1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	A	T	A	H	G	L	C	E	F	I	D	A	S	P	S	P	F	H	V	C	A	T	V	A	G	R	L	L	G	A	G	Y	R	E	L	R	E	A	D	R	W	P	D	K	P	G	R	Y	F	T	V	R	A	G	S	L	V	A
Secondary structure
SS confidence
Disorder		?																																	?	?		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		W	N	A	E	Q	S	G	H	T	Q	V	P	F	R	I	V	G	A	H	T	D	S	P	N	L	R	V	K	Q	H	P	D	R	L	V	A	G	W	H	V	V	A	L	Q	P	Y	G	G	V	W	L	H	S	W	L	D	R	D	L	G
Secondary structure
SS confidence
Disorder						?				?																				?	?		?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	S	G	R	L	S	V	R	D	G	T	G	V	S	H	R	L	V	L	I	D	D	P	I	L	R	V	P	Q	L	A	I	H	L	A	E	D	R	K	S	L	T	L	D	P	Q	R	H	I	N	A	V	W	G	V	G	E	R	V	E
Secondary structure
SS confidence
Disorder																																		?				?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	F	V	G	Y	V	A	Q	R	A	G	V	A	A	A	D	V	L	A	A	D	L	M	T	H	D	L	T	P	S	A	L	I	G	A	S	V	N	G	T	A	S	L	L	S	A	P	R	L	D	N	Q	A	S	C	Y	A	G	M	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	L	L	A	V	D	V	D	S	A	S	S	G	F	V	P	V	L	A	I	F	D	H	E	E	V	G	S	A	S	G	H	G	A	Q	S	D	L	L	S	S	V	L	E	R	I	V	L	A	A	G	G	T	R	E	D	F	L	R	R
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?																			?	?				?	?														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	T	T	S	M	L	A	S	A	D	M	A	H	A	T	H	P	N	Y	P	D	R	H	E	P	S	H	P	I	E	V	N	A	G	P	V	L	K	V	H	P	N	L	R	Y	A	T	D	G	R	T	A	A	A	F	A	L	A	C	Q
Secondary structure
SS confidence
Disorder																																										?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	A	G	V	P	M	Q	R	Y	E	H	R	A	D	L	P	C	G	S	T	I	G	P	L	A	A	A	R	T	G	I	P	T	V	D	V	G	A	A	Q	L	A	M	H	S	A	R	E	L	M	G	A	H	D	V	A	A	Y	S	A
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.
Sequence		A	L	Q	A	F	L	S	A	E	L	S	E	A
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 29%) Beta strand ( 28%)

Rank Aligned region

PDB 3l6s chain A Region: 1 - 428 Aligned: 423 Modelled: 428 Confidence: 100.0% Identity: 36% PDB header:hydrolase Chain: A: PDB Molecule:aspartyl aminopeptidase; PDBTitle: crystal structure of human aspartyl aminopeptidase (dnpep), in complex2 with aspartic acid hydroxamate Phyre2 PDB 4eme chain B Region: 2 - 427 Aligned: 420 Modelled: 426 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: B: PDB Molecule:m18 aspartyl aminopeptidase; PDBTitle: x-ray crystal structure and specificity of the plasmodium falciparum2 malaria aminopeptidase Phyre2 PDB 2glf chain B Region: 1 - 427 Aligned: 415 Modelled: 422 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:probable m18-family aminopeptidase 1; PDBTitle: crystal structure of aminipeptidase (m18 family) from thermotoga2 maritima Phyre2 PDB 2glj chain R Region: 1 - 428 Aligned: 414 Modelled: 428 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: R: PDB Molecule: PDBTitle: crystal structure of aminopeptidase i from clostridium2 acetobutylicum Phyre2 PDB 5jm6 chain D Region: 1 - 427 Aligned: 406 Modelled: 427 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: D: PDB Molecule:aminopeptidase-like protein; PDBTitle: structure of chaetomium thermophilum mape1 Phyre2 PDB 4r8f chain B Region: 1 - 427 Aligned: 405 Modelled: 427 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: B: PDB Molecule:vacuolar aminopeptidase 1; PDBTitle: crystal structure of yeast aminopeptidase 1 (ape1) Phyre2 PDB 3var chain A Region: 1 - 428 Aligned: 391 Modelled: 428 Confidence: 100.0% Identity: 39% PDB header:hydrolase Chain: A: PDB Molecule:aspartyl aminopeptidase; PDBTitle: crystal structure of dnpep, znzn form Phyre2 PDB 1y7e chain A Region: 1 - 427 Aligned: 387 Modelled: 418 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:probable m18-family aminopeptidase 1; PDBTitle: the crystal structure of aminopeptidase i from borrelia burgdorferi2 b31 Phyre2 PDB 2ijz chain F Region: 8 - 428 Aligned: 377 Modelled: 408 Confidence: 100.0% Identity: 43% PDB header:hydrolase Chain: F: PDB Molecule:probable m18-family aminopeptidase 2; PDBTitle: crystal structure of aminopeptidase Phyre2 PDB 1y7e chain A domain 2 Region: 1 - 427 Aligned: 276 Modelled: 298 Confidence: 100.0% Identity: 24% Fold: Phosphorylase/hydrolase-like Superfamily: Zn-dependent exopeptidases Family: Bacterial dinuclear zinc exopeptidases Phyre2 PDB 2gre chain C Region: 5 - 432 Aligned: 299 Modelled: 360 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: C: PDB Molecule:deblocking aminopeptidase; PDBTitle: crystal structure of deblocking aminopeptidase from bacillus cereus Phyre2 PDB 1y0y chain A domain 2 Region: 212 - 428 Aligned: 184 Modelled: 194 Confidence: 100.0% Identity: 17% Fold: Phosphorylase/hydrolase-like Superfamily: Zn-dependent exopeptidases Family: Bacterial dinuclear zinc exopeptidases Phyre2 PDB 1ylo chain A domain 2 Region: 7 - 428 Aligned: 244 Modelled: 251 Confidence: 100.0% Identity: 20% Fold: Phosphorylase/hydrolase-like Superfamily: Zn-dependent exopeptidases Family: Bacterial dinuclear zinc exopeptidases Phyre2 PDB 1xfo chain A domain 2 Region: 7 - 433 Aligned: 246 Modelled: 260 Confidence: 100.0% Identity: 19% Fold: Phosphorylase/hydrolase-like Superfamily: Zn-dependent exopeptidases Family: Bacterial dinuclear zinc exopeptidases Phyre2 PDB 3kl9 chain F Region: 1 - 432 Aligned: 327 Modelled: 365 Confidence: 99.9% Identity: 19% PDB header:hydrolase Chain: F: PDB Molecule:glutamyl aminopeptidase; PDBTitle: crystal structure of pepa from streptococcus pneumoniae Phyre2 PDB 2pe3 chain A Region: 7 - 432 Aligned: 318 Modelled: 365 Confidence: 99.9% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:354aa long hypothetical operon protein frv; PDBTitle: crystal structure of frv operon protein frvx (ph1821)from pyrococcus2 horikoshii ot3 Phyre2 PDB 1y7e chain A domain 1 Region: 85 - 204 Aligned: 110 Modelled: 120 Confidence: 99.9% Identity: 18% Fold: Domain of alpha and beta subunits of F1 ATP synthase-like Superfamily: Aminopeptidase/glucanase lid domain Family: Aminopeptidase/glucanase lid domain Phyre2 PDB 2cf4 chain A Region: 7 - 428 Aligned: 322 Modelled: 380 Confidence: 99.9% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:protein ph0519; PDBTitle: pyrococcus horikoshii tet1 peptidase can assemble into a2 tetrahedron or a large octahedral shell Phyre2 PDB 1vhe chain A domain 2 Region: 1 - 427 Aligned: 252 Modelled: 263 Confidence: 99.9% Identity: 19% Fold: Phosphorylase/hydrolase-like Superfamily: Zn-dependent exopeptidases Family: Bacterial dinuclear zinc exopeptidases Phyre2 PDB 4wwv chain A Region: 7 - 433 Aligned: 336 Modelled: 366 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase from family m42; PDBTitle: aminopeptidase apdkam598 from the archaeon desulfurococcus2 kamchatkensis Phyre2 1 c3l6sA_ 2 c4emeB_ 3 c2glfB_ 4 c2gljR_ 5 c5jm6D_ 6 c4r8fB_ 7 c3varA_ 8 c1y7eA_ 9 c2ijzF_ 10 d1y7ea2 11 c2greC_ 12 d1y0ya2 13 d1yloa2 14 d1xfoa2 15 c3kl9F_ 16 c2pe3A_ 17 d1y7ea1 18 c2cf4A_ 19 d1vhea2 20 c4wwvA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121