1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	F	V	I	V	A	R	D	A	L	A	A	A	A	A	D	L	A	Q	I	G	S	A	V	N	A	G	N	L	A	A	A	N	P	T	T	A	V	A	A	A	A	A	D	E	V	S	A	A	L	A	A	L	F	G	A	H	A	R
Secondary structure
SS confidence
Disorder		?	?	?	?		?	?																					?	?	?		?		?			?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	Y	Q	A	A	A	A	Q	A	A	A	Y	H	E	Q	F	V	H	R	L	S	A	A	A	T	S	Y	A	V	T	E	V	T	I	A	T	S	L	R	G	A	L	G	S	A	P	A	S	V	S	D	G	F	Q	A	F	V	Y	G	P
Secondary structure
SS confidence
Disorder																									?	?								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	H	A	T	G	Q	Q	W	I	N	S	P	V	G	E	A	L	A	P	I	V	N	A	P	T	N	V	L	L	G	R	D	L	I	G	N	G	V	T	G	T	A	A	A	P	N	G	G	P	G	G	L	L	F	G	D	G	G	A	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?		?	?			?	?			?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Y	T	G	G	N	G	G	S	A	G	L	I	G	N	G	G	T	G	G	A	G	F	A	G	G	V	G	G	M	G	G	T	G	G	W	L	M	G	N	G	G	M	G	G	A	G	G	V	G	G	N	G	G	A	G	G	Q	A	L	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		F	G	N	G	G	L	G	G	A	G	G	A	G	G	V	D	G	A	I	G	R	G	G	W	F	I	G	T	G	G	M	A	T	I	G	G	G	G	N	G	Q	S	I	V	I	D	F	V	R	H	G	Q	T	P	G	N	A	A	M	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?		?														?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		I	D	T	A	V	P	G	P	G	L	T	A	L	G	Q	Q	Q	A	Q	A	I	A	N	A	L	A	A	K	G	P	Y	A	G	I	F	D	S	Q	L	I	R	T	Q	Q	T	A	A	P	L	A	N	L	L	G	M	A	P	Q	V	L
Secondary structure
SS confidence
Disorder				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		P	G	L	N	E	I	H	A	G	I	F	E	D	L	P	Q	I	S	P	A	G	L	L	Y	L	V	G	P	I	A	W	T	L	G	F	P	I	V	P	M	L	A	P	G	S	T	D	V	N	G	I	V	F	N	R	A	F	T	G	A
Secondary structure
SS confidence
Disorder																																					?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		V	Q	T	I	Y	D	A	S	L	A	N	P	V	V	A	A	D	G	N	I	T	S	V	A	Y	S	S	A	F	T	I	G	V	G	T	M	M	N	V	D	N	P	H	P	L	L	L	L	T	H	P	V	P	N	T	G	A	V	V	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		Q	G	N	P	E	G	G	W	T	L	V	S	W	D	G	I	P	V	G	P	A	S	L	P	T	A	L	F	V	D	V	R	E	L	I	T	A	P	Q	Y	A	A	Y	D	I	W	E	S	L	F	T	G	D	P	A	A	V	I	N	A
Secondary structure
SS confidence
Disorder																					?	?	?	?				?	?																									?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.
Sequence		V	R	D	G	A	D	E	V	G	A	A	V	V	Q	F	P	H	A	V	A	D	D	V	I	D	A	T	G	H	P	Y	L	S	G	L	P	I	G	L	P	S	L	I	P
Secondary structure
SS confidence
Disorder																																							?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 34%) Alpha helix ( 44%) Beta strand ( 8%) TM helix ( 3%) (View membrane topology prediction)

Rank Aligned region

PDB 4pz9 chain B Region: 285 - 494 Aligned: 197 Modelled: 210 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:glucosyl-3-phosphoglycerate phosphatase; PDBTitle: the native structure of mycobacterial glucosyl-3-phosphoglycerate2 phosphatase rv2419c Phyre2 PDB 3f3k chain A Region: 285 - 493 Aligned: 202 Modelled: 209 Confidence: 100.0% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ykr043c; PDBTitle: the structure of uncharacterized protein ykr043c from saccharomyces2 cerevisiae. Phyre2 PDB 2ikq chain A Region: 284 - 492 Aligned: 200 Modelled: 204 Confidence: 99.9% Identity: 20% PDB header:signaling protein, immune system Chain: A: PDB Molecule:suppressor of t-cell receptor signaling 1; PDBTitle: crystal structure of mouse sts-1 pgm domain in complex with phosphate Phyre2 PDB 3r7a chain A Region: 277 - 494 Aligned: 201 Modelled: 218 Confidence: 99.9% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate mutase, putative; PDBTitle: crystal structure of phosphoglycerate mutase from bacillus anthracis2 str. sterne Phyre2 PDB 2yn0 chain A Region: 284 - 494 Aligned: 204 Modelled: 211 Confidence: 99.9% Identity: 14% PDB header:transcription Chain: A: PDB Molecule:transcription factor tau 55 kda