1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.
Sequence		M	L	G	L	A	M	E	A	V	A	S	T	G	A	A	A	P	L	G	S	H	A	A	Q	I	Y	A	K	F	A	A	D	H	A	D	L	D	F	S	A	V	I	E	T	L	R	G	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?					?	?	?	?	?	?		?																													?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 31%) Alpha helix ( 83%) Beta strand ( 0%)

Rank Aligned region

PDB 5y8m chain A Region: 2 - 47 Aligned: 46 Modelled: 46 Confidence: 95.3% Identity: 87% PDB header:oxidoreductase Chain: A: PDB Molecule:probable 3-hydroxyisobutyrate dehydrogenase; PDBTitle: mycobacterium tuberculosis 3-hydroxyisobutyrate dehydrogenase2 (mthibadh) + nad + (r)-3-hydroxyisobutyrate (r-hiba) Phyre2 PDB 1vpd chain A domain 1 Region: 2 - 46 Aligned: 45 Modelled: 45 Confidence: 92.3% Identity: 27% Fold: 6-phosphogluconate dehydrogenase C-terminal domain-like Superfamily: 6-phosphogluconate dehydrogenase C-terminal domain-like Family: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain Phyre2 PDB 3doj chain A Region: 2 - 48 Aligned: 47 Modelled: 47 Confidence: 86.2% Identity: 32% PDB header:oxidoreductase Chain: A: PDB Molecule:dehydrogenase-like protein; PDBTitle: structure of glyoxylate reductase 1 from arabidopsis (atglyr1) Phyre2 PDB 2cvz chain A domain 1 Region: 2 - 46 Aligned: 45 Modelled: 45 Confidence: 85.3% Identity: 24% Fold: 6-phosphogluconate dehydrogenase C-terminal domain-like Superfamily: 6-phosphogluconate dehydrogenase C-terminal domain-like Family: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain Phyre2 PDB 3cum chain A domain 1 Region: 2 - 45 Aligned: 44 Modelled: 44 Confidence: 83.6% Identity: 36% Fold: 6-phosphogluconate dehydrogenase C-terminal domain-like Superfamily: 6-phosphogluconate dehydrogenase C-terminal domain-like Family: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain Phyre2 PDB 4dll chain B Region: 2 - 46 Aligned: 45 Modelled: 44 Confidence: 77.9% Identity: 27% PDB header:oxidoreductase Chain: B: PDB Molecule:2-hydroxy-3-oxopropionate reductase; PDBTitle: crystal structure of a 2-hydroxy-3-oxopropionate reductase from2 polaromonas sp. js666 Phyre2 PDB 1yb4 chain A Region: 2 - 46 Aligned: 45 Modelled: 45 Confidence: 75.8% Identity: 24% PDB header:oxidoreductase Chain: A: PDB Molecule:tartronic semialdehyde reductase; PDBTitle: crystal structure of the tartronic semialdehyde reductase from2 salmonella typhimurium lt2 Phyre2 PDB 2gf2 chain B Region: 2 - 46 Aligned: 45 Modelled: 45 Confidence: 74.5% Identity: 44% PDB header:oxidoreductase Chain: B: PDB Molecule:3-hydroxyisobutyrate dehydrogenase; PDBTitle: crystal structure of human hydroxyisobutyrate dehydrogenase Phyre2 PDB 3cum chain A Region: 2 - 48 Aligned: 47 Modelled: 47 Confidence: 73.8% Identity: 34% PDB header:oxidoreductase Chain: A: PDB Molecule:probable 3-hydroxyisobutyrate dehydrogenase; PDBTitle: crystal structure of a possible 3-hydroxyisobutyrate dehydrogenase2 from pseudomonas aeruginosa pao1 Phyre2 PDB 2cvz chain D Region: 2 - 46 Aligned: 45 Modelled: 45 Confidence: 67.5% Identity: 24% PDB