1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	I	L	A	T	N	V	V	C	T	S	Q	P	L	A	A	Q	A	G	L	R	M	L	A	D	G	G	N	A	V	D	A	A	V	A	T	A	I	T	L	T	V	V	E	P	V	S	N	G	I	G	S	D	A	F	S	I	V	W
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	G	Q	K	L	H	G	L	N	A	S	G	R	S	P	S	A	W	T	P	E	Y	F	G	G	N	A	V	P	V	L	G	W	N	S	V	T	V	P	G	A	V	S	A	W	V	E	L	H	A	R	F	G	R	L	P	F	E	T	L
Secondary structure
SS confidence
Disorder																										?				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	E	P	A	I	S	Y	G	R	N	G	F	L	V	S	P	T	V	A	A	Q	W	A	A	Q	V	P	L	F	A	S	Q	P	G	F	A	D	A	F	M	P	G	G	R	A	P	K	P	G	E	L	F	T	F	P	D	H	A	A	T
Secondary structure
SS confidence
Disorder																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	E	K	I	A	A	T	N	G	E	E	F	Y	R	G	E	L	A	A	K	L	E	A	H	S	A	A	N	G	G	V	M	R	A	D	D	L	A	A	H	R	V	D	W	V	D	T	I	T	G	T	Y	R	G	Y	T	I	H	Q	I
Secondary structure
SS confidence
Disorder										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	P	N	G	Q	G	I	V	A	L	I	A	L	G	I	L	E	H	F	D	M	S	S	W	S	V	D	S	A	E	S	V	H	V	Q	I	E	A	L	K	L	A	F	A	D	A	Q	A	C	V	A	D	I	D	Y	M	P	V	H	P
Secondary structure
SS confidence
Disorder																						?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		K	R	L	L	D	K	E	Y	L	R	Q	R	A	T	L	I	D	P	K	R	A	M	P	A	A	T	G	I	P	R	G	G	T	V	Y	L	A	A	A	D	A	A	G	M	M	V	S	M	I	Q	S	N	Y	L	G	F	G	S	G	V
Secondary structure
SS confidence
Disorder																			?		?	?	?	?	?	?	?	?	?																								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	V	P	G	T	G	I	S	L	H	N	R	G	S	D	F	T	V	V	P	R	H	P	N	R	V	G	P	R	K	R	P	Y	H	T	I	I	P	G	F	V	T	R	D	G	A	P	V	M	S	F	G	V	M	G	G	M	M	Q	P
Secondary structure
SS confidence
Disorder															?			?																																						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		Q	G	H	V	Q	V	L	V	R	I	A	D	Y	G	Q	N	P	Q	A	A	C	D	G	P	R	F	R	W	V	N	G	M	R	V	S	F	E	N	G	F	P	D	S	T	L	D	E	L	R	Q	R	G	H	D	L	V	A	V	A	D
Secondary structure
SS confidence
Disorder																																																											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.
Sequence		Y	S	Q	F	G	S	C	Q	A	I	W	R	L	D	D	G	Y	L	A	A	S	D	P	R	R	D	G	Q	A	A	A	C
Secondary structure
SS confidence
Disorder		?	?																										?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 39%) Beta strand ( 21%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 4y23 chain A Region: 1 - 511 Aligned: 508 Modelled: 511 Confidence: 100.0% Identity: 29% PDB header:transferase Chain: A: PDB Molecule:gamma glutamyl transpeptidase,gamma-glutamyltranspeptidase; PDBTitle: crystal structure of t399a precursor mutant protein of gamma-glutamyl2 transpeptidase from bacillus licheniformis Phyre2 PDB 2nlz chain A domain 1 Region: 3 - 511 Aligned: 503 Modelled: 509 Confidence: 100.0% Identity: 50% Fold: Ntn hydrolase-like Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family: Gamma-glutamyltranspeptidase-like Phyre2 PDB 2i3o chain A domain 1 Region: 2 - 510 Aligned: 482 Modelled: 484 Confidence: 100.0% Identity: 31% Fold: Ntn hydrolase-like Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family: Gamma-glutamyltranspeptidase-like Phyre2 PDB 2e0w chain A Region: 2 - 510 Aligned: 468 Modelled: 492 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:gamma-glutamyltranspeptidase; PDBTitle: t391a precursor mutant protein of gamma-glutamyltranspeptidase from2 escherichia coli Phyre2 PDB 2v36 chain A Region: 1 - 341 Aligned: 338 Modelled: 341 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:gamma-glutamyltranspeptidase large chain; PDBTitle: crystal structure of gamma-glutamyl transferase from bacillus subtilis Phyre2 PDB 2qm6 chain C Region: 5 - 335 Aligned: 331 Modelled: 331 Confidence: 100.0% Identity: 28% PDB header:transferase Chain: C: PDB Molecule:gamma-glutamyltranspeptidase; PDBTitle: crystal structure of helicobacter pylori gamma-glutamyltranspeptidase2 in complex with glutamate Phyre2 PDB 2z8j chain A Region: 2 - 330 Aligned: 329 Modelled: 329 Confidence: 100.0% Identity: 29% PDB