1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	A	K	L	T	D	L	Q	L	L	H	E	L	E	P	V	V	E	K	Y	L	N	R	H	L	S	M	H	K	P	W	N	P	H	D	Y	I	P	W	S	D	G	K	N	Y	Y	A	L	G	G	Q	D	W	D	P	D	Q	S	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																																																		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	S	D	V	A	Q	V	A	M	V	Q	N	L	V	T	E	D	N	L	P	S	Y	H	R	E	I	A	M	N	M	G	M	D	G	A	W	G	Q	W	V	N	R	W	T	A	E	E	N	R	H	G	I	A	L	R	D	Y	L	V	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	R	S	V	D	P	V	E	L	E	K	L	R	L	E	V	V	N	R	G	F	S	P	G	Q	N	H	Q	G	H	Y	F	A	E	S	L	T	D	S	V	L	Y	V	S	F	Q	E	L	A	T	R	I	S	H	R	N	T	G	K	A
Secondary structure
SS confidence
Disorder																													?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		C	N	D	P	V	A	D	Q	L	M	A	K	I	S	A	D	E	N	L	H	M	I	F	Y	R	D	V	S	E	A	A	F	D	L	V	P	N	Q	A	M	K	S	L	H	L	I	L	S	H	F	Q	M	P	G	F	Q	V	P	E	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	R	K	A	V	V	I	A	V	G	G	V	Y	D	P	R	I	H	L	D	E	V	V	M	P	V	L	K	K	W	R	I	F	E	R	E	D	F	T	G	E	G	A	K	L	R	D	E	L	A	L	V	I	K	D	L	E	L	A	C
Secondary structure
SS confidence
Disorder																																		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.
Sequence		D	K	F	E	V	S	K	Q	R	Q	L	D	R	E	A	R	T	G	K	K	V	S	A	H	E	L	H	K	T	A	G	K	L	A	M	S	R	R
Secondary structure
SS confidence
Disorder									?	?	?	?								?	?								?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 74%) Beta strand ( 0%)

Rank Aligned region

PDB 1afr chain A Region: 1 - 302 Aligned: 291 Modelled: 302 Confidence: 100.0% Identity: 26% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1za0 chain A domain 1 Region: 9 - 278 Aligned: 236 Modelled: 237 Confidence: 100.0% Identity: 32% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1r2f chain B Region: 16 - 275 Aligned: 238 Modelled: 260 Confidence: 98.5% Identity: 13% PDB header:oxidoreductase Chain: B: PDB Molecule:protein (ribonucleotide reductase r2); PDBTitle: ribonucleotide reductase r2f protein from salmonella2 typhimurium Phyre2 PDB 1r2f chain A Region: 16 - 275 Aligned: 238 Modelled: 260 Confidence: 98.5% Identity: 13% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 4bmt chain B Region: 16 - 275 Aligned: 244 Modelled: 260 Confidence: 98.5% Identity: 10% PDB header:oxidoreductase Chain: B: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: crystal structure of ribonucleotide reductase di-iron nrdf2 from bacillus cereus Phyre2 PDB 5hyh chain A Region: 10 - 265 Aligned: 243 Modelled: 256 Confidence: 98.4% Identity: 17% PDB header:metal binding protein Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: cmli (chemically reduced state), arylamine oxygenase of2 chloramphenicol biosynthetic pathway Phyre2 PDB 1uzr chain A Region: 16 - 275 Aligned: 234 Modelled: 260 Confidence: 98.4% Identity: 12% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1sms chain A Region: 16 - 275 Aligned: 231 Modelled: 250 Confidence: 98.4% Identity: 13% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 3hf1 chain B Region: 16 - 275 Aligned: 232 Modelled: 259 Confidence: 98.4% Identity: 14% PDB header:oxidoreductase Chain: B: PDB Molecule:ribonucleoside-diphosphate reductase subunit m2 b; PDBTitle: crystal structure of human p53r2 Phyre2 PDB 1w68 chain A Region: 16 - 275 Aligned: 235 Modelled: 254 Confidence: 98.4% Identity: 13% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 2rcc chain C Region: 16 - 275 Aligned: 243 Modelled: 257 Confidence: 98.4% Identity: 13% PDB header:oxidoreductase Chain: C: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: crystal structure of putative class i ribonucleotide reductase2 (np_241368.1) from bacillus halodurans at 1.90 a resolution Phyre2 PDB 4hr0 chain A Region: 32 - 248 Aligned: 203 Modelled: 217 Confidence: 98.4% Identity: 12% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonuleotide reductase small subunit; PDBTitle: r2-like ligand-binding oxidase with aerobically reconstituted metal2 cofactor Phyre2 PDB 2p1i chain A Region: 16 - 225 Aligned: 185 Modelled: 201 Confidence: 98.4% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleotide reductase, small chain; PDBTitle: plasmodium yoelii ribonucleotide reductase subunit r2 (py03671) Phyre2 PDB 3cht chain A Region: 29 - 274 Aligned: 233 Modelled: 246 Confidence: 98.3% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:p-aminobenzoate n-oxygenase; PDBTitle: crystal structure of di-iron aurf with partially bound ligand Phyre2 PDB 1oqu chain C Region: 16 - 275 Aligned: 236 Modelled: 260 Confidence: 98.3% Identity: 8% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 3ee4 chain A Region: 32 - 280 Aligned: 236 Modelled: 244 Confidence: 98.2% Identity: 11% PDB header:oxidoreductase Chain: A: PDB Molecule:probable ribonucleoside-diphosphate reductase; PDBTitle: r2-like ligand binding mn/fe oxidase from m. tuberculosis Phyre2 PDB 2o1z chain A Region: 16 - 227 Aligned: 185 Modelled: 212 Confidence: 98.2% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleotide reductase subunit r2; PDBTitle: plasmodium vivax ribonucleotide reductase subunit r2 (pv086155) Phyre2 PDB 1h0o chain A Region: 16 - 227 Aligned: 190 Modelled: 212 Confidence: 98.2% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase; PDBTitle: cobalt substitution of mouse r2 ribonucleotide reductase to2 model the reactive diferrous state Phyre2 PDB 1jk0 chain B Region: 16 - 225 Aligned: 183 Modelled: 198 Confidence: 98.2% Identity: 9% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 4n83 chain F Region: 16 - 229 Aligned: 190 Modelled: 214 Confidence: 98.2% Identity: 13% PDB header:oxidoreductase Chain: F: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: x-ray crystal structure of streptococcus sanguinis dimanganese(ii)-2 nrdf Phyre2 1 d1afra_ 2 d1za0a1 3 c1r2fB_ 4 d1r2fa_ 5 c4bmtB_ 6 c5hyhA_ 7 d1uzra_ 8 d1smsa_ 9 c3hf1B_ 10 d1w68a_ 11 c2rccC_ 12 c4hr0A_ 13 c2p1iA_ 14 c3chtA_ 15 d1oquc_ 16 c3ee4A_ 17 c2o1zA_ 18 c1h0oA_ 19 d1jk0b_ 20 c4n83F_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115