1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	F	S	V	K	G	E	E	G	K	Q	A	L	D	R	W	I	S	W	A	R	R	C	R	I	P	V	F	V	E	L	A	G	G	I	V	R	H	R	Q	A	I	D	A	A	L	D	H	G	L	W	Q	G	L	I	E	S	T	N	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.
Sequence		K	I	R	L	L	T	R	I	A	F	G	F	R	S	P	E	A	L	I	A	L	A	M	L	A	L	G	G	R	R	P	A	L	P	G	R	T	K	H	P	R	I	S	Q
Secondary structure
SS confidence
Disorder																														?	?		?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 66%) Beta strand ( 0%)

Rank Aligned region

PDB 1k6y chain B Region: 39 - 87 Aligned: 49 Modelled: 49 Confidence: 57.4% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of a two-domain fragment of hiv-1 integrase Phyre2 PDB 1hyv chain A Region: 48 - 87 Aligned: 40 Modelled: 40 Confidence: 55.1% Identity: 18% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Retroviral integrase, catalytic domain Phyre2 PDB 3f9k chain V Region: 48 - 87 Aligned: 40 Modelled: 40 Confidence: 53.1% Identity: 15% PDB header:viral protein, recombination Chain: V: PDB Molecule:integrase; PDBTitle: two domain fragment of hiv-2 integrase in complex with ledgf ibd Phyre2 PDB 4mq3 chain A Region: 48 - 89 Aligned: 42 Modelled: 42 Confidence: 30.8% Identity: 19% PDB header:viral protein Chain: A: PDB Molecule:integrase; PDBTitle: the 1.1 angstrom structure of catalytic core domain of fiv integrase Phyre2 PDB 2h5g chain A Region: 7 - 45 Aligned: 39 Modelled: 37 Confidence: 30.3% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:delta 1-pyrroline-5-carboxylate synthetase; PDBTitle: crystal structure of human pyrroline-5-carboxylate synthetase Phyre2 PDB 1ex4 chain A Region: 48 - 69 Aligned: 22 Modelled: 22 Confidence: 29.9% Identity: 23% PDB header:viral protein Chain: A: PDB Molecule:integrase; PDBTitle: hiv-1 integrase catalytic core and c-terminal domain Phyre2 PDB 2dmn chain A Region: 7 - 48 Aligned: 42 Modelled: 42 Confidence: 27.8% Identity: 17% PDB header:transcription Chain: A: PDB Molecule:homeobox protein tgif2lx; PDBTitle: the solution structure of the homeobox domain of human2 homeobox protein tgif2lx Phyre2 PDB 1o20 chain A Region: 7 - 69 Aligned: 63 Modelled: 63 Confidence: 27.8% Identity: 14% Fold: ALDH-like Superfamily: ALDH-like Family: ALDH-like Phyre2 PDB 3nf9 chain A Region: 48 - 87 Aligned: 40 Modelled: 40 Confidence: 27.4% Identity: 18% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:integrase; PDBTitle: structural basis for a new mechanism of inhibition of hiv integrase2 identified by fragment screening and structure based design Phyre2 PDB 3k9d chain D Region: 7 - 70 Aligned: 64 Modelled: 64 Confidence: 26.7% Identity: 9% PDB header:oxidoreductase Chain: D: PDB Molecule:aldehyde dehydrogenase; PDBTitle: crystal structure of probable aldehyde dehydrogenase from listeria2 monocytogenes egd-e Phyre2 PDB 1e3o chain C domain 1 Region: 6 - 49 Aligned: 44 Modelled: 44 Confidence: 25.7% Identity: 9% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: Homeodomain Phyre2 PDB 1vlu chain B Region: 7 - 58 Aligned: 52 Modelled: 52 Confidence: 25.6% Identity: 12% PDB header:oxidoreductase Chain: B: PDB Molecule:gamma-glutamyl phosphate reductase; PDBTitle: crystal structure of gamma-glutamyl phosphate reductase (yor323c) from2 saccharomyces cerevisiae at 2.40 a resolution Phyre2 PDB 5kw2 chain A Region: 2 - 70 Aligned: 69 Modelled: 69 Confidence: 25.6% Identity: 12% PDB header:fatty acid binding protein/hydrolase Chain: A: PDB Molecule:free fatty acid receptor 1,lysozyme,free fatty acid PDBTitle: the extra-helical binding site of gpr40 and the structural basis for2 allosteric agonism and incretin stimulation Phyre2 PDB 1akh chain A Region: 6 - 49 Aligned: 44 Modelled: 44 Confidence: 25.2% Identity: 7% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: Homeodomain Phyre2 PDB 2dmp chain A Region: 2 - 49 Aligned: 48 Modelled: 48 Confidence: 24.9% Identity: 15% PDB header:dna binding protein Chain: A: PDB Molecule:zinc fingers and homeoboxes protein 2; PDBTitle: solution structure of the third homeobox domain of zinc2 fingers and homeoboxes protein 2 Phyre2 PDB 5cz1 chain B Region: 48 - 82 Aligned: 35 Modelled: 35 Confidence: 24.5% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:integrase; PDBTitle: crystal structure of the catalytic core domain of mmtv integrase Phyre2 PDB 4jbe chain A Region: 7 - 45 Aligned: 39 Modelled: 39 Confidence: 24.5% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:gamma-glutamyl phosphate reductase; PDBTitle: 1.95 angstrom crystal structure of gamma-glutamyl phosphate reductase2 from saccharomonospora viridis. Phyre2 PDB 5j78 chain B Region: 7 - 71 Aligned: 65 Modelled: 65 Confidence: 24.2% Identity: 14% PDB header:oxidoreductase Chain: B: PDB Molecule:acetaldehyde dehydrogenase (acetylating); PDBTitle: crystal structure of an acetylating aldehyde dehydrogenase from2 geobacillus thermoglucosidasius Phyre2 PDB 1dl5 chain A domain 2 Region: 24 - 78 Aligned: 55 Modelled: 55 Confidence: 24.1% Identity: 31% Fold: Protein-L-isoaspartyl O-methyltransferase, C-terminal domain Superfamily: Protein-L-isoaspartyl O-methyltransferase, C-terminal domain Family: Protein-L-isoaspartyl O-methyltransferase, C-terminal domain Phyre2 PDB 1hlv chain A domain 2 Region: 7 - 58 Aligned: 52 Modelled: 52 Confidence: 22.8% Identity: 13% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: Centromere-binding Phyre2 1 c1k6yB_ 2 d1hyva_ 3 c3f9kV_ 4 c4mq3A_ 5 c2h5gA_ 6 c1ex4A_ 7 c2dmnA_ 8 d1o20a_ 9 c3nf9A_ 10 c3k9dD_ 11 d1e3oc1 12 c1vluB_ 13 c5kw2A_ 14 d1akha_ 15 c2dmpA_ 16 c5cz1B_ 17 c4jbeA_ 18 c5j78B_ 19 d1dl5a2 20 d1hlva2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99