1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	G	Y	P	R	D	E	L	E	D	V	V	H	R	W	L	Q	A	N	R	T	A	E	R	R	G	D	W	T	L	L	A	D	F	Y	T	D	D	A	T	Y	G	W	N	V	G	P	N	E	D	V	M	C	V	G	I	D	E	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?																			?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	D	I	A	L	G	Q	E	M	D	G	L	Q	G	W	R	Y	P	Y	Q	R	V	V	I	D	E	K	Q	G	E	V	V	G	F	W	K	Q	V	A	T	D	A	N	G	A	E	Q	E	V	Y	G	I	G	G	S	W	F	R	Y	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	G	G	K	W	N	W	Q	R	D	F	F	D	F	G	H	V	S	A	L	Y	L	E	L	I	K	A	G	K	L	S	P	G	M	Q	K	R	I	E	R	A	V	S	G	N	K	V	P	G	Y	Y	P	L	G	K	T	P	V	P	L
Secondary structure
SS confidence
Disorder																													?	?	?											?	?																?	?	?
Disorder confidence
		.
Sequence		W
Secondary structure
SS confidence
Disorder		?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 39%) Beta strand ( 17%)

Rank Aligned region

PDB 3hx8 chain A Region: 10 - 133 Aligned: 120 Modelled: 124 Confidence: 99.5% Identity: 18% PDB header:isomerase Chain: A: PDB Molecule:putative ketosteroid isomerase; PDBTitle: crystal structure of putative ketosteroid isomerase (np_103587.1) from2 mesorhizobium loti at 1.45 a resolution Phyre2 PDB 3rob chain C Region: 6 - 130 Aligned: 120 Modelled: 125 Confidence: 99.5% Identity: 23% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:uncharacterized conserved protein; PDBTitle: the crystal structure of a conserved protein from planctomyces2 limnophilus dsm 3776 Phyre2 PDB 2gxf chain A domain 1 Region: 10 - 133 Aligned: 109 Modelled: 124 Confidence: 99.5% Identity: 17% Fold: Cystatin-like Superfamily: NTF2-like Family: YybH-like Phyre2 PDB 3d9r chain A domain 1 Region: 8 - 133 Aligned: 121 Modelled: 126 Confidence: 99.4% Identity: 21% Fold: Cystatin-like Superfamily: NTF2-like Family: ECA1476-like Phyre2 PDB 3wmd chain A Region: 10 - 133 Aligned: 118 Modelled: 124 Confidence: 99.4% Identity: 15% PDB header:isomerase Chain: A: PDB Molecule:probable monensin biosynthesis isomerase; PDBTitle: crystal structure of epoxide hydrolase monbi Phyre2 PDB 5cxo chain A Region: 10 - 138 Aligned: 123 Modelled: 129 Confidence: 99.4% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:epoxide hydrolase; PDBTitle: intriguing role of epoxide hydrolase/cyclase-like enzyme salbiii in2 pyran ring formation in polyether salinomycin Phyre2 PDB 5aig chain A Region: 14 - 139 Aligned: 117 Modelled: 126 Confidence: 99.3% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:limonene-1,2-epoxide hydrolase; PDBTitle: discovery and characterization of thermophilic limonene-1,2-epoxide2 hydrolases from hot spring metagenomic libraries. tomsk-sample-3 valpromide complex Phyre2 PDB 1s5a chain A Region: 8 - 139 Aligned: 127 Modelled: 132 Confidence: 99.3% Identity: 14% Fold: Cystatin-like Superfamily: NTF2-like Family: PhzA/PhzB-like Phyre2 PDB 2a15 chain A domain 1 Region: 5 - 136 Aligned: 124 Modelled: 130 Confidence: 99.3% Identity: 11% Fold: Cystatin-like Superfamily: NTF2-like Family: Ketosteroid isomerase-like Phyre2 