1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	A	V	P	A	P	D	P	G	P	D	A	G	A	I	W	H	Y	G	D	P	L	G	E	Q	R	A	G	Q	A	D	A	V	L	V	D	R	S	H	R	A	V	L	T	L	D	G	G	D	R	Q	T	W	L	H	S	I	S	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	H	V	S	D	L	P	E	G	A	S	T	Q	N	L	S	L	D	G	Q	G	R	V	E	D	H	W	I	Q	T	E	L	G	G	T	T	Y	L	D	T	E	P	W	R	G	E	P	L	L	A	Y	L	R	K	M	V	F	W	S	M
Secondary structure
SS confidence
Disorder								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	T	P	R	A	A	D	M	A	V	L	S	L	L	G	P	R	L	A	E	E	R	V	L	D	A	L	G	L	D	V	L	P	A	E	W	L	A	V	P	L	A	G	G	G	I	V	R	R	M	P	D	G	L	A	G	Q	I	E	L
Secondary structure
SS confidence
Disorder																								?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	V	V	V	K	R	G	D	R	A	D	W	Q	R	R	L	T	Q	A	G	V	R	P	A	G	I	W	A	Y	E	A	H	R	V	A	H	R	V	P	A	R	R	P	R	L	G	V	D	T	D	E	R	T	I	P	H	E	V	G	W
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	G	G	P	G	A	G	A	V	H	L	N	K	G	C	Y	R	G	Q	E	T	V	A	R	V	H	N	L	G	R	P	P	R	M	L	V	L	L	H	L	D	E	S	V	Q	R	P	S	T	G	D	A	V	L	A	G	G	R	T	V
Secondary structure
SS confidence
Disorder						?	?																						?															?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	R	L	G	T	V	V	E	H	V	E	L	G	P	V	A	L	A	L	L	K	R	G	L	P	G	D	T	A	L	V	T	G	P	E	A	E	V	A	A	V	I	D	V	D	S	L	P	P	A	D	D	V	G	A	G	R	R	A	V
Secondary structure
SS confidence
Disorder																																				?	?	?											?	?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.
Sequence		E	R	L	R	G	G	I	R
Secondary structure
SS confidence
Disorder					?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 24%) Beta strand ( 29%)

Rank Aligned region

PDB 1pj6 chain A Region: 7 - 356 Aligned: 339 Modelled: 350 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: A: PDB Molecule:n,n-dimethylglycine oxidase; PDBTitle: crystal structure of dimethylglycine oxidase of arthrobacter2 globiformis in complex with folic acid Phyre2 PDB 4p9s chain A Region: 4 - 362 Aligned: 346 Modelled: 355 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:dimethylglycine dehydrogenase; PDBTitle: crystal structure of the mature form of rat dmgdh Phyre2 PDB 3gir chain A Region: 15 - 350 Aligned: 326 Modelled: 336 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:aminomethyltransferase; PDBTitle: crystal structure of glycine cleavage system2 aminomethyltransferase t from bartonella henselae Phyre2 PDB 1wor chain A Region: 15 - 355 Aligned: 328 Modelled: 341 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:aminomethyltransferase; PDBTitle: crystal structure of t-protein of the glycine cleavage2 system Phyre2 PDB 1x31 chain A Region: 16 - 357 Aligned: 332 Modelled: 342 Confidence: 100.0% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:sarcosine oxidase alpha subunit; PDBTitle: crystal structure of heterotetrameric sarcosine oxidase from2 corynebacterium sp. u-96 Phyre2 PDB 1vlo chain A Region: 13 - 354 Aligned: 332 Modelled: 341 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:aminomethyltransferase; PDBTitle: crystal structure of aminomethyltransferase (t protein;2 tetrahydrofolate-dependent) of glycine cleavage system (np417381)3 from escherichia coli k12 at 1.70 a resolution Phyre2 PDB 1v5v chain A Region: 15 - 350 Aligned: 324 Modelled: 336 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:aminomethyltransferase; PDBTitle: crystal structure of a component of glycine cleavage system: t-protein2 from pyrococcus horikoshii ot3 at 1.5 a resolution Phyre2 PDB 1wsr chain