1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	G	T	E	H	L	V	H	T	L	R	S	Q	G	R	V	C	T	S	S	G	S	P	M	Y	R	E	L	L	E	L	V	A	A	D	V	E	S	G	G	V	F	A	S	I	L	A	D	Q	K	G	A	P	E	G	Q	A	V	P
Secondary structure
SS confidence
Disorder		?	?	?																																				?														?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	R	L	L	G	G	L	H	R	M	V	L	D	G	R	A	P	V	L	R	R	W	Y	P	S	T	G	G	T	W	Q	A	E	A	A	W	P	D	I	V	R	T	A	T	D	Q	P	E	S	L	R	A	A	L	D	R	P	P	Q	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		N	E	V	G	R	S	A	A	L	I	G	G	L	L	I	A	C	L	Q	F	D	L	P	I	R	L	F	E	I	G	S	S	A	G	L	N	L	R	P	D	R	Y	R	Y	R	Y	L	G	G	E	W	G	L	A	D	S	P	V	R	I
Secondary structure
SS confidence
Disorder																				?																															?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	N	A	W	L	G	E	L	P	P	T	A	T	V	R	I	V	E	R	H	G	Y	D	I	A	P	I	D	V	T	S	P	D	G	E	L	N	A	L	S	Y	I	W	P	D	Q	T	D	R	L	E	R	L	R	G	A	I	A	V	A
Secondary structure
SS confidence
Disorder				?			?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	N	I	P	A	D	L	H	R	Q	A	A	H	A	A	V	A	G	M	T	L	T	D	D	A	L	T	V	L	W	H	S	I	T	W	Q	Y	L	P	A	D	E	R	A	A	I	R	A	G	I	D	A	L	A	A	Q	A	D	A	H
Secondary structure
SS confidence
Disorder			?	?	?															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.
Sequence		C	P	F	V	H	L	T	L	E	P	A	H	Q	R	P	G	A	Q	I	K	Y	L	V	R	M	R	S	W	P	G	G	H	A	R	V	L	G	E	C	H	P	H	G	P	P	V	T	W	Q
Secondary structure
SS confidence
Disorder													?	?	?	?	?																															?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 44%) Beta strand ( 10%)

Rank Aligned region

PDB 5dpl chain B Region: 145 - 292 Aligned: 93 Modelled: 99 Confidence: 72.9% Identity: 17% PDB header:transferase Chain: B: PDB Molecule:protein lysine methyltransferase 2; PDBTitle: the structure of pkmt2 from rickettsia typhi in complex with adohcy Phyre2 PDB 6cn0 chain B Region: 4 - 156 Aligned: 124 Modelled: 142 Confidence: 70.0% Identity: 17% PDB header:transferase Chain: B: PDB Molecule:16s rrna (guanine(1405)-n(7))-methyltransferase; PDBTitle: 2.95 angstrom crystal structure of 16s rrna methylase from proteus2 mirabilis Phyre2 PDB 5do0 chain A Region: 118 - 293 Aligned: 119 Modelled: 125 Confidence: 56.4% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:protein lysine methyltransferase 1; PDBTitle: the structure of pkmt1 from rickettsia prowazekii Phyre2 PDB 5mpt chain A Region: 71 - 154 Aligned: 64 Modelled: 64 Confidence: 50.0% Identity: 28% PDB header:transferase Chain: A: PDB Molecule:citrinin polyketide synthase; PDBTitle: structure of the citrinin polyketide synthase cmet domain Phyre2 PDB 1af7 chain A domain 2 Region: 130 - 154 Aligned: 25 Modelled: 25 Confidence: 45.2% Identity: 16% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Chemotaxis receptor methyltransferase CheR, C-terminal domain Phyre2 PDB 3tfw chain B Region: 96 - 155 Aligned: 60 Modelled: 60 Confidence: 30.7% Identity: 18% PDB header:transferase Chain: B: PDB Molecule:putative o-methyltransferase; PDBTitle: crystal structure of a putative o-methyltransferase from klebsiella2 pneumoniae Phyre2 PDB 3fzg chain A Region: 96 - 157 Aligned: 60 Modelled: 62 Confidence: 23.9% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:16s rrna methylase; PDBTitle: structure of the 16s rrna methylase arma Phyre2 PDB 5n5d chain A Region: 93 - 154 Aligned: 62 Modelled: 62 Confidence: 23.8% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:methyltransferase; PDBTitle: crystal structure of the o-methyltransferase tomg from streptomyces2 achromogenes involved in tomaymycin synthesis in complex with sam Phyre2 PDB 1kyz chain A domain 2 Region: 96 - 154 Aligned: 59 Modelled: 59 Confidence: 22.9% Identity: 19% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Plant O-methyltransferase, C-terminal domain Phyre2 PDB 1ogm chain X domain 1 Region: 147 - 182 Aligned: 35 Modelled: 36 Confidence: 22.5% Identity: 31% Fold: Dextranase, N-terminal domain Superfamily: Dextranase, N-terminal domain Family: Dextranase, N-terminal domain Phyre2 PDB 1fye chain A Region: 149 - 269 Aligned: 80 Modelled: 98 Confidence: 22.0% Identity: 25% Fold: Flavodoxin-like Superfamily: Class I glutamine amidotransferase-like Family: Aspartyl dipeptidase PepE Phyre2 PDB 1qt1 chain A Region: 203 - 315 Aligned: 93 Modelled: 93 Confidence: 21.9% Identity: 20% Fold: TIM beta/alpha-barrel Superfamily: Xylose isomerase-like Family: Xylose isomerase Phyre2 PDB 2yr0 chain A Region: 126 - 157 Aligned: 32 Modelled: 32 Confidence: 21.5% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:hypothetical protein ttha0223; PDBTitle: crystal structure of hypothetical methyltransferase ttha0223 from2 thermus thermophilus hb8 Phyre2 PDB 2ys9 chain A Region: 78 - 123 Aligned: 44 Modelled: 46 Confidence: 20.1% Identity: 23% PDB header:transcription Chain: A: PDB Molecule:homeobox and leucine zipper protein homez; PDBTitle: structure of the third homeodomain from the human homeobox2 and leucine zipper protein, homez Phyre2 PDB 5xlx chain D Region: 135 - 154 Aligned: 20 Modelled: 20 Confidence: 19.1% Identity: 15% PDB header:transferase Chain: D: PDB Molecule:chemotaxis protein methyltransferase 1; PDBTitle: crystal structure of the c-terminal domain of cher1 containing sah Phyre2 PDB 3ssm chain B Region: 80 - 162 Aligned: 83 Modelled: 83 Confidence: 17.8% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:methyltransferase; PDBTitle: myce methyltransferase from the mycinamycin biosynthetic pathway in2 complex with mg and sah, crystal form 1 Phyre2 PDB 2bm8 chain A domain 1 Region: 127 - 154 Aligned: 24 Modelled: 28 Confidence: 16.5% Identity: 29% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: CmcI-like Phyre2 PDB 4azs chain A Region: 112 - 155 Aligned: 44 Modelled: 44 Confidence: 16.3% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:methyltransferase wbdd; PDBTitle: high resolution (2.2 a) crystal structure of wbdd. Phyre2 PDB 5ufm chain B Region: 131 - 157 Aligned: 27 Modelled: 27 Confidence: 16.1% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:methyltransferase domain protein; PDBTitle: crystal structure of burkholderia thailandensis 1,6-2 didemethyltoxoflavin-n1-methyltransferase with bound 1,6-3 didemethyltoxoflavin and s-adenosylhomocysteine Phyre2 PDB 2gsl chain E Region: 250 - 290 Aligned: 41 Modelled: 41 Confidence: 15.2% Identity: 12% PDB header:structural genomics, unknown function Chain: E: PDB Molecule:hypothetical protein; PDBTitle: x-ray crystal structure of protein fn1578 from fusobacterium2 nucleatum. northeast structural genomics consortium target nr1. Phyre2 1 c5dplB_ 2 c6cn0B_ 3 c5do0A_ 4 c5mptA_ 5 d1af7a2 6 c3tfwB_ 7 c3fzgA_ 8 c5n5dA_ 9 d1kyza2 10 d1ogmx1 11 d1fyea_ 12 d1qt1a_ 13 c2yr0A_ 14 c2ys9A_ 15 c5xlxD_ 16 c3ssmB_ 17 d2bm8a1 18 c4azsA_ 19 c5ufmB_ 20 c2gslE_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61