PDB 1oh0 chain A Region: 10 - 137 Aligned: 120 Modelled: 128 Confidence: 99.3% Identity: 16% Fold: Cystatin-like Superfamily: NTF2-like Family: Ketosteroid isomerase-like Phyre2 PDB 3bb9 chain A domain 1 Region: 9 - 126 Aligned: 110 Modelled: 118 Confidence: 99.2% Identity: 7% Fold: Cystatin-like Superfamily: NTF2-like Family: SO0125-like Phyre2 PDB 2gex chain A domain 1 Region: 10 - 139 Aligned: 122 Modelled: 130 Confidence: 99.2% Identity: 13% Fold: Cystatin-like Superfamily: NTF2-like Family: SnoaL-like polyketide cyclase Phyre2 PDB 3bb9 chain D Region: 9 - 126 Aligned: 112 Modelled: 118 Confidence: 99.2% Identity: 8% PDB header:unknown function Chain: D: PDB Molecule:putative orphan protein; PDBTitle: crystal structure of a putative ketosteroid isomerase (sfri_1973) from2 shewanella frigidimarina ncimb 400 at 1.80 a resolution Phyre2 PDB 3b4o chain B Region: 6 - 139 Aligned: 129 Modelled: 134 Confidence: 99.2% Identity: 9% PDB header:biosynthetic protein Chain: B: PDB Molecule:phenazine biosynthesis protein a/b; PDBTitle: crystal structure of phenazine biosynthesis protein phza/b2 from burkholderia cepacia r18194, apo form Phyre2 PDB 3ff0 chain A Region: 5 - 139 Aligned: 130 Modelled: 135 Confidence: 99.2% Identity: 13% PDB header:biosynthetic protein Chain: A: PDB Molecule:phenazine biosynthesis protein phzb 2; PDBTitle: crystal structure of a phenazine biosynthesis-related protein (phzb2)2 from pseudomonas aeruginosa at 1.90 a resolution Phyre2 PDB 1ohp chain A domain 1 Region: 10 - 137 Aligned: 118 Modelled: 128 Confidence: 99.1% Identity: 21% Fold: Cystatin-like Superfamily: NTF2-like Family: Ketosteroid isomerase-like Phyre2 PDB 3ke7 chain A Region: 10 - 134 Aligned: 117 Modelled: 122 Confidence: 99.1% Identity: 9% PDB header:isomerase Chain: A: PDB Molecule:putative ketosteroid isomerase; PDBTitle: crystal structure of putative ketosteroid isomerase (yp_001303366.1)2 from parabacteroides distasonis atcc 8503 at 1.45 a resolution Phyre2 PDB 4h3u chain B Region: 15 - 139 Aligned: 116 Modelled: 125 Confidence: 99.1% Identity: 13% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of hypothetical protein with ketosteroid isomerase-2 like protein fold from catenulispora acidiphila dsm 44928 Phyre2 PDB 1nww chain A Region: 14 - 148 Aligned: 125 Modelled: 135 Confidence: 99.1% Identity: 16% Fold: Cystatin-like Superfamily: NTF2-like Family: Limonene-1,2-epoxide hydrolase-like Phyre2 PDB 3soy chain A Region: 7 - 126 Aligned: 116 Modelled: 120 Confidence: 99.1% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:ntf2-like superfamily protein; PDBTitle: nuclear transport factor 2 (ntf2-like) superfamily protein from2 salmonella enterica subsp. enterica serovar typhimurium str. lt2 Phyre2 1 c3hx8A_ 2 c3robC_ 3 d2gxfa1 4 d3d9ra1 5 c3wmdA_ 6 c5cxoA_ 7 c5aigA_ 8 d1s5aa_ 9 d2a15a1 10 d1oh0a_ 11 d3bb9a1 12 d2gexa1 13 c3bb9D_ 14 c3b4oB_ 15 c3ff0A_ 16 d1ohpa1 17 c3ke7A_ 18 c4h3uB_ 19 d1nwwa_ 20 c3soyA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147