1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	G	R	R	G	N	R	R	V	H	V	D	R	V	R	L	T	G	T	E	R	E	L	R	A	E	N	Q	S	P	P	I	F	R	P	Q	N	T	L	G	D	G	A	N	G	L	P	L	A	V	C	T	T	T	A	H	T	C	H	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?												?	?	?	?	?	?	?	?												?		?	?												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	H	T	H	P	S	R	W	T	P	N	P	V	P	A	T	K	G	V	P	A	G	L	V	Q	A	T	F	I	I	E	N	L	D	P	G	N	N	D	T	P	T	P	P	T	P	K	L	R	L	A	R	K	P	G	H	H	R	R	S
Secondary structure
SS confidence
Disorder						?									?	?	?	?																				?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	Y	D	A	D	S	V	L	R	R	K	D	T	S	R	R	C	V	Q	A	D	D	V	R	C	V	Q	L	V	Q	D	P	R	R	G	R	V	E	L	G	G	Y	R	A	E	L	T	V	G	R	R	A	A	V	N	C	Q	R	P	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?				?	?	?		?		?	?	?																				?	?											?	?	?	?	?				?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.
Sequence		Y	G	A	D	G	W	P	V	R	L	G	C	G	V	G	G	A	A	R	G	D	Q	R
Secondary structure
SS confidence
Disorder			?	?	?												?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 39%) Alpha helix ( 8%) Beta strand ( 34%)

Rank Aligned region

PDB 2oxt chain C Region: 185 - 196 Aligned: 12 Modelled: 12 Confidence: 16.4% Identity: 67% PDB header:viral protein Chain: C: PDB Molecule:nucleoside-2'-o-methyltransferase; PDBTitle: crystal structure of meaban virus nucleoside-2'-o-2 methyltransferase Phyre2 PDB 3ely chain A Region: 178 - 196 Aligned: 19 Modelled: 19 Confidence: 15.5% Identity: 42% PDB header:transferase Chain: A: PDB Molecule:methyltransferase; PDBTitle: wesselsbron virus methyltransferase in complex with adohcy Phyre2 PDB 3nfg chain G Region: 115 - 170 Aligned: 45 Modelled: 56 Confidence: 9.7% Identity: 29% PDB header:transcription Chain: G: PDB Molecule:dna-directed rna polymerase i subunit rpa49; PDBTitle: crystal structure of dimerization module of rna polymerase i2 subcomplex a49/a34.5 Phyre2 PDB 5ccv chain H Region: 185 - 196 Aligned: 12 Modelled: 12 Confidence: 9.5% Identity: 58% PDB header:transferase Chain: H: PDB Molecule:rna-directed rna polymerase ns5; PDBTitle: crystal structure of full-length ns5 from dengue virus type 3 Phyre2 PDB 1ed7 chain A Region: 57 - 75 Aligned: 19 Modelled: 19 Confidence: 9.5% Identity: 42% Fold: WW domain-like Superfamily: Carbohydrate binding domain Family: Carbohydrate binding domain Phyre2 PDB 4f7o chain B Region: 139 - 164 Aligned: 26 Modelled: 26 Confidence: 9.3% Identity: 38% PDB header:hydrolase Chain: B: PDB Molecule:cop9 signalosome complex subunit 5; PDBTitle: crystal structure of csn5 Phyre2 PDB 2j8a chain A Region: 20 - 52 Aligned: 33 Modelled: 33 Confidence: 9.0% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:histone-lysine n-methyltransferase, h3 lysine-4 PDBTitle: x-ray structure of the n-terminus rrm domain of set1 Phyre2 PDB 3u2a chain A Region: 12 - 23 Aligned: 12 Modelled: 12 Confidence: 9.0% Identity: 58% PDB header:hydrolase Chain: A: PDB Molecule:ggdef family protein; PDBTitle: adaptor dependent degradation of a cell-cycle regulator reveals2 diversity in substrate architectures