header:transferase Chain: A: PDB Molecule:gamma-glutamyltranspeptidase; PDBTitle: crystal structure of escherichia coli gamma-glutamyltranspeptidase in2 complex with azaserine prepared in the dark Phyre2 PDB 4gdx chain A Region: 3 - 331 Aligned: 328 Modelled: 329 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:gamma-glutamyltranspeptidase 1 heavy chain; PDBTitle: crystal structure of human gamma-glutamyl transpeptidase--glutamate2 complex Phyre2 PDB 5zjg chain C Region: 3 - 330 Aligned: 324 Modelled: 328 Confidence: 100.0% Identity: 31% PDB header:transferase Chain: C: PDB Molecule:gamma-glutamyltransferase 1 threonine peptidase. merops PDBTitle: gamma-glutamyltranspeptidase from pseudomonas nitroreducens complexed2 with gly-gly Phyre2 PDB 3g9k chain D Region: 5 - 313 Aligned: 279 Modelled: 290 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: D: PDB Molecule:capsule biosynthesis protein capd; PDBTitle: crystal structure of bacillus anthracis transpeptidase enzyme capd Phyre2 PDB 2v36 chain D Region: 333 - 510 Aligned: 176 Modelled: 178 Confidence: 100.0% Identity: 29% PDB header:transferase Chain: D: PDB Molecule:gamma-glutamyltranspeptidase small chain; PDBTitle: crystal structure of gamma-glutamyl transferase from bacillus subtilis Phyre2 PDB 2e0y chain B Region: 333 - 510 Aligned: 175 Modelled: 178 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: B: PDB Molecule:gamma-glutamyltranspeptidase; PDBTitle: crystal structure of the samarium derivative of mature gamma-2 glutamyltranspeptidase from escherichia coli Phyre2 PDB 4gdx chain B Region: 333 - 511 Aligned: 177 Modelled: 179 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: B: PDB Molecule:gamma-glutamyltranspeptidase 1 light chain; PDBTitle: crystal structure of human gamma-glutamyl transpeptidase--glutamate2 complex Phyre2 PDB 5zjg chain D Region: 333 - 511 Aligned: 177 Modelled: 179 Confidence: 100.0% Identity: 29% PDB header:transferase Chain: D: PDB Molecule:gamma-glutamyltransferase 1 threonine peptidase. merops PDBTitle: gamma-glutamyltranspeptidase from pseudomonas nitroreducens complexed2 with gly-gly Phyre2 PDB 2nqo chain B Region: 333 - 505 Aligned: 173 Modelled: 173 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: B: PDB Molecule:gamma-glutamyltranspeptidase; PDBTitle: crystal structure of helicobacter pylori gamma-glutamyltranspeptidase Phyre2 PDB 3ga9 chain S Region: 333 - 509 Aligned: 162 Modelled: 175 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: S: PDB Molecule:capsule biosynthesis protein capd; PDBTitle: crystal structure of bacillus anthracis transpeptidase enzyme capd,2 crystal form ii Phyre2 PDB 1p4v chain A Region: 304 - 442 Aligned: 110 Modelled: 110 Confidence: 95.2% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:n(4)-(beta-n-acetylglucosaminyl)-l-asparaginase PDBTitle: crystal structure of the glycosylasparaginase precursor2 d151n mutant with glycine Phyre2 PDB 1apy chain A Region: 15 - 53 Aligned: 39 Modelled: 39 Confidence: 94.8% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:aspartylglucosaminidase; PDBTitle: human aspartylglucosaminidase Phyre2 PDB 1t3m chain A Region: 15 - 53 Aligned: 39 Modelled: 39 Confidence: 94.6% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:putative l-asparaginase; PDBTitle: structure of the isoaspartyl peptidase with l-asparaginase2 activity from e. coli Phyre2 PDB 3cuq chain A Region: 136 - 217 Aligned: 71 Modelled: 82 Confidence: 94.1% Identity: 20% PDB header:protein transport Chain: A: PDB Molecule:vacuolar-sorting protein snf8; PDBTitle: integrated structural and functional model of the human escrt-ii2 complex Phyre2 1 c4y23A_ 2 d2nlza1 3 d2i3oa1 4 c2e0wA_ 5 c2v36A_ 6 c2qm6C_ 7 c2z8jA_ 8 c4gdxA_ 9 c5zjgC_ 10 c3g9kD_ 11 c2v36D_ 12 c2e0yB_ 13 c4gdxB_ 14 c5zjgD_ 15 c2nqoB_ 16 c3ga9S_ 17 c1p4vA_ 18 c1apyA_ 19 c1t3mA_ 20 c3cuqA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99