A Region: 15 - 350 Aligned: 328 Modelled: 336 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:aminomethyltransferase; PDBTitle: crystal structure of human t-protein of glycine cleavage2 system Phyre2 PDB 1yx2 chain B Region: 15 - 352 Aligned: 327 Modelled: 338 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:aminomethyltransferase; PDBTitle: crystal structure of the probable aminomethyltransferase2 from bacillus subtilis Phyre2 PDB 3tfh chain B Region: 15 - 349 Aligned: 325 Modelled: 335 Confidence: 100.0% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:gcvt-like aminomethyltransferase protein; PDBTitle: dmsp-dependent demethylase from p. ubique - apo Phyre2 PDB 5tl4 chain C Region: 15 - 354 Aligned: 326 Modelled: 340 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: C: PDB Molecule:vanillate/3-o-methylgallate o-demethylase; PDBTitle: crystal structure of sphingomonas paucimobilis aryl o-demethylase ligm Phyre2 PDB 1vly chain A Region: 29 - 350 Aligned: 304 Modelled: 317 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:unknown protein from 2d-page; PDBTitle: crystal structure of a putative aminomethyltransferase (ygfz) from2 escherichia coli at 1.30 a resolution Phyre2 PDB 5oli chain A Region: 34 - 348 Aligned: 284 Modelled: 311 Confidence: 100.0% Identity: 21% PDB header:protein binding Chain: A: PDB Molecule:putative transferase caf17, mitochondrial; PDBTitle: crystal structure of human iba57 Phyre2 PDB 1vlo chain A domain 2 Region: 15 - 269 Aligned: 248 Modelled: 251 Confidence: 100.0% Identity: 20% Fold: Folate-binding domain Superfamily: Folate-binding domain Family: Aminomethyltransferase folate-binding domain Phyre2 PDB 1wos chain A domain 2 Region: 15 - 268 Aligned: 244 Modelled: 254 Confidence: 100.0% Identity: 19% Fold: Folate-binding domain Superfamily: Folate-binding domain Family: Aminomethyltransferase folate-binding domain Phyre2 PDB 1pj5 chain A domain 4 Region: 6 - 270 Aligned: 255 Modelled: 265 Confidence: 100.0% Identity: 20% Fold: Folate-binding domain Superfamily: Folate-binding domain Family: Aminomethyltransferase folate-binding domain Phyre2 PDB 1v5v chain A domain 2 Region: 15 - 270 Aligned: 246 Modelled: 256 Confidence: 100.0% Identity: 18% Fold: Folate-binding domain Superfamily: Folate-binding domain Family: Aminomethyltransferase folate-binding domain Phyre2 PDB 1vly chain A domain 2 Region: 16 - 270 Aligned: 238 Modelled: 255 Confidence: 100.0% Identity: 18% Fold: Folate-binding domain Superfamily: Folate-binding domain Family: Aminomethyltransferase folate-binding domain Phyre2 PDB 2gag chain C Region: 11 - 204 Aligned: 184 Modelled: 194 Confidence: 99.9% Identity: 13% PDB header:oxidoreductase Chain: C: PDB Molecule:heterotetrameric sarcosine oxidase gamma-subunit; PDBTitle: heteroteterameric sarcosine: structure of a diflavin metaloenzyme at2 1.85 a resolution Phyre2 PDB 1pj5 chain A domain 1 Region: 273 - 356 Aligned: 84 Modelled: 84 Confidence: 99.4% Identity: 17% Fold: Elongation factor/aminomethyltransferase common domain Superfamily: Aminomethyltransferase beta-barrel domain Family: Aminomethyltransferase beta-barrel domain Phyre2 1 c1pj6A_ 2 c4p9sA_ 3 c3girA_ 4 c1worA_ 5 c1x31A_ 6 c1vloA_ 7 c1v5vA_ 8 c1wsrA_ 9 c1yx2B_ 10 c3tfhB_ 11 c5tl4C_ 12 c1vlyA_ 13 c5oliA_ 14 d1vloa2 15 d1wosa2 16 d1pj5a4 17 d1v5va2 18 d1vlya2 19 c2gagC_ 20 d1pj5a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73