subunit; PDBTitle: tau55 histidine phosphatase domain Phyre2 PDB 4ij5 chain B Region: 282 - 494 Aligned: 195 Modelled: 213 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:phosphoserine phosphatase 1; PDBTitle: crystal structure of a novel-type phosphoserine phosphatase from2 hydrogenobacter thermophilus tk-6 Phyre2 PDB 3d4i chain D Region: 285 - 498 Aligned: 204 Modelled: 214 Confidence: 99.9% Identity: 23% PDB header:hydrolase Chain: D: PDB Molecule:sts-2 protein; PDBTitle: crystal structure of the 2h-phosphatase domain of sts-2 Phyre2 PDB 2qni chain A Region: 283 - 492 Aligned: 184 Modelled: 207 Confidence: 99.9% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein atu0299; PDBTitle: crystal structure of uncharacterized protein atu0299 Phyre2 PDB 1h2e chain A Region: 282 - 494 Aligned: 196 Modelled: 213 Confidence: 99.9% Identity: 18% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 3ll4 chain B Region: 285 - 506 Aligned: 215 Modelled: 222 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:uncharacterized protein ykr043c; PDBTitle: structure of the h13a mutant of ykr043c in complex with fructose-1,6-2 bisphosphate Phyre2 PDB 1e58 chain A Region: 282 - 486 Aligned: 194 Modelled: 205 Confidence: 99.9% Identity: 17% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 5zkk chain A Region: 282 - 494 Aligned: 191 Modelled: 213 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:phosphoglycerate mutase family protein, putative; PDBTitle: crystal structure of phosphoserine phosphatase from entamoeba2 histolytica Phyre2 PDB 4emb chain D Region: 285 - 488 Aligned: 195 Modelled: 204 Confidence: 99.9% Identity: 18% PDB header:isomerase Chain: D: PDB Molecule:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; PDBTitle: crystal structure of a phosphoglycerate mutase gpma from borrelia2 burgdorferi b31 Phyre2 PDB 3e9e chain B Region: 282 - 494 Aligned: 203 Modelled: 203 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:zgc:56074; PDBTitle: structure of full-length h11a mutant form of tigar from danio rerio Phyre2 PDB 1rii chain A Region: 280 - 500 Aligned: 208 Modelled: 221 Confidence: 99.9% Identity: 19% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 PDB 1yjx chain D Region: 285 - 481 Aligned: 186 Modelled: 197 Confidence: 99.9% Identity: 16% PDB header:isomerase, hydrolase Chain: D: PDB Molecule:phosphoglycerate mutase 1; PDBTitle: crystal structure of human b type phosphoglycerate mutase Phyre2 PDB 3dcy chain A Region: 283 - 494 Aligned: 202 Modelled: 209 Confidence: 99.9% Identity: 19% PDB header:apoptosis regulator Chain: A: PDB Molecule:regulator protein; PDBTitle: crystal structure a tp53-induced glycolysis and apoptosis regulator2 protein from homo sapiens. Phyre2 PDB 5vve chain A Region: 282 - 481 Aligned: 189 Modelled: 200 Confidence: 99.9% Identity: 17% PDB header:isomerase Chain: A: PDB Molecule:phosphoglycerate mutase; PDBTitle: crystal structure of phosphoglycerate mutase from naegleria fowleri Phyre2 PDB 2yn2 chain A Region: 284 - 494 Aligned: 207 Modelled: 211 Confidence: 99.9% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized protein ynl108c; PDBTitle: huf protein - paralogue of the tau55 histidine phosphatase domain Phyre2 PDB 1xq9 chain A Region: 285 - 494 Aligned: 198 Modelled: 209 Confidence: 99.9% Identity: 19% Fold: Phosphoglycerate mutase-like Superfamily: Phosphoglycerate mutase-like Family: Cofactor-dependent phosphoglycerate mutase Phyre2 1 c4pz9B_ 2 c3f3kA_ 3 c2ikqA_ 4 c3r7aA_ 5 c2yn0A_ 6 c4ij5B_ 7 c3d4iD_ 8 c2qniA_ 9 d1h2ea_ 10 c3ll4B_ 11 d1e58a_ 12 c5zkkA_ 13 c4embD_ 14 c3e9eB_ 15 d1riia_ 16 c1yjxD_ 17 c3dcyA_ 18 c5vveA_ 19 c2yn2A_ 20 d1xq9a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99