1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	F	L	T	I	E	P	M	T	Q	G	H	T	L	V	V	P	R	A	E	I	D	H	W	Q	N	V	D	P	A	L	F	G	R	V	M	S	V	S	Q	L	I	G	K	A	V	C	R	A	F	S	T	Q	R	A	G	M	I	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110
Sequence		A	G	L	E	V	P	H	L	H	I	H	V	F	P	T	R	S	L	S	D	F	G	F	A	N	V	D	R	N	P	S	P	G	S	L	D	E	A	Q	A	K	I	R	A	A	L	A	Q	L	A
Secondary structure
SS confidence
Disorder																												?	?																				?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 39%) Beta strand ( 22%)

Rank Aligned region

PDB 3p0t chain B Region: 1 - 110 Aligned: 110 Modelled: 110 Confidence: 100.0% Identity: 86% PDB header:unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of an hit-like protein from mycobacterium2 paratuberculosis Phyre2 PDB 3i24 chain B Region: 2 - 110 Aligned: 109 Modelled: 109 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:hit family hydrolase; PDBTitle: crystal structure of a hit family hydrolase protein from vibrio2 fischeri. northeast structural genomics consortium target id vfr176 Phyre2 PDB 3ohe chain A Region: 2 - 110 Aligned: 109 Modelled: 108 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:histidine triad (hit) protein; PDBTitle: crystal structure of a histidine triad protein (maqu_1709) from2 marinobacter aquaeolei vt8 at 1.20 a resolution Phyre2 PDB 3l7x chain A Region: 1 - 107 Aligned: 107 Modelled: 107 Confidence: 100.0% Identity: 25% PDB header:cell cycle Chain: A: PDB Molecule:putative hit-like protein involved in cell-cycle PDBTitle: the crystal structure of smu.412c from streptococcus mutans ua159 Phyre2 PDB 3nrd chain B Region: 1 - 106 Aligned: 106 Modelled: 98 Confidence: 100.0% Identity: 19% PDB header:nucleotide binding protein Chain: B: PDB Molecule:histidine triad (hit) protein; PDBTitle: crystal structure of a histidine triad (hit) protein (smc02904) from2 sinorhizobium meliloti 1021 at 2.06 a resolution Phyre2 PDB 3i4s chain B Region: 2 - 106 Aligned: 105 Modelled: 105 Confidence: 100.0% Identity: 13% PDB header:hydrolase Chain: B: PDB Molecule:histidine triad protein; PDBTitle: crystal structure of histidine triad protein blr8122 from2 bradyrhizobium japonicum Phyre2 PDB 2oik chain A domain 1 Region: 1 - 107 Aligned: 107 Modelled: 107 Confidence: 100.0% Identity: 14% Fold: HIT-like Superfamily: HIT-like Family: HIT (HINT, histidine triad) family of protein kinase-interacting proteins Phyre2 PDB 5cs2 chain A Region: 1 - 108 Aligned: 99 Modelled: 108 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:histidine triad protein; PDBTitle: crystal structure of plasmodium falciparum diadenosine triphosphate2 hydrolase in complex with cyclomarin a Phyre2 PDB 3ksv chain A Region: 1 - 109 Aligned: 109 Modelled: 109 Confidence: 100.0% Identity: 22% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: hypothetical protein from leishmania major Phyre2 PDB 6iq1 chain A Region: 1 - 109 Aligned: 109 Modelled: 109 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:adenosine 5'-monophosphoramidase; PDBTitle: crystal structure of histidine triad nucleotide-binding protein from2 candida albicans Phyre2 PDB 1fit chain A Region: 1 - 107 Aligned: 100 Modelled: 107 Confidence: 99.9% Identity: 24% Fold: HIT-like Superfamily: HIT-like Family: HIT (HINT, histidine triad) family of protein kinase-interacting proteins Phyre2 PDB 3ano chain A Region: 1 - 109 Aligned: 105 Modelled: 109 Confidence: 99.9% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:ap-4-a phosphorylase; PDBTitle: crystal structure of a novel diadenosine 5',5'''-p1,p4-tetraphosphate2 phosphorylase from mycobacterium tuberculosis h37rv Phyre2 PDB 3imi chain B Region: 1 - 107 Aligned: 107 Modelled: 107 Confidence: 99.9% Identity: 24% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hit family protein; PDBTitle: 2.01 angstrom resolution crystal structure of a hit family protein2 from bacillus anthracis str. 'ames ancestor' Phyre2 PDB 1ems chain B Region: 1 - 106 Aligned: 96 Modelled: 106 Confidence: 99.9% Identity: 26% PDB header:antitumor protein Chain: B: PDB Molecule:nit-fragile histidine triad fusion protein; PDBTitle: crystal structure of the c. elegans nitfhit protein Phyre2 PDB 2eo4 chain A Region: 1 - 109 Aligned: 109 Modelled: 109 Confidence: 99.9% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:150aa long hypothetical histidine triad nucleotide-binding PDBTitle: crystal structure of hypothetical histidine triad nucleotide-binding2 protein st2152 from sulfolobus tokodaii strain7 Phyre2 PDB 1ems chain A domain 1 Region: 1 - 106 Aligned: 98 Modelled: 106 Confidence: 99.9% Identity: 26% Fold: HIT-like Superfamily: HIT-like Family: HIT (HINT, histidine triad) family of protein kinase-interacting proteins Phyre2 PDB 3o0m chain B Region: 1 - 109 Aligned: 103 Modelled: 109 Confidence: 99.9% Identity: 32% PDB header:hydrolase Chain: B: PDB Molecule:hit family protein; PDBTitle: crystal structure of a zn-bound histidine triad family protein from2 mycobacterium smegmatis Phyre2 PDB 3r6f chain A Region: 1 - 107 Aligned: 106 Modelled: 107 Confidence: 99.9% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:hit family protein; PDBTitle: crystal structure of a zinc-containing hit family protein from2 encephalitozoon cuniculi Phyre2 PDB 1y23 chain A Region: 1 - 107 Aligned: 107 Modelled: 107 Confidence: 99.9% Identity: 26% Fold: HIT-like Superfamily: HIT-like Family: HIT (HINT, histidine triad) family of protein kinase-interacting proteins Phyre2 PDB 3lb5 chain B Region: 1 - 106 Aligned: 101 Modelled: 106 Confidence: 99.9% Identity: 35% PDB header:cell cycle Chain: B: PDB Molecule:hit-like protein involved in cell-cycle regulation; PDBTitle: crystal structure of hit-like protein involved in cell-cycle2 regulation from bartonella henselae with unknown ligand Phyre2 1 c3p0tB_ 2 c3i24B_ 3 c3oheA_ 4 c3l7xA_ 5 c3nrdB_ 6 c3i4sB_ 7 d2oika1 8 c5cs2A_ 9 c3ksvA_ 10 c6iq1A_ 11 d1fita_ 12 c3anoA_ 13 c3imiB_ 14 c1emsB_ 15 c2eo4A_ 16 d1emsa1 17 c3o0mB_ 18 c3r6fA_ 19 d1y23a_ 20 c3lb5B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99