1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	Q	D	T	S	A	T	C	P	L	T	S	T	V	Q	D	S	S	P	V	A	G	Q	L	G	R	P	I	G	F	R	G	L	A	G	G	C	P	V	S	P	L	G	Y	E	S	P	P	L	P	L	G	P	D	S	L	T	W	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Y	F	G	D	W	R	G	M	L	Q	G	P	W	A	G	S	M	Q	N	M	H	P	Q	L	G	A	A	V	E	D	H	S	T	F	F	R	E	R	W	P	R	L	L	R	S	L	Y	P	I	G	G	V	V	F	D	G	D	R	A	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	T	G	V	Q	V	R	D	Y	H	I	T	I	K	G	V	D	G	A	G	R	R	Y	H	A	L	N	P	D	V	F	Y	W	A	H	A	T	F	F	V	G	T	L	H	V	A	E	R	F	C	G	G	L	T	E	A	Q	R	R	Q
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	F	D	E	H	V	Q	W	Y	R	M	Y	G	M	S	M	R	P	V	P	A	T	W	E	E	F	Q	D	Y	W	D	H	M	C	R	N	V	L	E	N	N	F	A	A	R	A	V	L	D	L	T	E	L	P	K	P	P	F	A	Q
Secondary structure
SS confidence
Disorder																																																							?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	V	P	D	W	L	W	A	A	P	R	K	L	L	A	R	F	F	V	W	L	T	V	G	L	Y	D	P	P	V	R	E	L	M	G	Y	R	W	L	R	R	D	E	W	L	H	R	R	F	G	D	I	V	R	L	V	F	A	L	V
Secondary structure
SS confidence
Disorder		?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.
Sequence		P	F	R	F	R	K	H	P	R	A	R	A	G	W	D	R	A	T	G	R	I	P	A	D	A	P	L	V	Q	T	P	A	R	N	L	P	P	P	D	E	R	D	N	P	T	H	Y	C	P	K	V
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?					?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 25%) Alpha helix ( 62%) Beta strand ( 0%) TM helix ( 9%) (View membrane topology prediction)

Rank Aligned region

PDB 5o1m chain A Region: 55 - 301 Aligned: 235 Modelled: 247 Confidence: 99.3% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:rubber oxygenase; PDBTitle: structure of latex clearing protein lcp in the closed state Phyre2 PDB 2ru8 chain A Region: 183 - 212 Aligned: 30 Modelled: 30 Confidence: 39.1% Identity: 13% PDB header:replication Chain: A: PDB Molecule:primosomal protein 1; PDBTitle: dnat c-terminal domain Phyre2 PDB 4ou6 chain A Region: 183 - 212 Aligned: 30 Modelled: 30 Confidence: 27.9% Identity: 13% PDB header:replication/dna Chain: A: PDB Molecule:primosomal protein 1; PDBTitle: crystal structure of dnat84-153-dt10 ssdna complex form 1 Phyre2 PDB 5cuv chain B Region: 162 - 210 Aligned: 40 Modelled: 49 Confidence: 20.4% Identity: 20% PDB header:metal binding protein Chain: B: PDB Molecule:acidocalcisomal pyrophosphatase; PDBTitle: crystal structure of trypanosoma cruzi vacuolar soluble2 pyrophosphatases in apo form Phyre2 PDB 1g73 chain A Region: 161 - 184 Aligned: 24 Modelled: 24 Confidence: 16.2% Identity: 4% Fold: Spectrin repeat-like Superfamily: Smac/diablo Family: Smac/diablo Phyre2 PDB 4pla chain A Region: 126 - 184 Aligned: 59 Modelled: 59 Confidence: 14.8% Identity: 27% PDB header:transferase,hydrolase Chain: A: PDB Molecule:chimera protein of phosphatidylinositol 4-kinase type 2- PDBTitle: crystal structure of phosphatidyl inositol 4-kinase ii alpha in2 complex with atp Phyre2 PDB 1unh chain D Region: 145 - 192 Aligned: 48 Modelled: 48 Confidence: 14.0% Identity: 6% PDB header:cell cycle Chain: D: PDB Molecule:cyclin-dependent kinase 5 activator 1; PDBTitle: structural mechanism for the inhibition of cdk5-p25 by2 roscovitine, aloisine and indirubin. Phyre2 PDB 1unl chain D Region: 145 - 192 Aligned: 48 Modelled: 48 Confidence: 13.6% Identity: 6% Fold: Cyclin-like Superfamily: Cyclin-like Family: Cyclin Phyre2 PDB 4nk1 chain B