1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	R	L	R	A	L	S	L	A	A	G	L	V	G	W	S	L	V	S	P	R	L	P	A	P	W	R	I	P	L	Q	A	G	L	G	S	V	L	V	L	V	T	R	A	T	M	G	L	W	P	P	R	L	W	A	G	L	R	L
Secondary structure
SS confidence
Disorder		?	?	?																			?	?	?	?	?	?	?	?	?												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	W	A	A	G	A	A	A	A	T	A	I	A	A	T	T	P	V	P	M	V	R	L	S	M	S	A	R	E	L	P	A	S	V	P	V	W	L	V	W	H	I	P	G	G	T	V	W	A	E	E	A	A	F	R	G	A	L	A	T
Secondary structure
SS confidence
Disorder																?	?	?	?	?					?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	G	A	R	A	F	G	R	S	G	G	R	I	L	Q	A	G	A	F	G	L	S	H	I	A	D	A	R	A	T	G	E	P	L	V	L	T	V	L	A	T	G	I	A	G	W	M	F	G	W	L	A	D	R	S	G	S	L	A	A
Secondary structure
SS confidence
Disorder																												?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.
Sequence		P	L	L	T	H	L	A	I	N	E	A	G	A	V	A	A	V	L	V	Q	R	R	S	G	I	S	T	R	L
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 21%) Alpha helix ( 86%) Beta strand ( 0%) TM helix ( 47%) (View membrane topology prediction)

Rank Aligned region

PDB 4cad chain C Region: 29 - 194 Aligned: 166 Modelled: 166 Confidence: 100.0% Identity: 12% PDB header:protein binding Chain: C: PDB Molecule:ras and a-factor converting enzyme 1, rce1; PDBTitle: mechanism of farnesylated caax protein processing by the integral2 membrane protease rce1 Phyre2 PDB 4cad chain F Region: 20 - 194 Aligned: 175 Modelled: 175 Confidence: 99.9% Identity: 11% PDB header:protein binding Chain: F: PDB Molecule:ras and a-factor converting enzyme 1, rce1; PDBTitle: mechanism of farnesylated caax protein processing by the integral2 membrane protease rce1 Phyre2 PDB 5wwo chain B Region: 110 - 138 Aligned: 29 Modelled: 29 Confidence: 57.0% Identity: 17% PDB header:rna binding protein Chain: B: PDB Molecule:essential nuclear protein 1; PDBTitle: crystal structure of enp1 Phyre2 PDB 6g4w chain W Region: 110 - 138 Aligned: 29 Modelled: 29 Confidence: 26.4% Identity: 17% PDB header:ribosome Chain: W: PDB Molecule:40s ribosomal protein s15a; PDBTitle: cryo-em structure of a late human pre-40s ribosomal subunit - state a Phyre2 PDB 4z7f chain D Region: 126 - 184 Aligned: 57 Modelled: 59 Confidence: 19.4% Identity: 18% PDB header:transport protein Chain: D: PDB Molecule:folate ecf transporter; PDBTitle: crystal structure of folt bound with folic acid Phyre2 1 c4cadC_ 2 c4cadF_ 3 c5wwoB_ 4 c6g4ww_ 5 c4z7fD_