1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	P	A	L	S	D	Y	Q	H	V	A	S	G	K	V	R	E	I	Y	R	V	D	D	E	H	L	L	L	V	A	S	D	R	I	S	A	Y	D	Y	V	L	D	S	T	I	P	D	K	G	R	V	L	T	A	M	S	A	F	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	G	L	V	D	A	P	N	H	L	A	G	P	P	D	D	P	R	I	P	D	E	V	L	G	R	A	L	V	V	R	R	L	E	M	L	P	V	E	C	V	A	R	G	Y	L	T	G	S	G	L	L	D	Y	Q	A	T	G	K	V
Secondary structure
SS confidence
Disorder																	?	?				?				?																															?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		C	G	I	A	L	P	P	G	L	V	E	A	S	R	F	A	T	P	L	F	T	P	A	T	K	A	A	L	G	D	H	D	E	N	I	S	F	D	R	V	V	E	M	V	G	A	L	R	A	N	Q	L	R	D	R	T	L	Q	T	Y
Secondary structure
SS confidence
Disorder		?	?									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	Q	A	A	D	H	A	L	T	R	G	I	I	I	A	D	T	K	F	E	F	G	I	D	R	H	G	N	L	L	L	A	D	E	I	F	T	P	D	S	S	R	Y	W	P	A	D	D	Y	R	A	G	V	V	Q	T	S	F	D	K
Secondary structure
SS confidence
Disorder																																																	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.
Sequence		Q	F	V	R	S	W	L	T	G	S	E	S	G	W	D	R	G	S	D	R	P	P	P	P	L	P	E	H	I	V	E	A	T	R	A	R	Y	I	N	A	Y	E	R	I	S	E	L	K	F	D	D	W	I	G	P	G	A
Secondary structure
SS confidence
Disorder												?				?	?	?	?	?	?	?	?																													?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 16%) Alpha helix ( 35%) Beta strand ( 22%)

Rank Aligned region

PDB 3r9r chain A Region: 1 - 295 Aligned: 293 Modelled: 295 Confidence: 100.0% Identity: 76% PDB header:ligase Chain: A: PDB Molecule:phosphoribosylaminoimidazole-succinocarboxamide synthase; PDBTitle: structure of a phosphoribosylaminoimidazole-succinocarboxamide2 synthase from mycobacterium abscessus atcc 19977 / dsm 44196 Phyre2 PDB 2cnq chain A domain 1 Region: 1 - 289 Aligned: 281 Modelled: 284 Confidence: 100.0% Identity: 44% Fold: SAICAR synthase-like Superfamily: SAICAR synthase-like Family: SAICAR synthase Phyre2 PDB 2z02 chain A Region: 4 - 284 Aligned: 228 Modelled: 249 Confidence: 100.0% Identity: 29% PDB header:ligase Chain: A: PDB Molecule:phosphoribosylaminoimidazole-succinocarboxamide PDBTitle: crystal structure of2 phosphoribosylaminoimidazolesuccinocarboxamide synthase3 wit atp from methanocaldococcus jannaschii Phyre2 PDB 2ywv chain B Region: 9 - 287 Aligned: 226 Modelled: 256 Confidence: 100.0% Identity: 29% PDB header:ligase Chain: B: PDB Molecule:phosphoribosylaminoimidazole succinocarboxamide synthetase; PDBTitle: crystal structure of saicar synthetase from geobacillus kaustophilus Phyre2 PDB 3kre chain A Region: 9 - 288 Aligned: 227 Modelled: 248 Confidence: 100.0% Identity: 23% PDB header:ligase Chain: A: PDB Molecule:phosphoribosylaminoimidazole-succinocarboxamide synthase; PDBTitle: crystal structure of phosphoribosylaminoimidazole-succinocarboxamide2 synthase from ehrlichia chaffeensis at 1.8a resolution Phyre2 PDB 2gqs chain A Region: 5 - 284 Aligned: 226 Modelled: 248 Confidence: 100.0% Identity: 28% PDB header:ligase Chain: A: PDB Molecule:phosphoribosylaminoimidazole-succinocarboxamide synthase; PDBTitle: saicar synthetase complexed with cair-mg2+ and adp Phyre2 PDB 3nua chain B Region: 3 - 284 Aligned: 228 Modelled: 259 Confidence: 100.0% Identity: 25% PDB header:ligase Chain: B: PDB Molecule:phosphoribosylaminoimidazole-succinocarboxamide synthase; PDBTitle: crystal structure of phosphoribosylaminoimidazole-succinocarboxamide2 synthase from clostridium perfringens Phyre2 PDB 3u54 chain B Region: 16 - 288 Aligned: 220 Modelled: 228 Confidence: 100.0% Identity: 30% PDB header:ligase Chain: B: PDB Molecule:phosphoribosylaminoimidazole-succinocarboxamide synthase; PDBTitle: crystal structure (type-1) of saicar synthetase from pyrococcus2 horikoshii ot3 Phyre2 PDB 4fe2 chain B Region: 7 - 288 Aligned: 228 Modelled: 250 Confidence: 100.0% Identity: 30% PDB header:ligase Chain: B: PDB Molecule:phosphoribosylaminoimidazole-succinocarboxamide synthase; PDBTitle: x-ray structure of saicar synthetase (purc) from streptococcus2 pneumoniae complexed with air, adp, asp and mg2+ Phyre2 PDB 4ja0 chain A Region: 9 - 288 Aligned: 235 Modelled: 264 Confidence: 100.0% Identity: 27% PDB header:protein binding Chain: A: PDB Molecule:phosphoribosylaminoimidazole carboxylase; PDBTitle: crystal structure of the invertebrate bi-functional purine2 biosynthesis enzyme paics at 2.8 a resolution Phyre2 PDB 1kut chain A Region: 16 - 288 Aligned: 206 Modelled: 240 Confidence: 100.0% Identity: 29% Fold: SAICAR synthase-like Superfamily: SAICAR synthase-like Family: SAICAR synthase Phyre2 PDB 2h31 chain A Region: 5 - 238 Aligned: 197 Modelled: 234 Confidence: 100.0% Identity: 26% PDB header:ligase, lyase Chain: A: PDB Molecule:multifunctional protein ade2; PDBTitle: crystal structure of human paics, a bifunctional carboxylase and2 synthetase in purine biosynthesis Phyre2 PDB 2bcg chain G domain 2 Region: 271 - 291 Aligned: 21 Modelled: 21 Confidence: 57.9% Identity: 14% Fold: FAD/NAD(P)-binding domain Superfamily: FAD/NAD(P)-binding domain Family: GDI-like N domain Phyre2 PDB 6g51 chain V Region: 172 - 213 Aligned: 41 Modelled: 42 Confidence: 32.2% Identity: 12% PDB header:ribosome Chain: V: PDB Molecule:40s ribosomal protein s21; PDBTitle: cryo-em structure of a late human pre-40s ribosomal subunit - state d Phyre2 PDB 4im2 chain A Region: 170 - 296 Aligned: 91 Modelled: 100 Confidence: 29.2% Identity: 12% PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:serine/threonine-protein kinase tbk1; PDBTitle: structure of tank-binding kinase 1 Phyre2 PDB 1zp9 chain A Region: 172 - 213 Aligned: 41 Modelled: 42 Confidence: 27.7% Identity: 7% PDB header:transferase Chain: A: PDB Molecule:rio1 kinase; PDBTitle: crystal structure of full-legnth a.fulgidus rio1 serine kinase bound2 to atp and mn2+ ions. Phyre2 PDB 4l8n chain A Region: 218 - 230 Aligned: 13 Modelled: 13 Confidence: 25.4% Identity: 15% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:pdz domain protein; PDBTitle: crystal structure of a pdz domain protein (bdi_1242) from2 parabacteroides distasonis atcc 8503 at 2.50 a resolution Phyre2 PDB 5hb8 chain B Region: 97 - 120 Aligned: 24 Modelled: 24 Confidence: 24.8% Identity: 46% PDB header:transport protein Chain: B: PDB Molecule:nucleoporin nup53; PDBTitle: crystal structure of chaetomium thermophilum nup53 rrm (space group2 p3121) Phyre2 PDB 2r7k chain A domain 2 Region: 164 - 218 Aligned: 49 Modelled: 54 Confidence: 23.5% Identity: 10% Fold: ATP-grasp Superfamily: Glutathione synthetase ATP-binding domain-like Family: PurP ATP-binding domain-like Phyre2 PDB 5c4i chain C Region: 220 - 284 Aligned: 56 Modelled: 65 Confidence: 21.7% Identity: 14% PDB header:oxidoreductase Chain: C: PDB Molecule:oxalate oxidoreductase subunit beta; PDBTitle: structure of an oxalate oxidoreductase Phyre2 1 c3r9rA_ 2 d2cnqa1 3 c2z02A_ 4 c2ywvB_ 5 c3kreA_ 6 c2gqsA_ 7 c3nuaB_ 8 c3u54B_ 9 c4fe2B_ 10 c4ja0A_ 11 d1kuta_ 12 c2h31A_ 13 d2bcgg2 14 c6g51v_ 15 c4im2A_ 16 c1zp9A_ 17 c4l8nA_ 18 c5hb8B_ 19 d2r7ka2 20 c5c4iC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78