Phyre2 PDB 1yua chain A domain 1 Region: 37 - 52 Aligned: 16 Modelled: 16 Confidence: 8.9% Identity: 50% Fold: Rubredoxin-like Superfamily: Zinc beta-ribbon Family: Prokaryotic DNA topoisomerase I, a C-terminal fragment Phyre2 PDB 1tff chain A Region: 81 - 116 Aligned: 34 Modelled: 36 Confidence: 8.4% Identity: 24% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Ubiquitin thiolesterase protein OTUB2 (Otubain-2) Phyre2 PDB 6g4w chain W Region: 63 - 71 Aligned: 9 Modelled: 9 Confidence: 8.0% Identity: 44% PDB header:ribosome Chain: W: PDB Molecule:40s ribosomal protein s15a; PDBTitle: cryo-em structure of a late human pre-40s ribosomal subunit - state a Phyre2 PDB 5wwo chain B Region: 63 - 71 Aligned: 9 Modelled: 9 Confidence: 7.8% Identity: 44% PDB header:rna binding protein Chain: B: PDB Molecule:essential nuclear protein 1; PDBTitle: crystal structure of enp1 Phyre2 PDB 5tfr chain A Region: 185 - 196 Aligned: 12 Modelled: 12 Confidence: 7.7% Identity: 67% PDB header:viral protein Chain: A: PDB Molecule:genome polyprotein; PDBTitle: crystal structure of zika virus ns5 protein Phyre2 PDB 4k6m chain A Region: 185 - 196 Aligned: 12 Modelled: 12 Confidence: 7.5% Identity: 58% PDB header:transferase Chain: A: PDB Molecule:polyprotein; PDBTitle: crystal structure of the full-length japanese encephalitis virus ns5 Phyre2 PDB 1yua chain A Region: 37 - 52 Aligned: 16 Modelled: 16 Confidence: 7.4% Identity: 50% PDB header:dna binding protein Chain: A: PDB Molecule:topoisomerase i; PDBTitle: c-terminal domain of escherichia coli topoisomerase i Phyre2 PDB 5o60 chain B Region: 106 - 124 Aligned: 19 Modelled: 19 Confidence: 7.2% Identity: 37% PDB header:ribosome Chain: B: PDB Molecule:5s rrna; PDBTitle: structure of the 50s large ribosomal subunit from mycobacterium2 smegmatis Phyre2 PDB 5m8b chain B Region: 169 - 188 Aligned: 18 Modelled: 20 Confidence: 7.1% Identity: 33% PDB header:hydrolase Chain: B: PDB Molecule:alpha-l-arabinofuranosidase ii; PDBTitle: crystal structure of alpha-l-arabinofuranosidase from lactobacillus2 brevis Phyre2 PDB 1oqe chain O Region: 68 - 75 Aligned: 8 Modelled: 8 Confidence: 7.0% Identity: 63% PDB header:immune system Chain: O: PDB Molecule:tumor necrosis factor receptor superfamily member 13c; PDBTitle: crystal structure of stall-1 with baff-r Phyre2 PDB 1oqe chain R Region: 68 - 75 Aligned: 8 Modelled: 8 Confidence: 7.0% Identity: 63% PDB header:immune system Chain: R: PDB Molecule:tumor necrosis factor receptor superfamily member 13c; PDBTitle: crystal structure of stall-1 with baff-r Phyre2 PDB 1oqe chain P Region: 68 - 75 Aligned: 8 Modelled: 8 Confidence: 7.0% Identity: 63% PDB header:immune system Chain: P: PDB Molecule:tumor necrosis factor receptor superfamily member 13c; PDBTitle: crystal structure of stall-1 with baff-r Phyre2 1 c2oxtC_ 2 c3elyA_ 3 c3nfgG_ 4 c5ccvH_ 5 d1ed7a_ 6 c4f7oB_ 7 c2j8aA_ 8 c3u2aA_ 9 d1yuaa1 10 d1tffa_ 11 c6g4ww_ 12 c5wwoB_ 13 c5tfrA_ 14 c4k6mA_ 15 c1yuaA_ 16 c5o60b_ 17 c5m8bB_ 18 c1oqeO_ 19 c1oqeR_ 20 c1oqeP_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35