1

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10

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20

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30

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40

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50

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Sequence

V

T

P

R

T

D

E

G

A

A

A

P

C

L

M

P

D

V

T

M

P

V

K

R

G

D

A

R

G

A

L

G

V

G

P

A

L

F

V

V

S

V

S

S

S

L

V

R

A

R

S

C

R

C

T

A

D

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 49%) Alpha helix ( 0%) Beta strand ( 46%)

Rank Aligned region

PDB 2w9v chain A Region: 34 - 54 Aligned: 21 Modelled: 21 Confidence: 24.3% Identity: 43% PDB header:toxin Chain: A: PDB Molecule:short disintegrin jerdostatin; PDBTitle: solution structure of jerdostatin from trimeresurus2 jerdonii with end c-terminal residues n45g46 deleted Phyre2 PDB 2cdx chain A Region: 14 - 40 Aligned: 27 Modelled: 27 Confidence: 11.6% Identity: 33% Fold: Snake toxin-like Superfamily: Snake toxin-like Family: Snake venom toxins Phyre2 PDB 2mck chain A Region: 16 - 28 Aligned: 13 Modelled: 13 Confidence: 11.4% Identity: 54% PDB header:hydrolase Chain: A: PDB Molecule:polyprotein; PDBTitle: backbone 1h, 13c, and 15n chemical shift assignments for murine2 norovirus cr6 ns1/2 protein Phyre2 PDB 1g9i chain I Region: 51 - 55 Aligned: 5 Modelled: 5 Confidence: 8.9% Identity: 100% PDB header:hydrolase/hydrolase inhibitor Chain: I: PDB Molecule:bowman-birk type trypsin inhibitor; PDBTitle: crystal structure of beta-trysin complex in cyclohexane Phyre2 PDB 1byv chain A Region: 3 - 12 Aligned: 10 Modelled: 10 Confidence: 7.9% Identity: 70% PDB header:hormone/growth factor Chain: A: PDB Molecule:protein (calcitonin); PDBTitle: glycosylated eel calcitonin Phyre2 PDB 5z70 chain B Region: 12 - 26 Aligned: 15 Modelled: 15 Confidence: 7.2% Identity: 53% PDB header:hydrolase Chain: B: PDB Molecule:oleate hydratase; PDBTitle: crystal strucure of oleate hydratase from stenotrophomonas sp. kctc2 12332 Phyre2 PDB 5odo chain A Region: 12 - 26 Aligned: 15 Modelled: 15 Confidence: 6.5% Identity: 33% PDB header:lyase Chain: A: PDB Molecule:isomerase; PDBTitle: crystal structure of the oleate hydratase of rhodococcus erythropolis Phyre2 PDB 5m45 chain I Region: 26 - 54 Aligned: 29 Modelled: 29 Confidence: 6.5% Identity: 34% PDB header:ligase Chain: I: PDB Molecule:acetone carboxylase gamma subunit; PDBTitle: structure of acetone carboxylase purified from xanthobacter2 autotrophicus Phyre2 PDB 2mcd chain A Region: 9 - 28 Aligned: 20 Modelled: 20 Confidence: 6.2% Identity: 45% PDB header:hydrolase Chain: A: PDB Molecule:murine norovirus 1; PDBTitle: backbone 1h, 13c, and 15n chemical shift assignments for murine2 norovirus ns1/2 d94e mutant Phyre2 1 c2w9vA_ 2 d2cdxa_ 3 c2mckA_ 4 c1g9iI_ 5 c1byvA_ 6 c5z70B_ 7 c5odoA_ 8 c5m45I_ 9 c2mcdA_