1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	T	Q	I	S	H	F	I	D	G	Q	R	T	A	G	Q	S	T	R	S	A	D	V	F	D	P	N	T	G	Q	I	Q	A	K	V	P	M	A	G	K	S	D	I	D	A	A	V	A	S	A	V	E	A	Q	K	G	W	A	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		W	N	P	Q	R	R	A	R	V	L	M	R	F	I	E	L	V	N	D	T	I	D	E	L	A	E	L	L	S	R	E	H	G	K	T	L	A	D	A	R	G	D	V	Q	R	G	I	E	V	I	E	F	C	L	G	I	P	H	L	L
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		K	G	E	Y	T	E	G	A	G	P	G	I	D	V	Y	S	L	R	Q	P	L	G	V	V	A	G	I	T	P	F	N	F	P	A	M	I	P	L	W	K	A	G	P	A	L	A	C	G	N	A	F	V	L	K	P	S	E	R	D	P
Secondary structure
SS confidence
Disorder								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	V	P	V	R	L	A	E	L	F	I	E	A	G	L	P	A	G	V	F	Q	V	V	H	G	D	K	E	A	V	D	A	I	L	H	H	P	D	I	K	A	V	G	F	V	G	S	S	D	I	A	Q	Y	I	Y	A	G	A	A	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	G	K	R	A	Q	C	F	G	G	A	K	N	H	M	I	V	M	P	D	A	D	L	D	Q	A	V	D	A	L	I	G	A	G	Y	G	S	A	G	E	R	C	M	A	I	S	V	A	V	P	V	G	D	Q	T	A	E	R	L	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	R	L	I	E	R	I	N	N	L	R	V	G	H	S	L	D	P	K	A	D	Y	G	P	L	V	T	G	A	A	L	A	R	V	R	D	Y	I	G	Q	G	V	A	A	G	A	E	L	V	V	D	G	R	D	R	A	S	D	D	L
Secondary structure
SS confidence
Disorder																																																										?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		T	F	G	L	P	E	G	D	A	N	L	E	G	G	F	F	I	G	P	T	L	F	D	H	V	A	A	H	M	S	I	Y	T	D	E	I	F	G	P	V	L	C	M	V	R	A	R	D	Y	E	E	A	L	R	L	P	S	E	H	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		Y	G	N	G	V	A	I	F	T	R	D	G	D	A	A	R	D	F	V	S	R	V	Q	V	G	M	V	G	V	N	V	P	I	P	V	P	V	A	Y	H	T	F	G	G	W	K	R	S	G	F	G	D	L	N	Q	H	G	P	A	A
Secondary structure
SS confidence
Disorder																																																						?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510
Sequence		I	Q	F	Y	T	K	V	K	T	V	T	S	R	W	P	S	G	I	K	D	G	A	E	F	V	I	P	T	M	S
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 38%) Beta strand ( 21%) TM helix ( 5%) (View membrane topology prediction)

Rank Aligned region

PDB 6fk3 chain B Region: 2 - 501 Aligned: 492 Modelled: 500 Confidence: 100.0% Identity: 30% PDB header:oxidoreductase Chain: B: PDB Molecule:aldehyde dehydrogenase; PDBTitle: structure and function of aldehyde dehydrogenase from thermus2 thermophilus: an enzyme with an evolutionarily-distinct c-terminal3 arm (recombinant full-length protein in complex with propanal) Phyre2 PDB 4f9i chain A Region: 1 - 494 Aligned: 474 Modelled: 478 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: A: PDB Molecule:proline dehydrogenase/delta-1-pyrroline-5-carboxylate PDBTitle: crystal structure of proline utilization a (puta) from geobacter2 sulfurreducens pca Phyre2 PDB 4zz7 chain E Region: 3 - 496 Aligned: 482 Modelled: 494 Confidence: 100.0% Identity: 55% PDB header:oxidoreductase Chain: E: PDB Molecule:methylmalonate-semialdehyde dehydrogenase; PDBTitle: crystal structure of methylmalonate-semialdehyde dehydrogenase (dddc)2 from oceanimonas doudoroffii Phyre2 PDB 5ur2 chain C Region: 1 - 493 Aligned: 472 Modelled: 476 Confidence: 100.0% Identity: 30% PDB header:oxidoreductase Chain: C: PDB Molecule:bifunctional protein puta; PDBTitle: crystal structure of proline utilization a (puta) from bdellovibrio2 bacteriovorus inactivated by n-propargylglycine Phyre2 PDB 4e4g chain F Region: 4 - 498 Aligned: 484 Modelled: 484 Confidence: 100.0% Identity: 66% PDB header:oxidoreductase Chain: F: PDB Molecule:methylmalonate-semialdehyde dehydrogenase; PDBTitle: crystal structure of putative methylmalonate-semialdehyde2 dehydrogenase from sinorhizobium meliloti 1021 Phyre2 PDB 3ed6 chain B Region: 2 - 500 Aligned: 484 Modelled: 499 Confidence: 100.0% Identity: 28% PDB header:oxidoreductase Chain: B: PDB Molecule:betaine aldehyde dehydrogenase; PDBTitle: 1.7 angstrom resolution crystal structure of betaine aldehyde2 dehydrogenase (betb) from staphylococcus aureus Phyre2 PDB 1a4s