header:oxidoreductase Chain: D: PDB Molecule:3-hydroxyisobutyrate dehydrogenase; PDBTitle: structure of hydroxyisobutyrate dehydrogenase from thermus2 thermophilus hb8 Phyre2 PDB 5g6s chain D Region: 2 - 46 Aligned: 45 Modelled: 45 Confidence: 64.6% Identity: 16% PDB header:oxidoreductase Chain: D: PDB Molecule:imine reductase; PDBTitle: imine reductase from aspergillus oryzae in complex with nadp(h) and2 (r)-rasagiline Phyre2 PDB 5je8 chain A Region: 2 - 46 Aligned: 45 Modelled: 45 Confidence: 63.6% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:3-hydroxyisobutyrate dehydrogenase; PDBTitle: the crystal structure of bacillus cereus 3-hydroxyisobutyrate2 dehydrogenase in complex with nad Phyre2 PDB 4gbj chain B Region: 2 - 46 Aligned: 45 Modelled: 45 Confidence: 61.3% Identity: 16% PDB header:oxidoreductase Chain: B: PDB Molecule:6-phosphogluconate dehydrogenase nad-binding; PDBTitle: crystal structure of nad-binding 6-phosphogluconate dehydrogenase from2 dyadobacter fermentans Phyre2 PDB 3zhb chain C Region: 2 - 47 Aligned: 46 Modelled: 46 Confidence: 56.1% Identity: 22% PDB header:oxidoreductase Chain: C: PDB Molecule:r-imine reductase; PDBTitle: r-imine reductase from streptomyces kanamyceticus in2 complex with nadp. Phyre2 PDB 4d3f chain B Region: 2 - 46 Aligned: 45 Modelled: 45 Confidence: 54.0% Identity: 16% PDB header:oxidoreductase Chain: B: PDB Molecule:imine reductase; PDBTitle: bcsired from bacillus cereus in complex with nadph Phyre2 PDB 4d3s chain A Region: 2 - 47 Aligned: 46 Modelled: 46 Confidence: 52.5% Identity: 11% PDB header:oxidoreductase Chain: A: PDB Molecule:imine reductase; PDBTitle: imine reductase from nocardiopsis halophila Phyre2 PDB 4oqy chain A Region: 2 - 46 Aligned: 45 Modelled: 45 Confidence: 52.5% Identity: 22% PDB header:oxidoreductase Chain: A: PDB Molecule:(s)-imine reductase; PDBTitle: streptomyces sp. gf3546 imine reductase Phyre2 PDB 3pdu chain F Region: 2 - 47 Aligned: 46 Modelled: 46 Confidence: 45.5% Identity: 35% PDB header:oxidoreductase Chain: F: PDB Molecule:3-hydroxyisobutyrate dehydrogenase family protein; PDBTitle: crystal structure of gamma-hydroxybutyrate dehydrogenase from2 geobacter sulfurreducens in complex with nadp+ Phyre2 PDB 3l6d chain B Region: 2 - 46 Aligned: 45 Modelled: 45 Confidence: 41.8% Identity: 16% PDB header:oxidoreductase Chain: B: PDB Molecule:putative oxidoreductase; PDBTitle: crystal structure of putative oxidoreductase from pseudomonas putida2 kt2440 Phyre2 PDB 6grl chain A Region: 2 - 45 Aligned: 44 Modelled: 44 Confidence: 38.9% Identity: 23% PDB header:oxidoreductase Chain: A: PDB Molecule:beta-hydroxyacid dehydrogenase, 3-hydroxyisobutyrate PDBTitle: structure of imine reductase (apo form) at 1.6 a resolution from2 saccharomonospora xinjiangensis Phyre2 1 c5y8mA_ 2 d1vpda1 3 c3dojA_ 4 d2cvza1 5 d3cuma1 6 c4dllB_ 7 c1yb4A_ 8 c2gf2B_ 9 c3cumA_ 10 c2cvzD_ 11 c5g6sD_ 12 c5je8A_ 13 c4gbjB_ 14 c3zhbC_ 15 c4d3fB_ 16 c4d3sA_ 17 c4oqyA_ 18 c3pduF_ 19 c3l6dB_ 20 c6grlA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43