1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	D	T	H	V	V	T	N	Q	V	P	P	L	E	N	Y	N	P	A	S	S	P	V	L	I	E	A	L	I	Q	E	G	G	Q	W	G	L	D	E	V	N	E	V	G	A	I	S	A	S	C	Q	A	Q	R	W	G	E	L	A
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	R	N	R	P	I	L	H	T	H	D	A	Y	G	Y	R	V	D	E	V	E	Y	D	P	A	Y	H	E	L	M	R	T	A	I	T	H	G	M	H	A	A	P	W	A	D	D	R	P	G	A	H	V	V	R	A	A	K	T	S	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		W	T	V	E	P	G	H	I	C	P	I	S	M	T	Y	A	V	V	P	A	L	R	Y	N	S	E	L	A	A	V	Y	E	P	L	L	T	S	R	E	Y	D	P	E	L	K	P	A	T	T	K	A	G	I	T	A	G	M	S	M	T
Secondary structure
SS confidence
Disorder										?	?												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	K	Q	G	G	S	D	V	R	A	G	T	T	Q	A	T	P	N	A	D	G	S	Y	S	L	T	G	H	K	W	F	T	S	A	P	M	C	D	I	F	L	V	L	A	Q	A	P	D	G	L	S	C	F	L	L	P	R	V	L	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		D	G	T	R	N	R	M	F	L	Q	R	L	K	D	K	L	G	N	H	A	N	A	S	S	E	V	E	Y	D	G	A	V	A	W	L	V	G	E	E	G	R	G	V	P	T	I	I	E	M	V	N	L	T	R	L	D	C	A	L	G
Secondary structure
SS confidence
Disorder									?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	A	T	S	M	R	T	G	L	T	R	A	V	H	H	A	Q	H	R	K	A	F	G	A	Y	L	I	D	Q	P	L	M	R	N	V	L	A	D	L	A	V	E	A	E	A	A	T	I	V	A	M	R	M	A	G	A	T	D	N	A
Secondary structure
SS confidence
Disorder																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	R	G	N	E	T	E	A	L	L	R	R	I	G	L	A	A	A	K	Y	W	V	C	K	R	S	T	A	H	A	A	E	A	L	E	C	L	G	G	N	G	Y	V	E	D	S	G	M	P	R	L	Y	R	E	A	P	L	M	G	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		W	E	G	S	G	N	V	S	A	L	D	T	L	R	A	M	A	T	R	P	A	C	V	E	V	L	F	D	E	L	A	R	S	A	G	Q	D	P	R	L	D	G	H	V	E	R	L	R	P	Q	L	G	D	L	D	T	I	G	Y	R
Secondary structure
SS confidence
Disorder																	?		?	?	?	?												?	?	?	?	?	?	?	?	?											?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		A	R	K	I	A	E	D	I	C	L	A	L	Q	G	S	L	L	V	R	H	G	H	P	A	V	A	E	A	F	L	A	T	R	L	G	G	Q	W	G	G	A	Y	G	T	M	P	A	G	L	D	L	A	P	I	L	E	R	A	L	V
Secondary structure
SS confidence
Disorder																																																?										?	?	?	?
Disorder confidence
		.	.
Sequence		K	G
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 60%) Beta strand ( 10%) TM helix ( 11%) (View membrane topology prediction)

Rank Aligned region

PDB 5ez3 chain B Region: 3 - 541 Aligned: 536 Modelled: 539 Confidence: 100.0% Identity: 46% PDB header:oxidoreductase Chain: B: PDB Molecule:acyl-coa dehydrogenase; PDBTitle: crystal structure acyl-coa dehydrogenase from brucella melitensis in2 complex with fad Phyre2 PDB 3djl chain A Region: 3 - 540 Aligned: 530 Modelled: 538 Confidence: 100.0% Identity: 42% PDB header:oxidoreductase Chain: A: PDB Molecule:protein aidb; PDBTitle: crystal structure of alkylation response protein e. coli aidb Phyre2 PDB 4y9l chain B Region: 2 - 519 Aligned: 507 Modelled: 518 Confidence: 100.0% Identity: 30% PDB header:oxidoreductase Chain: B: PDB Molecule:protein acdh-11, isoform b; PDBTitle: crystal structure of caenorhabditis elegans acdh-11 Phyre2 PDB 6ijc chain A Region: 18 - 540 Aligned: 493 Modelled: 510 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coa dehydrogenase family protein; PDBTitle: structure of mmpa-coa dehydrogenase from roseovarius nubinhibens ism Phyre2 PDB 3owa chain C Region: 38 - 538 Aligned: 449 Modelled: 470 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: C: PDB Molecule:acyl-coa dehydrogenase; PDBTitle: crystal structure of acyl-coa dehydrogenase complexed with fad from2 bacillus anthracis Phyre2 PDB 2z1q chain A Region: 38 - 518 Aligned: 447 Modelled: 457 Confidence: 100.0% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coa dehydrogenase; PDBTitle: crystal structure of acyl coa dehydrogenase Phyre2 PDB 2uxw chain A Region: 28 - 538 Aligned: 462 Modelled: 491 Confidence: 100.0% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:very-long-chain