chain A domain 2 Region: 21 - 43 Aligned: 23 Modelled: 23 Confidence: 8.8% Identity: 26% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 5yrz chain C Region: 15 - 35 Aligned: 21 Modelled: 21 Confidence: 8.5% Identity: 29% PDB header:antitoxin/hydrolase Chain: C: PDB Molecule:hicb; PDBTitle: toxin-antitoxin complex from streptococcus pneumoniae Phyre2 PDB 1iq0 chain A domain 2 Region: 21 - 43 Aligned: 23 Modelled: 23 Confidence: 8.4% Identity: 43% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 2cs4 chain A domain 1 Region: 50 - 69 Aligned: 20 Modelled: 20 Confidence: 8.1% Identity: 40% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ras-binding domain, RBD Phyre2 1 d2bj7a1 2 c2k5jB_ 3 c2bj3D_ 4 d2hzab1 5 d2hzaa1 6 c1q5vB_ 7 c2ca9B_ 8 c6g1nB_ 9 d2byea1 10 c4p7dA_ 11 d1cmca_ 12 d1b4pa1 13 d1rqga2 14 d1irxa2 15 c5khqB_ 16 d1f3va_ 17 d1f7ua2 18 c5yrzC_ 19 d1iq0a2 20 d2cs4a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36