1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	H	R	L	R	A	A	E	H	P	R	P	D	Y	V	L	L	H	I	S	D	T	H	L	I	G	G	D	R	R	L	Y	G	A	V	D	A	D	D	R	L	G	E	L	L	E	Q	L	N	Q	S	G	L	R	P	D	A	I	V	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?																				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	G	D	L	A	D	K	G	E	P	A	A	Y	R	K	L	R	G	L	V	E	P	F	A	A	Q	L	G	A	E	L	V	W	V	M	G	N	H	D	D	R	A	E	L	R	K	F	L	L	D	E	A	P	S	M	A	P	L	D	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	C	M	I	D	G	L	R	I	I	V	L	D	T	S	V	P	G	H	H	H	G	E	I	R	A	S	Q	L	G	W	L	A	E	E	L	A	T	P	A	P	D	G	T	I	L	A	L	H	H	P	P	I	P	S	V	L	D	M	A
Secondary structure
SS confidence
Disorder																					?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	T	V	E	L	R	D	Q	A	A	L	G	R	V	L	R	G	T	D	V	R	A	I	L	A	G	H	L	H	Y	S	T	N	A	T	F	V	G	I	P	V	S	V	A	S	A	T	C	Y	T	Q	D	L	T	V	A	A	G	G	T
Secondary structure
SS confidence
Disorder																																																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	G	R	D	G	A	Q	G	C	N	L	V	H	V	Y	P	D	T	V	V	H	S	V	I	P	L	G	G	G	E	T	V	G	T	F	V	S	P	G	Q	A	R	R	K	I	A	E	S	G	I	F	I	E	P	S	R	R	D	S	L
Secondary structure
SS confidence
Disorder		?	?	?																																					?	?	?	?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.
Sequence		F	K	H	P	P	M	V	L	T	S	S	A	P	R	S	P	V	D
Secondary structure
SS confidence
Disorder					?	?	?		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 25%) Beta strand ( 23%)

Rank Aligned region

PDB 3ib7 chain A Region: 4 - 298 Aligned: 295 Modelled: 295 Confidence: 100.0% Identity: 100% PDB header:hydrolase Chain: A: PDB Molecule:icc protein; PDBTitle: crystal structure of full length rv0805 Phyre2 PDB 3d03 chain A domain 1 Region: 15 - 270 Aligned: 252 Modelled: 256 Confidence: 100.0% Identity: 24% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: GpdQ-like Phyre2 PDB 2hy1 chain A Region: 10 - 265 Aligned: 227 Modelled: 237 Confidence: 100.0% Identity: 100% PDB header:hydrolase Chain: A: PDB Molecule:rv0805; PDBTitle: crystal structure of rv0805 Phyre2 PDB 2hy1 chain A domain 1 Region: 10 - 265 Aligned: 227 Modelled: 237 Confidence: 100.0% Identity: 100% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: GpdQ-like Phyre2 PDB 2xmo chain B Region: 10 - 267 Aligned: 240 Modelled: 243 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:lmo2642 protein; PDBTitle: the crystal structure of lmo2642 Phyre2 PDB 4lty chain D Region: 15 - 287 Aligned: 261 Modelled: 272 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: D: PDB Molecule:exonuclease subunit sbcd; PDBTitle: crystal structure of e.coli sbcd at 1.8 a resolution Phyre2 PDB 4yke chain A Region: 14 - 271 Aligned: 239 Modelled: 258 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:mre11; PDBTitle: crystal structure of eukaryotic mre11 catalytic domain from chaetomium2 thermophilum Phyre2 PDB 4fcx chain B Region: 14 - 271 Aligned: 239 Modelled: 256 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:dna repair protein rad32; PDBTitle: s.pombe mre11 apoenzym Phyre2 PDB 3av0 chain A Region: 15 - 266 Aligned: 226 Modelled: 252 Confidence: 100.0% Identity: 17% PDB header:recombination Chain: A: PDB Molecule:dna double-strand break repair protein mre11; PDBTitle: crystal structure of mre11-rad50 bound to atp s Phyre2 PDB 2q8u chain A Region: 11 - 277 Aligned: 245 Modelled: 266 Confidence: 100.0% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:exonuclease, putative; PDBTitle: crystal structure of mre11 from thermotoga maritima msb8 (tm1635) at2 2.20 a resolution Phyre2 PDB 4fbk chain B Region: 14 - 271 Aligned: 239 Modelled: 258 Confidence: 100.0% Identity: 17% PDB header:hydrolase, protein binding Chain: B: PDB Molecule:dna repair and telomere maintenance protein nbs1,dna repair PDBTitle: crystal structure of a covalently fused nbs1-mre11 complex with one2 manganese ion per active site Phyre2 PDB 3t1i chain C Region: 14 - 271 Aligned: 239 Modelled: 256 Confidence: 100.0% Identity: 15% PDB header:hydrolase Chain: C: PDB Molecule:double-strand break repair protein mre11a; PDBTitle: crystal structure of human mre11: understanding tumorigenic mutations Phyre2 PDB 2nxf chain A domain 1 Region: 12 - 271 Aligned: 244 Modelled: 248 Confidence: 100.0% Identity: 21% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: ADPRibase-Mn-like Phyre2 PDB 3qg5 chain D Region: 15 - 277 Aligned: 245 Modelled: 253 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: D: PDB Molecule:mre11; PDBTitle: the mre11:rad50 complex forms an atp dependent molecular clamp in dna2 double-strand break repair Phyre2 PDB 3auz chain A Region: 15 - 271 Aligned: 233 Modelled: 248 Confidence: 100.0% Identity: 18% PDB header:recombination Chain: A: PDB Molecule:dna double-strand break repair protein mre11; PDBTitle: crystal structure of mre11 with manganese Phyre2 PDB 5ebb chain A Region: 10 - 258 Aligned: 243 Modelled: 243 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:acid sphingomyelinase-like phosphodiesterase 3a; PDBTitle: structure of human sphingomyelinase phosphodiesterase like 3a2 (smpdl3a) with zn2+ Phyre2 PDB 5kar chain A Region: 15 - 258 Aligned: 241 Modelled: 241 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:acid sphingomyelinase-like phosphodiesterase 3b; PDBTitle: murine acid sphingomyelinase-like phosphodiesterase 3b (smpdl3b) Phyre2 PDB 1ii7 chain A Region: 15 - 252 Aligned: 221 Modelled: 237 Confidence: 99.9% Identity: 17% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: DNA double-strand break repair nuclease Phyre2 PDB 1ute chain A Region: 10 - 276 Aligned: 260 Modelled: 267 Confidence: 99.9% Identity: 18% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: Purple acid phosphatase-like Phyre2 PDB 1xzw chain A domain 2 Region: 9 - 261 Aligned: 234 Modelled: 253 Confidence: 99.9% Identity: 20% Fold: Metallo-dependent phosphatases Superfamily: Metallo-dependent phosphatases Family: Purple acid phosphatase-like Phyre2 1 c3ib7A_ 2 d3d03a1 3 c2hy1A_ 4 d2hy1a1 5 c2xmoB_ 6 c4ltyD_ 7 c4ykeA_ 8 c4fcxB_ 9 c3av0A_ 10 c2q8uA_ 11 c4fbkB_ 12 c3t1iC_ 13 d2nxfa1 14 c3qg5D_ 15 c3auzA_ 16 c5ebbA_ 17 c5karA_ 18 d1ii7a_ 19 d1utea_ 20 d1xzwa2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171