specific acyl-coa dehydrogenase; PDBTitle: crystal structure of human very long chain acyl-coa dehydrogenase2 (acadvl) Phyre2 PDB 6es9 chain A Region: 30 - 437 Aligned: 369 Modelled: 378 Confidence: 100.0% Identity: 22% PDB header:flavoprotein Chain: A: PDB Molecule:acyl-coa dehydrogenase; PDBTitle: methylsuccinyl-coa dehydrogenase of paracoccus denitrificans with2 bound flavin adenine dinucleotide Phyre2 PDB 2ix5 chain A Region: 1 - 438 Aligned: 395 Modelled: 401 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coenzyme a oxidase 4, peroxisomal; PDBTitle: short chain specific acyl-coa oxidase from arabidopsis thaliana, acx42 in complex with acetoacetyl-coa Phyre2 PDB 4hr3 chain A Region: 32 - 439 Aligned: 387 Modelled: 395 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:putative acyl-coa dehydrogenase; PDBTitle: structure of a putative acyl-coa dehydrogenase from mycobacterium2 abscessus Phyre2 PDB 5y9d chain A Region: 17 - 438 Aligned: 403 Modelled: 421 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coenzyme a oxidase 1; PDBTitle: crystal structure of acyl-coa oxidase1 from yarrowia lipolytica Phyre2 PDB 1w07 chain A Region: 87 - 438 Aligned: 338 Modelled: 335 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coa oxidase; PDBTitle: arabidopsis thaliana acyl-coa oxidase 1 Phyre2 PDB 2fon chain A Region: 51 - 438 Aligned: 364 Modelled: 372 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:peroxisomal acyl-coa oxidase 1a; PDBTitle: x-ray crystal structure of leacx1, an acyl-coa oxidase from2 lycopersicon esculentum (tomato) Phyre2 PDB 5k3i chain H Region: 13 - 438 Aligned: 406 Modelled: 413 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: H: PDB Molecule:acyl-coenzyme a oxidase; PDBTitle: crystal structure of acyl-coa oxidase-1 in caenorhabditis elegans2 complexed with fad and atp Phyre2 PDB 5ys9 chain A Region: 17 - 438 Aligned: 399 Modelled: 411 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coenzyme a oxidase 3; PDBTitle: crystal structure of acyl-coa oxidase3 from yarrowia lipolytica Phyre2 PDB 5k3j chain A Region: 21 - 438 Aligned: 395 Modelled: 405 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coenzyme a oxidase; PDBTitle: crystals structure of acyl-coa oxidase-2 in caenorhabditis elegans2 bound with fad, ascaroside-coa, and atp Phyre2 PDB 5zw2 chain A Region: 87 - 439 Aligned: 340 Modelled: 353 Confidence: 100.0% Identity: 17% PDB header:biosynthetic protein Chain: A: PDB Molecule:l-prolyl-[peptidyl-carrier protein] dehydrogenase; PDBTitle: fad complex of piga Phyre2 PDB 1rx0 chain B Region: 13 - 439 Aligned: 379 Modelled: 393 Confidence: 100.0% Identity: 20% PDB header:oxidoreductase Chain: B: PDB Molecule:acyl-coa dehydrogenase family member 8, mitochondrial; PDBTitle: crystal structure of isobutyryl-coa dehydrogenase complexed with2 substrate/ligand. Phyre2 PDB 2ddh chain A Region: 87 - 438 Aligned: 332 Modelled: 338 Confidence: 100.0% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coa oxidase; PDBTitle: crystal structure of acyl-coa oxidase complexed with 3-oh-dodecanoate Phyre2 PDB 1ivh chain D Region: 69 - 439 Aligned: 356 Modelled: 365 Confidence: 100.0% Identity: 21% PDB header:oxidoreductase Chain: D: PDB Molecule:isovaleryl-coa dehydrogenase; PDBTitle: structure of human isovaleryl-coa dehydrogenase at 2.62 angstroms resolution: structural basis for substrate3 specificity Phyre2 1 c5ez3B_ 2 c3djlA_ 3 c4y9lB_ 4 c6ijcA_ 5 c3owaC_ 6 c2z1qA_ 7 c2uxwA_ 8 c6es9A_ 9 c2ix5A_ 10 c4hr3A_ 11 c5y9dA_ 12 c1w07A_ 13 c2fonA_ 14 c5k3iH_ 15 c5ys9A_ 16 c5k3jA_ 17 c5zw2A_ 18 c1rx0B_ 19 c2ddhA_ 20 c1ivhD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105