1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	E	G	E	V	G	V	G	L	L	D	T	S	V	F	I	A	R	E	S	G	G	A	I	A	D	L	P	E	R	V	A	L	S	V	M	T	I	G	E	L	Q	L	G	L	L	N	A	G	D	S	A	T	R	S	R	R	A	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?														?		?	?	?	?			?																					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.
Sequence		T	L	A	L	A	R	T	A	D	Q	I	P	V	S	E	A	V	M	I	S	L	A	R	L	V	A	D	C	R	A	A	G	V	R	R	S	V	K	L	T	D	A	L	I	A	A	T	A	E	I	K	V
Secondary structure
SS confidence
Disorder						?																										?	?	?	?	?	?	?	?	?	?								?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 28%) Alpha helix ( 61%) Beta strand ( 8%)

Rank Aligned region

PDB 3dbo chain B Region: 9 - 111 Aligned: 98 Modelled: 103 Confidence: 99.9% Identity: 40% PDB header:toxin/antitoxin Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a member of the vapbc family of toxin-antitoxin2 systems, vapbc-5, from mycobacterium tuberculosis Phyre2 PDB 1v96 chain A domain 1 Region: 10 - 111 Aligned: 94 Modelled: 102 Confidence: 99.8% Identity: 21% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 3h87 chain B Region: 10 - 110 Aligned: 97 Modelled: 101 Confidence: 99.8% Identity: 20% PDB header:toxin/antitoxin Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: rv0301 rv0300 toxin antitoxin complex from mycobacterium tuberculosis Phyre2 PDB 2h1c chain A domain 1 Region: 10 - 111 Aligned: 100 Modelled: 102 Confidence: 99.8% Identity: 29% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 5sv2 chain A Region: 10 - 110 Aligned: 96 Modelled: 101 Confidence: 99.7% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease vapc21; PDBTitle: toxin vapc21 from mycobacterium tuberculosis Phyre2 PDB 1y82 chain A domain 1 Region: 10 - 110 Aligned: 95 Modelled: 101 Confidence: 99.7% Identity: 24% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 3tnd chain C Region: 10 - 111 Aligned: 98 Modelled: 102 Confidence: 99.7% Identity: 18% PDB header:translation, toxin Chain: C: PDB Molecule:trna(fmet)-specific endonuclease vapc; PDBTitle: crystal structure of shigella flexneri vapbc toxin-antitoxin complex Phyre2 PDB 3zvk chain C Region: 7 - 111 Aligned: 101 Modelled: 105 Confidence: 99.6% Identity: 21% PDB header:antitoxin/toxin/dna Chain: C: PDB Molecule:toxin of toxin-antitoxin system; PDBTitle: crystal structure of vapbc2 from rickettsia felis bound to2 a dna fragment from their promoter Phyre2 PDB 6nkl chain A Region: 7 - 111 Aligned: 101 Modelled: 105 Confidence: 99.6% Identity: 20% PDB header:antitoxin Chain: A: PDB Molecule:ribonuclease vapc; PDBTitle: 2.2 a resolution structure of vapbc-1 from nontypeable haemophilus2 influenzae Phyre2 PDB 4chg chain C Region: 10 - 111 Aligned: 96 Modelled: 101 Confidence: 99.6% Identity: 25% PDB header:toxin/antitoxin Chain: C: PDB Molecule:probable ribonuclease vapc15; PDBTitle: crystal structure of vapbc15 complex from mycobacterium tuberculosis Phyre2 PDB 5l6m chain C Region: 10 - 111 Aligned: 97 Modelled: 102 Confidence: 99.6% Identity: 26% PDB header:hydrolase Chain: C: PDB Molecule:ribonuclease vapc; PDBTitle: structure of caulobacter crescentus vapbc1 (vapb1deltac:vapc1 form) Phyre2 PDB 4xgr chain G Region: 8 - 110 Aligned: 98 Modelled: 97 Confidence: 99.5% Identity: 18% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc30; PDBTitle: crystal structure of addiction module from mycobacterial species Phyre2 PDB 6a7v chain G Region: 10 - 111 Aligned: 96 Modelled: 102 Confidence: 99.4% Identity: 25% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc11; PDBTitle: crystal structure of mycobacterium tuberculosis vapbc11 toxin-2 antitoxin complex Phyre2 PDB 5x3t chain D Region: 10 - 109 Aligned: 95 Modelled: 100 Confidence: 99.0% Identity: 19% PDB header:antitoxin/toxin Chain: D: PDB Molecule:ribonuclease vapc26; PDBTitle: vapbc from mycobacterium tuberculosis Phyre2 PDB 5wzf chain B Region: 10 - 109 Aligned: 94 Modelled: 100 Confidence: 98.9% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:23s rrna-specific endonuclease vapc20; PDBTitle: crystal structure of mycobacterium tuberculosis vapc20 (rv2549c),2 sarcin-ricin loop cleaving toxin Phyre2 PDB 2fe1 chain A domain 1 Region: 7 - 109 Aligned: 96 Modelled: 103 Confidence: 98.4% Identity: 18% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 2fe1 chain A Region: 7 - 109 Aligned: 96 Modelled: 103 Confidence: 98.4% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein pae0151; PDBTitle: crystal structure of pae0151 from pyrobaculum aerophilum Phyre2 PDB 3ix7 chain A Region: 5 - 109 Aligned: 90 Modelled: 91 Confidence: 95.3% Identity: 20% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ttha0540; PDBTitle: crystal structure of a domain of functionally unknown protein from2 thermus thermophilus hb8 Phyre2 PDB 2lcq chain A Region: 10 - 109 Aligned: 81 Modelled: 100 Confidence: 90.3% Identity: 21% PDB header:metal binding protein Chain: A: PDB Molecule:putative toxin vapc6; PDBTitle: solution structure of the endonuclease nob1 from p.horikoshii Phyre2 PDB 1o4w chain A Region: 6 - 72 Aligned: 66 Modelled: 67 Confidence: 89.7% Identity: 17% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 1 c3dboB_ 2 d1v96a1 3 c3h87B_ 4 d2h1ca1 5 c5sv2A_ 6 d1y82a1 7 c3tndC_ 8 c3zvkC_ 9 c6nklA_ 10 c4chgC_ 11 c5l6mC_ 12 c4xgrG_ 13 c6a7vG_ 14 c5x3tD_ 15 c5wzfB_ 16 d2fe1a1 17 c2fe1A_ 18 c3ix7A_ 19 c2lcqA_ 20 d1o4wa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37