chain A Region: 1 - 494 Aligned: 480 Modelled: 494 Confidence: 100.0% Identity: 31% Fold: ALDH-like Superfamily: ALDH-like Family: ALDH-like Phyre2 PDB 2jg7 chain G Region: 1 - 504 Aligned: 484 Modelled: 489 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: G: PDB Molecule:antiquitin; PDBTitle: crystal structure of seabream antiquitin and elucidation of2 its substrate specificity Phyre2 PDB 1t90 chain B Region: 3 - 496 Aligned: 479 Modelled: 480 Confidence: 100.0% Identity: 43% PDB header:oxidoreductase Chain: B: PDB Molecule:probable methylmalonate-semialdehyde dehydrogenase; PDBTitle: crystal structure of methylmalonate semialdehyde dehydrogenase from2 bacillus subtilis Phyre2 PDB 3u4j chain B Region: 1 - 499 Aligned: 480 Modelled: 484 Confidence: 100.0% Identity: 31% PDB header:oxidoreductase Chain: B: PDB Molecule:nad-dependent aldehyde dehydrogenase; PDBTitle: crystal structure of nad-dependent aldehyde dehydrogenase from2 sinorhizobium meliloti Phyre2 PDB 2d4e chain B Region: 2 - 509 Aligned: 489 Modelled: 506 Confidence: 100.0% Identity: 34% PDB header:oxidoreductase Chain: B: PDB Molecule:5-carboxymethyl-2-hydroxymuconate semialdehyde PDBTitle: crystal structure of the hpcc from thermus thermophilus hb8 Phyre2 PDB 4o5h chain D Region: 1 - 495 Aligned: 476 Modelled: 480 Confidence: 100.0% Identity: 33% PDB header:oxidoreductase Chain: D: PDB Molecule:phenylacetaldehyde dehydrogenase; PDBTitle: x-ray crystal structure of a putative phenylacetaldehyde dehydrogenase2 from burkholderia cenocepacia Phyre2 PDB 3qan chain B Region: 1 - 495 Aligned: 475 Modelled: 479 Confidence: 100.0% Identity: 29% PDB header:oxidoreductase Chain: B: PDB Molecule:1-pyrroline-5-carboxylate dehydrogenase 1; PDBTitle: crystal structure of 1-pyrroline-5-carboxylate dehydrogenase from2 bacillus halodurans Phyre2 PDB 6mvt chain A Region: 3 - 490 Aligned: 449 Modelled: 470 Confidence: 100.0% Identity: 34% PDB header:oxidoreductase Chain: A: PDB Molecule:aldehyde dehydrogenase; PDBTitle: structure of a bacterial aldh16 complexed with nadh Phyre2 PDB 5izd chain E Region: 4 - 509 Aligned: 489 Modelled: 506 Confidence: 100.0% Identity: 27% PDB header:oxidoreductase Chain: E: PDB Molecule:d-glyceraldehyde dehydrogenase (nadp(+)); PDBTitle: wild-type glyceraldehyde dehydrogenase from thermoplasma acidophilum2 in complex with nadp Phyre2 PDB 1bxs chain A Region: 3 - 496 Aligned: 474 Modelled: 479 Confidence: 100.0% Identity: 32% Fold: ALDH-like Superfamily: ALDH-like Family: ALDH-like Phyre2 PDB 3iwk chain B Region: 4 - 508 Aligned: 485 Modelled: 505 Confidence: 100.0% Identity: 32% PDB header:oxidoreductase Chain: B: PDB Molecule:aminoaldehyde dehydrogenase; PDBTitle: crystal structure of aminoaldehyde dehydrogenase 1 from pisum sativum2 (psamadh1) Phyre2 PDB 2o2q chain A Region: 1 - 494 Aligned: 475 Modelled: 479 Confidence: 100.0% Identity: 30% PDB header:oxidoreductase Chain: A: PDB Molecule:formyltetrahydrofolate dehydrogenase; PDBTitle: crystal structure of the c-terminal domain of rat2 10'formyltetrahydrofolate dehydrogenase in complex with nadp Phyre2 PDB 1o9j chain A Region: 3 - 497 Aligned: 475 Modelled: 480 Confidence: 100.0% Identity: 33% Fold: ALDH-like Superfamily: ALDH-like Family: ALDH-like Phyre2 PDB 3rh9 chain A Region: 1 - 492 Aligned: 474 Modelled: 478 Confidence: 100.0% Identity: 26% PDB header:oxidoreductase Chain: A: PDB Molecule:succinate-semialdehyde dehydrogenase (nad(p)(+)); PDBTitle: the crystal structure of oxidoreductase from marinobacter aquaeolei Phyre2 1 c6fk3B_ 2 c4f9iA_ 3 c4zz7E_ 4 c5ur2C_ 5 c4e4gF_ 6 c3ed6B_ 7 d1a4sa_ 8 c2jg7G_ 9 c1t90B_ 10 c3u4jB_ 11 c2d4eB_ 12 c4o5hD_ 13 c3qanB_ 14 c6mvtA_ 15 c5izdE_ 16 d1bxsa_ 17 c3iwkB_ 18 c2o2qA_ 19 d1o9ja_ 20 c3rh9A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128