Region: 172 - 213 Aligned: 38 Modelled: 42 Confidence: 13.0% Identity: 16% PDB header:oxygen binding Chain: B: PDB Molecule:hemoglobin-like protein; PDBTitle: crystal structure of phosphate-bound hell's gate globin iv Phyre2 PDB 2e8m chain A Region: 143 - 192 Aligned: 50 Modelled: 50 Confidence: 12.3% Identity: 22% PDB header:signaling protein Chain: A: PDB Molecule:epidermal growth factor receptor kinase PDBTitle: solution structure of the c-terminal sam-domain of2 epidermal growth receptor pathway substrate 8 Phyre2 PDB 4wiu chain A Region: 131 - 203 Aligned: 67 Modelled: 73 Confidence: 11.0% Identity: 18% PDB header:lyase,transferase Chain: A: PDB Molecule:phosphoenolpyruvate carboxykinase [gtp]; PDBTitle: crystal structure of pepck (rv0211) from mycobacterium tuberculosis in2 complex with oxalate and mn2+ Phyre2 PDB 1few chain A Region: 161 - 184 Aligned: 24 Modelled: 24 Confidence: 10.5% Identity: 4% Fold: Spectrin repeat-like Superfamily: Smac/diablo Family: Smac/diablo Phyre2 PDB 1u7k chain A Region: 149 - 188 Aligned: 40 Modelled: 40 Confidence: 9.9% Identity: 10% Fold: Retrovirus capsid protein, N-terminal core domain Superfamily: Retrovirus capsid protein, N-terminal core domain Family: Retrovirus capsid protein, N-terminal core domain Phyre2 PDB 6fvi chain A Region: 133 - 145 Aligned: 13 Modelled: 13 Confidence: 8.5% Identity: 46% PDB header:cell cycle Chain: A: PDB Molecule:centrosomal protein of 192 kda; PDBTitle: ash / papd-like domain of human cep192 (papd-like domain 7) Phyre2 PDB 2jsp chain A Region: 264 - 277 Aligned: 14 Modelled: 14 Confidence: 8.2% Identity: 14% PDB header:gene regulation Chain: A: PDB Molecule:transcriptional regulatory protein ros; PDBTitle: the prokaryotic cys2his2 zinc finger adopts a novel fold as2 revealed by the nmr structure of a. tumefaciens ros dna3 binding domain Phyre2 PDB 1nex chain C Region: 248 - 288 Aligned: 41 Modelled: 41 Confidence: 7.8% Identity: 12% PDB header:ligase, cell cycle Chain: C: PDB Molecule:centromere dna-binding protein complex cbf3 PDBTitle: crystal structure of scskp1-sccdc4-cpd peptide complex Phyre2 PDB 1v7b chain A domain 2 Region: 144 - 188 Aligned: 45 Modelled: 45 Confidence: 7.8% Identity: 9% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 1mk2 chain B Region: 343 - 351 Aligned: 9 Modelled: 9 Confidence: 7.7% Identity: 44% PDB header:transcription Chain: B: PDB Molecule:madh-interacting protein; PDBTitle: smad3 sbd complex Phyre2 PDB 4do7 chain B Region: 159 - 195 Aligned: 35 Modelled: 37 Confidence: 7.6% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:amidohydrolase 2; PDBTitle: crystal structure of an amidohydrolase (cog3618) from burkholderia2 multivorans (target efi-500235) with bound zn, space group c2 Phyre2 PDB 6aly chain A Region: 173 - 219 Aligned: 45 Modelled: 47 Confidence: 7.4% Identity: 13% PDB header:transcription Chain: A: PDB Molecule:mediator of rna polymerase ii transcription subunit 15; PDBTitle: solution structure of yeast med15 abd2 residues 277-368 Phyre2 1 c5o1mA_ 2 c2ru8A_ 3 c4ou6A_ 4 c5cuvB_ 5 d1g73a_ 6 c4plaA_ 7 c1unhD_ 8 d1unld_ 9 c4nk1B_ 10 c2e8mA_ 11 c4wiuA_ 12 d1fewa_ 13 d1u7ka_ 14 c6fviA_ 15 c2jspA_ 16 c1nexC_ 17 d1v7ba2 18 c1mk2B_ 19 c4do7B_ 20 c6alyA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46