1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	P	L	A	R	L	R	G	R	R	V	V	P	Q	R	S	A	G	E	L	D	A	M	A	A	A	G	A	V	V	A	A	A	L	R	A	I	R	A	A	A	A	P	G	T	S	S	L	S	L	D	E	I	A	E	S	V	I	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?			?	?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	S	G	A	T	P	S	F	L	G	Y	H	G	Y	P	A	S	I	C	A	S	I	N	D	R	V	V	H	G	I	P	S	T	A	E	V	L	A	P	G	D	L	V	S	I	D	C	G	A	V	L	D	G	W	H	G	D	A	A	I
Secondary structure
SS confidence
Disorder									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	F	G	V	G	A	L	S	D	A	D	E	A	L	S	E	A	T	R	E	S	L	Q	A	G	I	A	A	M	V	V	G	N	R	L	T	D	V	A	H	A	I	E	T	G	T	R	A	A	E	L	R	Y	G	R	S	F	G	I	V
Secondary structure
SS confidence
Disorder																																																			?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	G	Y	G	G	H	G	I	G	R	Q	M	H	M	D	P	F	L	P	N	E	G	A	P	G	R	G	P	L	L	A	A	G	S	V	L	A	I	E	P	M	L	T	L	G	T	T	K	T	V	V	L	D	D	K	W	T	V	T	T
Secondary structure
SS confidence
Disorder																								?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.
Sequence		A	D	G	S	R	A	A	H	W	E	H	T	V	A	V	T	D	D	G	P	R	I	L	T	L	G
Secondary structure
SS confidence
Disorder																									?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 35%) Beta strand ( 22%)

Rank Aligned region

PDB 4fuk chain B Region: 11 - 264 Aligned: 247 Modelled: 254 Confidence: 100.0% Identity: 35% PDB header:hydrolase Chain: B: PDB Molecule:methionine aminopeptidase; PDBTitle: aminopeptidase from trypanosoma brucei Phyre2 PDB 3tav chain A Region: 7 - 265 Aligned: 259 Modelled: 259 Confidence: 100.0% Identity: 74% PDB header:hydrolase Chain: A: PDB Molecule:methionine aminopeptidase; PDBTitle: crystal structure of a methionine aminopeptidase from mycobacterium2 abscessus Phyre2 PDB 3s6b chain A Region: 6 - 264 Aligned: 252 Modelled: 259 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:methionine aminopeptidase; PDBTitle: crystal structure of methionine aminopeptidase 1b from plasmodium2 falciparum, pf10_0150 Phyre2 PDB 2g6p chain A Region: 7 - 266 Aligned: 253 Modelled: 260 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:methionine aminopeptidase 1; PDBTitle: crystal structure of truncated (delta 1-89) human methionine2 aminopeptidase type 1 in complex with pyridyl pyrimidine derivative Phyre2 PDB 2gz5 chain A Region: 7 - 266 Aligned: 253 Modelled: 260 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:methionine aminopeptidase 1; PDBTitle: human type 1 methionine aminopeptidase in complex with ovalicin at 1.12 ang Phyre2 PDB 1yj3 chain A Region: 11 - 265 Aligned: 248 Modelled: 255 Confidence: 100.0% Identity: 35% PDB header:hydrolase Chain: A: PDB Molecule:methionine aminopeptidase; PDBTitle: crystal structure analysis of product bound methionine aminopeptidase2 type 1c from mycobacterium tuberculosis Phyre2 PDB 2gg2 chain A domain 1 Region: 13 - 264 Aligned: 246 Modelled: 252 Confidence: 100.0% Identity: 38% Fold: Creatinase/aminopeptidase Superfamily: Creatinase/aminopeptidase Family: Creatinase/aminopeptidase Phyre2 PDB 1o0x chain A Region: 12 - 265 Aligned: 248 Modelled: 254 Confidence: 100.0% Identity: 40% Fold: Creatinase/aminopeptidase Superfamily: Creatinase/aminopeptidase Family: Creatinase/aminopeptidase Phyre2 PDB 4fo7 chain B Region: 13 - 266 Aligned: 247 Modelled: 254 Confidence: 100.0% Identity: 37% PDB header:hydrolase Chain: B: PDB Molecule:methionine aminopeptidase; PDBTitle: pseudomonas aeruginosa metap, in mn form Phyre2 PDB 3mx6 chain A Region: 13 - 265 Aligned: 246 Modelled: 253 Confidence: 100.0% Identity: 37% PDB header:hydrolase Chain: A: PDB Molecule:methionine aminopeptidase; PDBTitle: crystal structure of methionine aminopeptidase from rickettsia2 prowazekii bound to methionine Phyre2 PDB 4km3 chain B Region: 12 - 264 Aligned: 237 Modelled: 238 Confidence: 100.0% Identity: 36% PDB header:hydrolase Chain: B: PDB Molecule:methionine aminopeptidase; PDBTitle: discovery of a novel structural motif in methionine aminopeptidase2 from streptococci with possible post-translational modification Phyre2 PDB 1w7v chain D Region: 11 - 266 Aligned: 237 Modelled: 256 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: D: PDB Molecule:xaa-pro aminopeptidase; PDBTitle: znmg substituted aminopeptidase p from e. coli Phyre2 PDB 4qr8 chain B Region: 11 - 264 Aligned: 247 Modelled: 254 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:xaa-pro dipeptidase; PDBTitle: crystal structure of e coli pepq Phyre2 PDB 5wze chain C Region: 10 - 266 Aligned: 241 Modelled: 257 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: C: PDB Molecule:aminopeptidase p; PDBTitle: the structure of pseudomonas aeruginosa aminopeptidase pepp Phyre2 PDB 3l24 chain A Region: 10 - 264 Aligned: 245 Modelled: 255 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:xaa-pro dipeptidase; PDBTitle: crystal structure of the nerve agent degrading2 organophosphate anhydrolase/prolidase in complex with3 inhibitors Phyre2 PDB 1qxy chain A Region: 12 - 264 Aligned: 245 Modelled: 253 Confidence: 100.0% Identity: 32% Fold: Creatinase/aminopeptidase Superfamily: Creatinase/aminopeptidase Family: Creatinase/aminopeptidase Phyre2 PDB 3rva chain A Region: 10 - 264 Aligned: 248 Modelled: 255 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:organophosphorus acid anhydrolase; PDBTitle: crystal structure of organophosphorus acid anhydrolase from2 alteromonas macleodii Phyre2 PDB 5x49 chain A Region: 10 - 266 Aligned: 238 Modelled: 257 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:probable xaa-pro aminopeptidase 3; PDBTitle: crystal structure of human mitochondrial x-prolyl aminopeptidase2 (xpnpep3) Phyre2 PDB 2okn chain B Region: 11 - 264 Aligned: 250 Modelled: 254 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:xaa-pro dipeptidase; PDBTitle: crystal strcture of human prolidase Phyre2 PDB 4r60 chain A Region: 11 - 264 Aligned: 227 Modelled: 232 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:proline dipeptidase; PDBTitle: crystal structure of xaa-pro dipeptidase from xanthomonas campestris Phyre2 1 c4fukB_ 2 c3tavA_ 3 c3s6bA_ 4 c2g6pA_ 5 c2gz5A_ 6 c1yj3A_ 7 d2gg2a1 8 d1o0xa_ 9 c4fo7B_ 10 c3mx6A_ 11 c4km3B_ 12 c1w7vD_ 13 c4qr8B_ 14 c5wzeC_ 15 c3l24A_ 16 d1qxya_ 17 c3rvaA_ 18 c5x49A_ 19 c2oknB_ 20 c4r60A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99